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Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease.

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Title: Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease.
Authors: Williams, N. R., Bentzley, B. S., Sahlem, G. L., Pannu, J., Korte, J. E., Revuelta, G., Short, E. B., George, M. S.
Source: Acta Neurologica Scandinavica. Apr2017, Vol. 135 Issue 4, p407-411. 5p.
Subjects: Parkinson's disease treatment, Electroconvulsive therapy, Therapeutics, Mental depression, Symptoms, Treatment effectiveness
Abstract: Objectives Electroconvulsive therapy ( ECT) has demonstrated efficacy in treating core symptoms of Parkinson's disease ( PD); however, widespread use of ECT in PD has been limited due to concern over cognitive burden. We investigated the use of a newer ECT technology known to have fewer cognitive side effects (right unilateral [ RUL] ultra-brief pulse [ UBP]) for the treatment of medically refractory psychiatric dysfunction in PD. Materials and methods This open-label pilot study included 6 patients who were assessed in the motoric, cognitive, and neuropsychiatric domains prior to and after RUL UBP ECT. Primary endpoints were changes in total score on the HAM-D-17 and GDS-30 rating scales. Results Patients were found to improve in motoric and psychiatric domains following RUL UBP ECT without cognitive side effects, both immediately following ECT and at 1-month follow-up. Conclusions This study demonstrates that RUL UBP ECT is safe, feasible, and potentially efficacious in treating multiple domains of PD, including motor and mood, without clear cognitive side effects. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Unilateral ultra-brief pulse electroconvulsive therapy for depression in Parkinson's disease.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Apr2017, Vol. 135 Issue 4, p407-411. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease+treatment%22">Parkinson's disease treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Electroconvulsive+therapy%22">Electroconvulsive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink>
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  Label: Abstract
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  Data: Objectives Electroconvulsive therapy ( ECT) has demonstrated efficacy in treating core symptoms of Parkinson's disease ( PD); however, widespread use of ECT in PD has been limited due to concern over cognitive burden. We investigated the use of a newer ECT technology known to have fewer cognitive side effects (right unilateral [ RUL] ultra-brief pulse [ UBP]) for the treatment of medically refractory psychiatric dysfunction in PD. Materials and methods This open-label pilot study included 6 patients who were assessed in the motoric, cognitive, and neuropsychiatric domains prior to and after RUL UBP ECT. Primary endpoints were changes in total score on the HAM-D-17 and GDS-30 rating scales. Results Patients were found to improve in motoric and psychiatric domains following RUL UBP ECT without cognitive side effects, both immediately following ECT and at 1-month follow-up. Conclusions This study demonstrates that RUL UBP ECT is safe, feasible, and potentially efficacious in treating multiple domains of PD, including motor and mood, without clear cognitive side effects. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Apr2017
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