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Familial aggregation in developmental topographical disorientation (DTD).

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Title: Familial aggregation in developmental topographical disorientation (DTD).
Authors: Barclay, Sarah F. (AUTHOR), Burles, Ford (AUTHOR), Potocki, Kendra (AUTHOR), Rancourt, Kate M. (AUTHOR), Nicolson, Mary Lou (AUTHOR), Bech-Hansen, N. Torben (AUTHOR), Iaria, Giuseppe (AUTHOR)
Source: Cognitive Neuropsychology. Oct-Dec2016, Vol. 33 Issue 7/8, p388-397. 10p.
Subjects: Brain damage, Cognitive ability, Familial diseases, Developmental biology, Genetic disorders
Abstract: A variety of brain lesions may affect the ability to orient, resulting in what is termed “acquired topographical disorientation”. In some individuals, however, topographical disorientation is present from childhood, with no apparent brain abnormalities and otherwise intact general cognitive abilities, a condition referred to as “developmental topographical disorientation” (DTD). Individuals affected by DTD often report relatives experiencing the same lifelong orientation difficulties. Here, we sought to assess the familial aggregation of DTD by investigating its occurrence in the families of DTD probands, and in the families of control probands who did not experience topographical disorientation. We found that DTD appears to cluster in the DTD families, with tested relatives displaying the trait, whereas in the control families we did not detect any individuals with DTD. These findings provide the very first evidence for the familial clustering of DTD and motivate further work investigating the genetic factors producing this clustering. [ABSTRACT FROM AUTHOR]
Copyright of Cognitive Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Familial aggregation in developmental topographical disorientation (DTD).
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  Data: <searchLink fieldCode="AR" term="%22Barclay%2C+Sarah+F%2E%22">Barclay, Sarah F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burles%2C+Ford%22">Burles, Ford</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Potocki%2C+Kendra%22">Potocki, Kendra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rancourt%2C+Kate+M%2E%22">Rancourt, Kate M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nicolson%2C+Mary+Lou%22">Nicolson, Mary Lou</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bech-Hansen%2C+N%2E+Torben%22">Bech-Hansen, N. Torben</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iaria%2C+Giuseppe%22">Iaria, Giuseppe</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Cognitive+Neuropsychology%22">Cognitive Neuropsychology</searchLink>. Oct-Dec2016, Vol. 33 Issue 7/8, p388-397. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Brain+damage%22">Brain damage</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink><br /><searchLink fieldCode="DE" term="%22Familial+diseases%22">Familial diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Developmental+biology%22">Developmental biology</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink>
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  Data: A variety of brain lesions may affect the ability to orient, resulting in what is termed “acquired topographical disorientation”. In some individuals, however, topographical disorientation is present from childhood, with no apparent brain abnormalities and otherwise intact general cognitive abilities, a condition referred to as “developmental topographical disorientation” (DTD). Individuals affected by DTD often report relatives experiencing the same lifelong orientation difficulties. Here, we sought to assess the familial aggregation of DTD by investigating its occurrence in the families of DTD probands, and in the families of control probands who did not experience topographical disorientation. We found that DTD appears to cluster in the DTD families, with tested relatives displaying the trait, whereas in the control families we did not detect any individuals with DTD. These findings provide the very first evidence for the familial clustering of DTD and motivate further work investigating the genetic factors producing this clustering. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Cognitive Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/02643294.2016.1262835
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      – Code: eng
        Text: English
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        Type: general
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              Text: Oct-Dec2016
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