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Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort.

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Title: Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort.
Authors: Black, C. N., Bot, M., Scheffer, P. G., Penninx, B. W. J. H.
Source: Psychological Medicine. Apr2017, Vol. 47 Issue 5, p936-948. 13p.
Subjects: Antidepressants, Antioxidants, Anxiety, Blood plasma, Mental depression, Serotonin uptake inhibitors, Causal models, Oxidative stress, Anxiety disorders, Lifestyles
Geographic Terms: Netherlands
Abstract: BackgroundOxidative stress has been implicated in the pathophysiology of major depressive disorder (MDD) and anxiety disorders and may be influenced by antidepressant use. This study investigated the association of oxidative stress, measured by plasma levels of F2-isoprostanes and 8-hydroxy-2′-deoxyguanosine (8-OHdG) reflecting oxidative lipid and DNA damage respectively, with MDD, anxiety disorders and antidepressant use in a large cohort.MethodData was derived from the Netherlands Study of Depression and Anxiety including patients with current (N = 1619) or remitted (N = 610) MDD and/or anxiety disorder(s) (of which N = 704 antidepressant users) and 612 controls. Diagnoses were established with the Composite International Diagnostic Interview. Plasma 8-OHdG and F2-isoprostanes were measured using LC-MS/MS. ANCOVA was performed adjusted for sampling, sociodemographic, health and lifestyle variables.ResultsF2-isoprostanes did not differ between controls and patients, or by antidepressant use. Patients with current disorders had lower 8-OHdG (mean 42.1 pmol/l, 95% CI 40.4–43.8) compared to controls (45.0 pmol/l, 95% CI 42.9–47.2; p < 0.001) after adjustment for sampling, sociodemographics and lifestyle, but these differences disappeared after further adjustment for antidepressant use (p = 0.562). Antidepressant users had lower 8-OHdG levels (38.2 pmol/l, 95% CI 36.5–39.9) compared to controls (44.9 pmol/l, 95% CI 43.2–46.6; Cohen's d = 0.21, p < 0.001). Results for 8-OHdG were comparable across disorders (MDD and/or anxiety disorders), and all antidepressant types (SSRIs, TCAs, other antidepressants).ConclusionContrary to previous findings this large-scale study found no increased oxidative stress in MDD and anxiety disorders. Antidepressant use was associated with lower oxidative DNA damage, suggesting antidepressants may have antioxidant effects. [ABSTRACT FROM PUBLISHER]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Black%2C+C%2E+N%2E%22&quot;&gt;Black, C. N.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bot%2C+M%2E%22&quot;&gt;Bot, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Scheffer%2C+P%2E+G%2E%22&quot;&gt;Scheffer, P. G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Penninx%2C+B%2E+W%2E+J%2E+H%2E%22&quot;&gt;Penninx, B. W. J. H.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychological+Medicine%22&quot;&gt;Psychological Medicine&lt;/searchLink&gt;. Apr2017, Vol. 47 Issue 5, p936-948. 13p.
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  Data: BackgroundOxidative stress has been implicated in the pathophysiology of major depressive disorder (MDD) and anxiety disorders and may be influenced by antidepressant use. This study investigated the association of oxidative stress, measured by plasma levels of F2-isoprostanes and 8-hydroxy-2′-deoxyguanosine (8-OHdG) reflecting oxidative lipid and DNA damage respectively, with MDD, anxiety disorders and antidepressant use in a large cohort.MethodData was derived from the Netherlands Study of Depression and Anxiety including patients with current (N = 1619) or remitted (N = 610) MDD and/or anxiety disorder(s) (of which N = 704 antidepressant users) and 612 controls. Diagnoses were established with the Composite International Diagnostic Interview. Plasma 8-OHdG and F2-isoprostanes were measured using LC-MS/MS. ANCOVA was performed adjusted for sampling, sociodemographic, health and lifestyle variables.ResultsF2-isoprostanes did not differ between controls and patients, or by antidepressant use. Patients with current disorders had lower 8-OHdG (mean 42.1 pmol/l, 95% CI 40.4–43.8) compared to controls (45.0 pmol/l, 95% CI 42.9–47.2; p &lt; 0.001) after adjustment for sampling, sociodemographics and lifestyle, but these differences disappeared after further adjustment for antidepressant use (p = 0.562). Antidepressant users had lower 8-OHdG levels (38.2 pmol/l, 95% CI 36.5–39.9) compared to controls (44.9 pmol/l, 95% CI 43.2–46.6; Cohen&#39;s d = 0.21, p &lt; 0.001). Results for 8-OHdG were comparable across disorders (MDD and/or anxiety disorders), and all antidepressant types (SSRIs, TCAs, other antidepressants).ConclusionContrary to previous findings this large-scale study found no increased oxidative stress in MDD and anxiety disorders. Antidepressant use was associated with lower oxidative DNA damage, suggesting antidepressants may have antioxidant effects. [ABSTRACT FROM PUBLISHER]
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  Data: &lt;i&gt;Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=121624516
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1017/S0033291716002828
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        Text: English
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        Type: general
      – SubjectFull: Antioxidants
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      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Blood plasma
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      – SubjectFull: Mental depression
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      – SubjectFull: Serotonin uptake inhibitors
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      – SubjectFull: Causal models
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      – SubjectFull: Oxidative stress
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      – SubjectFull: Anxiety disorders
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      – SubjectFull: Lifestyles
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      – SubjectFull: Netherlands
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      – TitleFull: Oxidative stress in major depressive and anxiety disorders, and the association with antidepressant use; results from a large adult cohort.
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            NameFull: Black, C. N.
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            NameFull: Scheffer, P. G.
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              Text: Apr2017
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