Blood pressure, nimodipine, and outcome of ischemic stroke.
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| Title: | Blood pressure, nimodipine, and outcome of ischemic stroke. |
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| Authors: | Fogelholm, R., Palomäki, H., Erilä, T., Rissanen, A., Kaste, M. |
| Source: | Acta Neurologica Scandinavica. Mar2004, Vol. 109 Issue 3, p200-204. 5p. |
| Subjects: | Blood pressure, Nimodipine, Tomography, Cerebral infarction, Disease risk factors, Body fluid pressure |
| Abstract: | Fogelholm R, Palomäki H, Erilä T, Rissanen A, Kaste M. Blood pressure, nimodipine, and outcome of ischemic stroke. Acta Neurol Scand 2003 DOI: 10.1046/j.1600-0404.2003.00202.x © Blackwell Munksgaard 2003. The reduction of blood pressure (BP) caused by nimodipine has been proposed as an explanation for the poor results in ischemic stroke trials. We evaluated further the relationships between BP, nimodipine, and outcome of ischemic stroke, and also searched for other possible explaining mechanisms. All 350 participants of an earlier placebo controlled trial on oral nimodipine were included in this study. Among other variables, the admission BP, and the change of BP during the first day were noted. The 3 week and 3 month functional outcome was assessed with a modified Rankin grading. The severity of stroke was the utmost important predictor of outcome. Visible cerebral infarction on computed tomography (CT) was associated with severe stroke and an early commencement (within 24 h of stroke onset) of nimodipine treatment. In the nimodipine arm, high initial systolic and diastolic BP measured ≤24 h of stroke onset were independent predictors of good functional outcome (Rankin grades 1 and 2), whereas BP change was not. The survivors in the nimodipine arm with mild to moderately severe stroke had higher initial BP than the deceased ones, in severe strokes the situation was the opposite. Stroke severity, visible cerebral infarcts on CT, and early commencement of nimodipine treatment were associated. Overall, high initial systolic and diastolic BP predicted a good functional outcome in patients on nimodipine. In severe strokes, the combination of nimodipine and high initial BP was associated with increased risk of death. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 12164469 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Blood pressure, nimodipine, and outcome of ischemic stroke. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fogelholm%2C+R%2E%22">Fogelholm, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Palomäki%2C+H%2E%22">Palomäki, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Erilä%2C+T%2E%22">Erilä, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Rissanen%2C+A%2E%22">Rissanen, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaste%2C+M%2E%22">Kaste, M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Mar2004, Vol. 109 Issue 3, p200-204. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Nimodipine%22">Nimodipine</searchLink><br /><searchLink fieldCode="DE" term="%22Tomography%22">Tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+infarction%22">Cerebral infarction</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Body+fluid+pressure%22">Body fluid pressure</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Fogelholm R, Palomäki H, Erilä T, Rissanen A, Kaste M. Blood pressure, nimodipine, and outcome of ischemic stroke. Acta Neurol Scand 2003 DOI: 10.1046/j.1600-0404.2003.00202.x © Blackwell Munksgaard 2003. The reduction of blood pressure (BP) caused by nimodipine has been proposed as an explanation for the poor results in ischemic stroke trials. We evaluated further the relationships between BP, nimodipine, and outcome of ischemic stroke, and also searched for other possible explaining mechanisms. All 350 participants of an earlier placebo controlled trial on oral nimodipine were included in this study. Among other variables, the admission BP, and the change of BP during the first day were noted. The 3 week and 3 month functional outcome was assessed with a modified Rankin grading. The severity of stroke was the utmost important predictor of outcome. Visible cerebral infarction on computed tomography (CT) was associated with severe stroke and an early commencement (within 24 h of stroke onset) of nimodipine treatment. In the nimodipine arm, high initial systolic and diastolic BP measured ≤24 h of stroke onset were independent predictors of good functional outcome (Rankin grades 1 and 2), whereas BP change was not. The survivors in the nimodipine arm with mild to moderately severe stroke had higher initial BP than the deceased ones, in severe strokes the situation was the opposite. Stroke severity, visible cerebral infarcts on CT, and early commencement of nimodipine treatment were associated. Overall, high initial systolic and diastolic BP predicted a good functional outcome in patients on nimodipine. In severe strokes, the combination of nimodipine and high initial BP was associated with increased risk of death. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1034/j.1600-0404.2003.00202.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 200 Subjects: – SubjectFull: Blood pressure Type: general – SubjectFull: Nimodipine Type: general – SubjectFull: Tomography Type: general – SubjectFull: Cerebral infarction Type: general – SubjectFull: Disease risk factors Type: general – SubjectFull: Body fluid pressure Type: general Titles: – TitleFull: Blood pressure, nimodipine, and outcome of ischemic stroke. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fogelholm, R. – PersonEntity: Name: NameFull: Palomäki, H. – PersonEntity: Name: NameFull: Erilä, T. – PersonEntity: Name: NameFull: Rissanen, A. – PersonEntity: Name: NameFull: Kaste, M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 109 – Type: issue Value: 3 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
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