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Beliefs about the causes of depression and recovery and their impact on adherence, dosage, and successful tapering of antidepressants.

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Title: Beliefs about the causes of depression and recovery and their impact on adherence, dosage, and successful tapering of antidepressants.
Authors: Klein, Nicola S., Rijsbergen, Gerard D., ten Doesschate, Mascha C., Hollon, Steven D., Burger, Huibert, Bockting, Claudi L. H.
Source: Depression & Anxiety (1091-4269). Mar2017, Vol. 34 Issue 3, p227-235. 9p. 5 Charts.
Subjects: Antidepressants, Mental depression, Therapeutics, Patient compliance, Drug dosage, Drug efficacy, Disease relapse prevention, Cognitive therapy, Comparative studies, Drugs, Dose-effect relationship in pharmacology, Health attitudes, Research methodology, Medical cooperation, Research, Evaluation research, Randomized controlled trials, Disease remission
Abstract: Background: Continuation of antidepressant medication (ADM) after remission is widely used to prevent depressive relapse/recurrence. Little is known about predictors of ADM use in terms of adherence, dosage, and successful tapering. The current study aimed to explore beliefs about the causes of depression and recovery (i.e., causal beliefs) and to examine whether they predict ADM use.Methods: The data were drawn from a controlled trial and an extension of this trial with additional experience sampling. In total, 289 remitted patients with recurrent depression (ADM ≥ 6 months) were randomly assigned to Preventive Cognitive Therapy (PCT) with ADM tapering, PCT with maintenance ADM, or maintenance ADM alone. Adherence, ADM dosage, and causal beliefs regarding the first and last depressive episodes were explored via questionnaires.Results: Most patients mentioned stressful life events as cause of depression, although more patients tended to endorse external causes for the first episode and internal causes for the last episode. ADM was most often mentioned as helpful during recovery from both episodes. Over half of all patients were adherent and under half of the patients in the tapering condition were able to complete the taper. Causal beliefs did not predict ADM use.Conclusions: The results suggest that causal beliefs play little role in the use of maintenance ADM. More information is needed on factors contributing to successful tapering. The results must be interpreted with caution as this is not a naturalistic study and the results might be biased toward a more favorable view regarding ADM. [ABSTRACT FROM AUTHOR]
Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Beliefs about the causes of depression and recovery and their impact on adherence, dosage, and successful tapering of antidepressants.
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  Data: <searchLink fieldCode="AR" term="%22Klein%2C+Nicola+S%2E%22">Klein, Nicola S.</searchLink><br /><searchLink fieldCode="AR" term="%22Rijsbergen%2C+Gerard+D%2E%22">Rijsbergen, Gerard D.</searchLink><br /><searchLink fieldCode="AR" term="%22ten+Doesschate%2C+Mascha+C%2E%22">ten Doesschate, Mascha C.</searchLink><br /><searchLink fieldCode="AR" term="%22Hollon%2C+Steven+D%2E%22">Hollon, Steven D.</searchLink><br /><searchLink fieldCode="AR" term="%22Burger%2C+Huibert%22">Burger, Huibert</searchLink><br /><searchLink fieldCode="AR" term="%22Bockting%2C+Claudi+L%2E+H%2E%22">Bockting, Claudi L. H.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. Mar2017, Vol. 34 Issue 3, p227-235. 9p. 5 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+dosage%22">Drug dosage</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+relapse+prevention%22">Disease relapse prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+therapy%22">Cognitive therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Dose-effect+relationship+in+pharmacology%22">Dose-effect relationship in pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Health+attitudes%22">Health attitudes</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+remission%22">Disease remission</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: <bold>Background: </bold>Continuation of antidepressant medication (ADM) after remission is widely used to prevent depressive relapse/recurrence. Little is known about predictors of ADM use in terms of adherence, dosage, and successful tapering. The current study aimed to explore beliefs about the causes of depression and recovery (i.e., causal beliefs) and to examine whether they predict ADM use.<bold>Methods: </bold>The data were drawn from a controlled trial and an extension of this trial with additional experience sampling. In total, 289 remitted patients with recurrent depression (ADM ≥ 6 months) were randomly assigned to Preventive Cognitive Therapy (PCT) with ADM tapering, PCT with maintenance ADM, or maintenance ADM alone. Adherence, ADM dosage, and causal beliefs regarding the first and last depressive episodes were explored via questionnaires.<bold>Results: </bold>Most patients mentioned stressful life events as cause of depression, although more patients tended to endorse external causes for the first episode and internal causes for the last episode. ADM was most often mentioned as helpful during recovery from both episodes. Over half of all patients were adherent and under half of the patients in the tapering condition were able to complete the taper. Causal beliefs did not predict ADM use.<bold>Conclusions: </bold>The results suggest that causal beliefs play little role in the use of maintenance ADM. More information is needed on factors contributing to successful tapering. The results must be interpreted with caution as this is not a naturalistic study and the results might be biased toward a more favorable view regarding ADM. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=121609143
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      – Type: doi
        Value: 10.1002/da.22598
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 227
    Subjects:
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Drug dosage
        Type: general
      – SubjectFull: Drug efficacy
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      – SubjectFull: Disease relapse prevention
        Type: general
      – SubjectFull: Cognitive therapy
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      – SubjectFull: Comparative studies
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      – SubjectFull: Drugs
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      – SubjectFull: Dose-effect relationship in pharmacology
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      – SubjectFull: Health attitudes
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      – SubjectFull: Research methodology
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      – SubjectFull: Medical cooperation
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      – SubjectFull: Randomized controlled trials
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      – SubjectFull: Disease remission
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      – TitleFull: Beliefs about the causes of depression and recovery and their impact on adherence, dosage, and successful tapering of antidepressants.
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              Text: Mar2017
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              Y: 2017
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