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Estimates of live birth prevalence of children with Down syndrome in the period 1991-2015 in the Netherlands.

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Title: Estimates of live birth prevalence of children with Down syndrome in the period 1991-2015 in the Netherlands.
Authors: Graaf, G., Engelen, J. J. M., Gijsbers, A. C. J., Hochstenbach, R., Hoffer, M. J. V., Kooper, A. J. A., Sikkema‐Raddatz, B., Srebniak, M. I., Kevie‐Kersemaekers, A. M. F., Zutven, L. J. C. M., Voorhoeve, E.
Source: Journal of Intellectual Disability Research. May2017, Vol. 61 Issue 5, p461-470. 10p. 1 Chart, 1 Graph.
Subjects: Down syndrome, Childbirth, Juvenile diseases, Disease prevalence, Maternal age, Pregnancy, Children, History
Geographic Terms: Netherlands
Abstract: Background In Western countries, increasing maternal age has led to more pregnancies with a child with Down syndrome (DS). However, prenatal screening programs, diagnostic testing and termination of pregnancy influence the actual DS live birth (LB) prevalence as well. The aim of this study is to examine these factors in the Netherlands for the period 1991-2015. In our study, we establish a baseline for DS LB prevalence before non-invasive prenatal testing will be made available to all pregnant women in the Netherlands in 2017. Methods Full nationwide data from the Dutch cytogenetic laboratories were used to evaluate the actual DS LB prevalence. In addition, nonselective DS prevalence, which is the DS LB prevalence that would be expected in absence of termination of pregnancies, was estimated on the basis of maternal age distribution in the general population. Results Because of an increase in maternal age, nonselective DS prevalence increased from around 15.6 [95% confidence interval (CI) 13.9-17.4] per 10 000 LBs in 1991 (311 children in total) to around 22.6 (95% CI 20.3-24.9) per 10 000 in 2015 (385), the increase levelling off in recent years. Actual LB prevalence rose from around 11.6 (95% CI 10.9-12.2) per 10 000 in 1991 (230 children) to an estimated peak of 15.9 (95% CI 15.6-16.2) per 10 000 in 2002 (322), gradually decreasing since to 11.1 (95% CI 10.8-11.5) per 10 000 in 2015 (190). Reduction of DS LBs resulting from elective terminations had been fairly constant between 1995 and 2002 at around 28% and rose afterwards from 35% in 2003 to around 50% in 2015. Conclusions In spite of expansion of antenatal screening in the Netherlands in the 1990s and early 2000s, actual DS LB prevalence increased during this period. However, after 2002, this trend reversed, probably because of informing all pregnant women about prenatal testing since 2004 and the implementation of a national screening program in 2007. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Estimates of live birth prevalence of children with Down syndrome in the period 1991-2015 in the Netherlands.
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  Data: <searchLink fieldCode="AR" term="%22Graaf%2C+G%2E%22">Graaf, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Engelen%2C+J%2E+J%2E+M%2E%22">Engelen, J. J. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gijsbers%2C+A%2E+C%2E+J%2E%22">Gijsbers, A. C. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Hochstenbach%2C+R%2E%22">Hochstenbach, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Hoffer%2C+M%2E+J%2E+V%2E%22">Hoffer, M. J. V.</searchLink><br /><searchLink fieldCode="AR" term="%22Kooper%2C+A%2E+J%2E+A%2E%22">Kooper, A. J. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Sikkema‐Raddatz%2C+B%2E%22">Sikkema‐Raddatz, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Srebniak%2C+M%2E+I%2E%22">Srebniak, M. I.</searchLink><br /><searchLink fieldCode="AR" term="%22Kevie‐Kersemaekers%2C+A%2E+M%2E+F%2E%22">Kevie‐Kersemaekers, A. M. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Zutven%2C+L%2E+J%2E+C%2E+M%2E%22">Zutven, L. J. C. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Voorhoeve%2C+E%2E%22">Voorhoeve, E.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Intellectual+Disability+Research%22">Journal of Intellectual Disability Research</searchLink>. May2017, Vol. 61 Issue 5, p461-470. 10p. 1 Chart, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Childbirth%22">Childbirth</searchLink><br /><searchLink fieldCode="DE" term="%22Juvenile+diseases%22">Juvenile diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+prevalence%22">Disease prevalence</searchLink><br /><searchLink fieldCode="DE" term="%22Maternal+age%22">Maternal age</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22History%22">History</searchLink>
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  Data: Background In Western countries, increasing maternal age has led to more pregnancies with a child with Down syndrome (DS). However, prenatal screening programs, diagnostic testing and termination of pregnancy influence the actual DS live birth (LB) prevalence as well. The aim of this study is to examine these factors in the Netherlands for the period 1991-2015. In our study, we establish a baseline for DS LB prevalence before non-invasive prenatal testing will be made available to all pregnant women in the Netherlands in 2017. Methods Full nationwide data from the Dutch cytogenetic laboratories were used to evaluate the actual DS LB prevalence. In addition, nonselective DS prevalence, which is the DS LB prevalence that would be expected in absence of termination of pregnancies, was estimated on the basis of maternal age distribution in the general population. Results Because of an increase in maternal age, nonselective DS prevalence increased from around 15.6 [95% confidence interval (CI) 13.9-17.4] per 10 000 LBs in 1991 (311 children in total) to around 22.6 (95% CI 20.3-24.9) per 10 000 in 2015 (385), the increase levelling off in recent years. Actual LB prevalence rose from around 11.6 (95% CI 10.9-12.2) per 10 000 in 1991 (230 children) to an estimated peak of 15.9 (95% CI 15.6-16.2) per 10 000 in 2002 (322), gradually decreasing since to 11.1 (95% CI 10.8-11.5) per 10 000 in 2015 (190). Reduction of DS LBs resulting from elective terminations had been fairly constant between 1995 and 2002 at around 28% and rose afterwards from 35% in 2003 to around 50% in 2015. Conclusions In spite of expansion of antenatal screening in the Netherlands in the 1990s and early 2000s, actual DS LB prevalence increased during this period. However, after 2002, this trend reversed, probably because of informing all pregnant women about prenatal testing since 2004 and the implementation of a national screening program in 2007. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=122576918
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