A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity.
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| Title: | A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity. |
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| Authors: | Demenescu, Liliana, Colic, Lejla, Li, Meng, Safron, Adam, Biswal, B., Metzger, Coraline, Li, Shijia, Walter, Martin |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Mar2017, Vol. 267 Issue 2, p95-105. 11p. |
| Subjects: | Diagnosis of mental depression, Brain metabolism, Cingulate cortex, Insular cortex, Functional magnetic resonance imaging, Glutamic acid |
| Abstract: | Abnormal anterior insula (AI) response and functional connectivity (FC) is associated with depression. In addition to clinical features, such as severity, AI FC and its metabolism further predicted therapeutic response. Abnormal FC between anterior cingulate and AI covaried with reduced glutamate level within cingulate cortex. Recently, deficient glial glutamate conversion was found in AI in major depression disorder (MDD). We therefore postulate a local glutamatergic mechanism in insula cortex of depressive patients, which is correlated with symptoms severity and itself influences AI's network connectivity in MDD. Twenty-five MDD patients and 25 healthy controls (HC) matched on age and sex underwent resting state functional magnetic resonance imaging and magnetic resonance spectroscopy scans. To determine the role of local glutamate-glutamine complex (Glx) ratio on whole brain AI FC, we conducted regression analysis with Glx relative to creatine (Cr) ratio as factor of interest and age, sex, and voxel tissue composition as nuisance factors. We found that in MDD, but not in HC, AI Glx/Cr ratio correlated positively with AI FC to right supramarginal gyrus and negatively with AI FC toward left occipital cortex ( p < 0.05 family wise error). AI Glx/Cr level was negatively correlated with HAMD score ( p < 0.05) in MDD patients. We showed that the local AI ratio of glutamatergic-creatine metabolism is an underlying candidate subserving functional network disintegration of insula toward low level and supramodal integration areas, in MDD. While causality cannot directly be inferred from such correlation, our finding helps to define a multilevel network of response-predicting regions based on local metabolism and connectivity strength. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 121412717 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Demenescu%2C+Liliana%22">Demenescu, Liliana</searchLink><br /><searchLink fieldCode="AR" term="%22Colic%2C+Lejla%22">Colic, Lejla</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Meng%22">Li, Meng</searchLink><br /><searchLink fieldCode="AR" term="%22Safron%2C+Adam%22">Safron, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Biswal%2C+B%2E%22">Biswal, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Metzger%2C+Coraline%22">Metzger, Coraline</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Shijia%22">Li, Shijia</searchLink><br /><searchLink fieldCode="AR" term="%22Walter%2C+Martin%22">Walter, Martin</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2017, Vol. 267 Issue 2, p95-105. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diagnosis+of+mental+depression%22">Diagnosis of mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+metabolism%22">Brain metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Cingulate+cortex%22">Cingulate cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Insular+cortex%22">Insular cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Glutamic+acid%22">Glutamic acid</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abnormal anterior insula (AI) response and functional connectivity (FC) is associated with depression. In addition to clinical features, such as severity, AI FC and its metabolism further predicted therapeutic response. Abnormal FC between anterior cingulate and AI covaried with reduced glutamate level within cingulate cortex. Recently, deficient glial glutamate conversion was found in AI in major depression disorder (MDD). We therefore postulate a local glutamatergic mechanism in insula cortex of depressive patients, which is correlated with symptoms severity and itself influences AI's network connectivity in MDD. Twenty-five MDD patients and 25 healthy controls (HC) matched on age and sex underwent resting state functional magnetic resonance imaging and magnetic resonance spectroscopy scans. To determine the role of local glutamate-glutamine complex (Glx) ratio on whole brain AI FC, we conducted regression analysis with Glx relative to creatine (Cr) ratio as factor of interest and age, sex, and voxel tissue composition as nuisance factors. We found that in MDD, but not in HC, AI Glx/Cr ratio correlated positively with AI FC to right supramarginal gyrus and negatively with AI FC toward left occipital cortex ( p < 0.05 family wise error). AI Glx/Cr level was negatively correlated with HAMD score ( p < 0.05) in MDD patients. We showed that the local AI ratio of glutamatergic-creatine metabolism is an underlying candidate subserving functional network disintegration of insula toward low level and supramodal integration areas, in MDD. While causality cannot directly be inferred from such correlation, our finding helps to define a multilevel network of response-predicting regions based on local metabolism and connectivity strength. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-016-0726-1 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 95 Subjects: – SubjectFull: Diagnosis of mental depression Type: general – SubjectFull: Brain metabolism Type: general – SubjectFull: Cingulate cortex Type: general – SubjectFull: Insular cortex Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Glutamic acid Type: general Titles: – TitleFull: A spectroscopic approach toward depression diagnosis: local metabolism meets functional connectivity. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Demenescu, Liliana – PersonEntity: Name: NameFull: Colic, Lejla – PersonEntity: Name: NameFull: Li, Meng – PersonEntity: Name: NameFull: Safron, Adam – PersonEntity: Name: NameFull: Biswal, B. – PersonEntity: Name: NameFull: Metzger, Coraline – PersonEntity: Name: NameFull: Li, Shijia – PersonEntity: Name: NameFull: Walter, Martin IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 267 – Type: issue Value: 2 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
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