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Depression and the risk of vascular dementia: a population-based retrospective cohort study.

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Title: Depression and the risk of vascular dementia: a population-based retrospective cohort study.
Authors: Lin, Wei‐Chen, Hu, Li‐Yu, Tsai, Shih‐Jen, Yang, Albert C., Shen, Cheng‐Che, Lin, Wei-Chen (AUTHOR), Hu, Li-Yu (AUTHOR), Tsai, Shih-Jen (AUTHOR), Shen, Cheng-Che (AUTHOR)
Source: International Journal of Geriatric Psychiatry. May2017, Vol. 32 Issue 5, p556-563. 8p.
Subjects: Mental depression risk factors, Vascular dementia, Coronary disease, Cerebrovascular disease, Epidemiology, Regression analysis, Disease risk factors
Abstract: Objective: To examine the association between the risks of depression and vascular dementia (VaD) based on Taiwan's National Health Insurance Research Database.Methods: This retrospective longitudinal matched-cohort study used National Health Insurance Research Database data from 49,955 participants (9,991 with new onset depression, 39,964 controls). A Cox regression analysis was performed on the whole sample and the subgroup of patients with depression. We further excluded patients who developed VaD within 3 or 5 years after enrollment to evaluate depression as an independent risk factor for or a prodrome of VaD.Results: During the 10-year follow-up period, the incidence rate ratio of VaD between patients with depression and controls was 4.24 [95% confidence interval (CI) 2.90-6.21, P < 0.001]. After adjustment for covariates, the hazard ratio (HR) of VaD in patients with depression was 3.10 (95% CI 2.13-4.52, P < 0.001). In the whole sample, risk factors for VaD besides depression were aged ≥60 years (HR = 20.08), hypertension (HR = 1.70), diabetes (HR = 1.61), coronary artery disease (HR = 2.26), head injury (HR = 2.20), and cerebrovascular disease (HR = 3.02). In patients with depression, aged ≥60 years (HR = 32.16), coronary artery disease (HR = 2.82), head injury (HR = 2.06), and cerebrovascular disease (HR = 2.37) remained risk factors for VaD. After excluding those who developed VaD within 3 or 5 years, HRs remained high (3.28, 95% CI 2.03-5.31, P < 0.001; 2.12, 95% CI 1.05-4.25, P = 0.035, respectively).Conclusions: Our findings suggest that depression is an independent risk factor for subsequent VaD. Older age, cerebrovascular disease, head injury, and coronary artery disease might increase the risk of VaD among patients with depression. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Depression and the risk of vascular dementia: a population-based retrospective cohort study.
– Name: Author
  Label: Authors
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Wei‐Chen%22&quot;&gt;Lin, Wei‐Chen&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Li‐Yu%22&quot;&gt;Hu, Li‐Yu&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tsai%2C+Shih‐Jen%22&quot;&gt;Tsai, Shih‐Jen&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yang%2C+Albert+C%2E%22&quot;&gt;Yang, Albert C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shen%2C+Cheng‐Che%22&quot;&gt;Shen, Cheng‐Che&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Wei-Chen%22&quot;&gt;Lin, Wei-Chen&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hu%2C+Li-Yu%22&quot;&gt;Hu, Li-Yu&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tsai%2C+Shih-Jen%22&quot;&gt;Tsai, Shih-Jen&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shen%2C+Cheng-Che%22&quot;&gt;Shen, Cheng-Che&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Geriatric+Psychiatry%22&quot;&gt;International Journal of Geriatric Psychiatry&lt;/searchLink&gt;. May2017, Vol. 32 Issue 5, p556-563. 8p.
– Name: Subject
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression+risk+factors%22&quot;&gt;Mental depression risk factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vascular+dementia%22&quot;&gt;Vascular dementia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Coronary+disease%22&quot;&gt;Coronary disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cerebrovascular+disease%22&quot;&gt;Cerebrovascular disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Epidemiology%22&quot;&gt;Epidemiology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Regression+analysis%22&quot;&gt;Regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Disease+risk+factors%22&quot;&gt;Disease risk factors&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: &lt;bold&gt;Objective: &lt;/bold&gt;To examine the association between the risks of depression and vascular dementia (VaD) based on Taiwan&#39;s National Health Insurance Research Database.&lt;bold&gt;Methods: &lt;/bold&gt;This retrospective longitudinal matched-cohort study used National Health Insurance Research Database data from 49,955 participants (9,991 with new onset depression, 39,964 controls). A Cox regression analysis was performed on the whole sample and the subgroup of patients with depression. We further excluded patients who developed VaD within 3 or 5 years after enrollment to evaluate depression as an independent risk factor for or a prodrome of VaD.&lt;bold&gt;Results: &lt;/bold&gt;During the 10-year follow-up period, the incidence rate ratio of VaD between patients with depression and controls was 4.24 [95% confidence interval (CI) 2.90-6.21, P &lt; 0.001]. After adjustment for covariates, the hazard ratio (HR) of VaD in patients with depression was 3.10 (95% CI 2.13-4.52, P &lt; 0.001). In the whole sample, risk factors for VaD besides depression were aged ≥60 years (HR = 20.08), hypertension (HR = 1.70), diabetes (HR = 1.61), coronary artery disease (HR = 2.26), head injury (HR = 2.20), and cerebrovascular disease (HR = 3.02). In patients with depression, aged ≥60 years (HR = 32.16), coronary artery disease (HR = 2.82), head injury (HR = 2.06), and cerebrovascular disease (HR = 2.37) remained risk factors for VaD. After excluding those who developed VaD within 3 or 5 years, HRs remained high (3.28, 95% CI 2.03-5.31, P &lt; 0.001; 2.12, 95% CI 1.05-4.25, P = 0.035, respectively).&lt;bold&gt;Conclusions: &lt;/bold&gt;Our findings suggest that depression is an independent risk factor for subsequent VaD. Older age, cerebrovascular disease, head injury, and coronary artery disease might increase the risk of VaD among patients with depression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/gps.4493
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        Text: English
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        PageCount: 8
        StartPage: 556
    Subjects:
      – SubjectFull: Mental depression risk factors
        Type: general
      – SubjectFull: Vascular dementia
        Type: general
      – SubjectFull: Coronary disease
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      – SubjectFull: Cerebrovascular disease
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      – SubjectFull: Epidemiology
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      – SubjectFull: Regression analysis
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      – SubjectFull: Disease risk factors
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              M: 05
              Text: May2017
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              Y: 2017
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