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Amyloid burden and incident depressive symptoms in cognitively normal older adults.

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Title: Amyloid burden and incident depressive symptoms in cognitively normal older adults.
Authors: Harrington, Karra D., Gould, Emma, Lim, Yen Ying, Ames, David, Pietrzak, Robert H., Rembach, Alan, Rainey‐Smith, Stephanie, Martins, Ralph N., Salvado, Olivier, Villemagne, Victor L., Rowe, Christopher C., Masters, Colin L., Maruff, Paul, Rainey-Smith, Stephanie (AUTHOR), AIBL Research Group (CORPORATE AUTHOR)
Source: International Journal of Geriatric Psychiatry. Apr2017, Vol. 32 Issue 4, p455-463. 9p.
Subjects: Amyloid, Depression in old age, Mental depression, Alzheimer's disease, Senile dementia
Abstract: Objective: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period.Methods: Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale - Short Form at 18-month intervals over 54 months.Results: Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3-16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54-month assessment.Conclusions: Results of this study suggest that elevated Aβ levels are associated with a 4.5-fold increased likelihood of developing clinically significant depressive symptoms on follow-up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Amyloid burden and incident depressive symptoms in cognitively normal older adults.
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  Data: <searchLink fieldCode="AR" term="%22Harrington%2C+Karra+D%2E%22">Harrington, Karra D.</searchLink><br /><searchLink fieldCode="AR" term="%22Gould%2C+Emma%22">Gould, Emma</searchLink><br /><searchLink fieldCode="AR" term="%22Lim%2C+Yen+Ying%22">Lim, Yen Ying</searchLink><br /><searchLink fieldCode="AR" term="%22Ames%2C+David%22">Ames, David</searchLink><br /><searchLink fieldCode="AR" term="%22Pietrzak%2C+Robert+H%2E%22">Pietrzak, Robert H.</searchLink><br /><searchLink fieldCode="AR" term="%22Rembach%2C+Alan%22">Rembach, Alan</searchLink><br /><searchLink fieldCode="AR" term="%22Rainey‐Smith%2C+Stephanie%22">Rainey‐Smith, Stephanie</searchLink><br /><searchLink fieldCode="AR" term="%22Martins%2C+Ralph+N%2E%22">Martins, Ralph N.</searchLink><br /><searchLink fieldCode="AR" term="%22Salvado%2C+Olivier%22">Salvado, Olivier</searchLink><br /><searchLink fieldCode="AR" term="%22Villemagne%2C+Victor+L%2E%22">Villemagne, Victor L.</searchLink><br /><searchLink fieldCode="AR" term="%22Rowe%2C+Christopher+C%2E%22">Rowe, Christopher C.</searchLink><br /><searchLink fieldCode="AR" term="%22Masters%2C+Colin+L%2E%22">Masters, Colin L.</searchLink><br /><searchLink fieldCode="AR" term="%22Maruff%2C+Paul%22">Maruff, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Rainey-Smith%2C+Stephanie%22">Rainey-Smith, Stephanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22AIBL+Research+Group%22">AIBL Research Group</searchLink> (CORPORATE AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. Apr2017, Vol. 32 Issue 4, p455-463. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Amyloid%22">Amyloid</searchLink><br /><searchLink fieldCode="DE" term="%22Depression+in+old+age%22">Depression in old age</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Senile+dementia%22">Senile dementia</searchLink>
– Name: Abstract
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  Data: <bold>Objective: </bold>Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer's disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We sought to determine the relation between elevated cerebral Aβ and the presence of depression across a 54-month prospective observation period.<bold>Methods: </bold>Cognitively normal older adults from the Australian Imaging Biomarkers and Lifestyle study who were not depressed and had undergone a positron emission tomography scan to classify them as either high Aβ (n = 81) or low Aβ (n = 278) participated. Depressive symptoms were assessed using the Geriatric Depression Scale - Short Form at 18-month intervals over 54 months.<bold>Results: </bold>Whilst there was no difference in probable depression between groups at baseline, incidence was 4.5 (95% confidence interval [CI] 1.3-16.4) times greater within the high Aβ group (9%) than the low Aβ group (2%) by the 54-month assessment.<bold>Conclusions: </bold>Results of this study suggest that elevated Aβ levels are associated with a 4.5-fold increased likelihood of developing clinically significant depressive symptoms on follow-up in preclinical Alzheimer's disease. This underscores the importance of assessing, monitoring and treating depressive symptoms in older adults with elevated Aβ. Copyright © 2016 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/gps.4489
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      – Code: eng
        Text: English
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        PageCount: 9
        StartPage: 455
    Subjects:
      – SubjectFull: Amyloid
        Type: general
      – SubjectFull: Depression in old age
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Alzheimer's disease
        Type: general
      – SubjectFull: Senile dementia
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    Titles:
      – TitleFull: Amyloid burden and incident depressive symptoms in cognitively normal older adults.
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              Text: Apr2017
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