View in EDS HTML Full Text PDF Full Text

Inflammation boosts bacteriophage transfer between Salmonella spp.

Saved in:
Bibliographic Details
Title: Inflammation boosts bacteriophage transfer between Salmonella spp.
Authors: Diard, Médéric, Bakkeren, Erik, Cornuault, Jeffrey K., Moor, Kathrin, Hausmann, Annika, Sellin, Mikael E., Loverdo, Claude, Aertsen, Abram, Ackermann, Martin, De Paepe, Marianne, Slack, Emma, Hardt, Wolf-Dietrich
Source: Science (pre-March 2025). 3/17/2017, Vol. 355 Issue 6330, p1211-1215. 5p. 4 Diagrams.
Subjects: Bacteriophages, Microbial virulence, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa
Abstract: Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. A murine Salmonella Typhimurium (S.Tm) diarrhea model was used to study the transfer of SopEΦ, a prophage from S.Tm SL1344, to S.Tm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEΦ transfer was reduced by up to 105-fold. This was because inflammation (e.g., reactive oxygen species, reactive nitrogen species, hypochlorite) triggers the bacterial SOS response, boosts expression of the phage antirepressor Tum, and thereby promotes free phage production and subsequent transfer. Mucosal vaccination prevented a dense intestinal S.Tm population from inducing inflammation and consequently abolished SopEΦ transfer. Vaccination may be a general strategy for blocking pathogen evolution that requires disease-driven transfer of temperate bacteriophages. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 122015020
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Inflammation boosts bacteriophage transfer between Salmonella spp.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Diard%2C+Médéric%22">Diard, Médéric</searchLink><br /><searchLink fieldCode="AR" term="%22Bakkeren%2C+Erik%22">Bakkeren, Erik</searchLink><br /><searchLink fieldCode="AR" term="%22Cornuault%2C+Jeffrey+K%2E%22">Cornuault, Jeffrey K.</searchLink><br /><searchLink fieldCode="AR" term="%22Moor%2C+Kathrin%22">Moor, Kathrin</searchLink><br /><searchLink fieldCode="AR" term="%22Hausmann%2C+Annika%22">Hausmann, Annika</searchLink><br /><searchLink fieldCode="AR" term="%22Sellin%2C+Mikael+E%2E%22">Sellin, Mikael E.</searchLink><br /><searchLink fieldCode="AR" term="%22Loverdo%2C+Claude%22">Loverdo, Claude</searchLink><br /><searchLink fieldCode="AR" term="%22Aertsen%2C+Abram%22">Aertsen, Abram</searchLink><br /><searchLink fieldCode="AR" term="%22Ackermann%2C+Martin%22">Ackermann, Martin</searchLink><br /><searchLink fieldCode="AR" term="%22De+Paepe%2C+Marianne%22">De Paepe, Marianne</searchLink><br /><searchLink fieldCode="AR" term="%22Slack%2C+Emma%22">Slack, Emma</searchLink><br /><searchLink fieldCode="AR" term="%22Hardt%2C+Wolf-Dietrich%22">Hardt, Wolf-Dietrich</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/17/2017, Vol. 355 Issue 6330, p1211-1215. 5p. 4 Diagrams.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Bacteriophages%22">Bacteriophages</searchLink><br /><searchLink fieldCode="DE" term="%22Microbial+virulence%22">Microbial virulence</searchLink><br /><searchLink fieldCode="DE" term="%22Staphylococcus+aureus%22">Staphylococcus aureus</searchLink><br /><searchLink fieldCode="DE" term="%22Escherichia+coli%22">Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22Pseudomonas+aeruginosa%22">Pseudomonas aeruginosa</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. A murine Salmonella Typhimurium (S.Tm) diarrhea model was used to study the transfer of SopEΦ, a prophage from S.Tm SL1344, to S.Tm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEΦ transfer was reduced by up to 105-fold. This was because inflammation (e.g., reactive oxygen species, reactive nitrogen species, hypochlorite) triggers the bacterial SOS response, boosts expression of the phage antirepressor Tum, and thereby promotes free phage production and subsequent transfer. Mucosal vaccination prevented a dense intestinal S.Tm population from inducing inflammation and consequently abolished SopEΦ transfer. Vaccination may be a general strategy for blocking pathogen evolution that requires disease-driven transfer of temperate bacteriophages. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=122015020
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.aaf8451
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 1211
    Subjects:
      – SubjectFull: Bacteriophages
        Type: general
      – SubjectFull: Microbial virulence
        Type: general
      – SubjectFull: Staphylococcus aureus
        Type: general
      – SubjectFull: Escherichia coli
        Type: general
      – SubjectFull: Pseudomonas aeruginosa
        Type: general
    Titles:
      – TitleFull: Inflammation boosts bacteriophage transfer between Salmonella spp.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Diard, Médéric
      – PersonEntity:
          Name:
            NameFull: Bakkeren, Erik
      – PersonEntity:
          Name:
            NameFull: Cornuault, Jeffrey K.
      – PersonEntity:
          Name:
            NameFull: Moor, Kathrin
      – PersonEntity:
          Name:
            NameFull: Hausmann, Annika
      – PersonEntity:
          Name:
            NameFull: Sellin, Mikael E.
      – PersonEntity:
          Name:
            NameFull: Loverdo, Claude
      – PersonEntity:
          Name:
            NameFull: Aertsen, Abram
      – PersonEntity:
          Name:
            NameFull: Ackermann, Martin
      – PersonEntity:
          Name:
            NameFull: De Paepe, Marianne
      – PersonEntity:
          Name:
            NameFull: Slack, Emma
      – PersonEntity:
          Name:
            NameFull: Hardt, Wolf-Dietrich
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 17
              M: 03
              Text: 3/17/2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 355
            – Type: issue
              Value: 6330
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1