View in EDS PDF Full Text

Temperature-dependent Effects of Maternal Separation on Growth, Activity, and Amphetamine Sensitivity in the Rat.

Saved in:
Bibliographic Details
Title: Temperature-dependent Effects of Maternal Separation on Growth, Activity, and Amphetamine Sensitivity in the Rat.
Authors: Zimmerberg, Betty, Shartrand, Angela M.
Source: Developmental Psychobiology. Apr92, Vol. 25 Issue 3, p213-226. 14p.
Subjects: Amphetamines, Appetite depressants, Sympathetic nervous system, Growth, Temperature, Autonomic nervous system
Abstract: This study was conducted to examine the effects of an early stressor. maternal separation, on development, arousal, and sensitivity to amphetamine in the rat. Rat pups were maternally separated at nest temperature (WARM). room temperature (COLD), or nest temperature with agitation (AGIT) for 6 hr each day from 2 to 15 days of age. A control group (CONT) remained with the mother in the nest during this time. COLD subjects were developmentally delayed and had lower body and brain weights than the other three groups into adulthood. WARM and AGIT subjects (both maternally separated at nest temperature) had significant growth delays compared to CONT. but grew more quickly than COLD subjects. COLD subjects were less active than the other maternally separated groups. and WARM and AGIT groups were more active. Activity did not differ at 28 or 75 days of age. However, adult WARM subjects were less sensitive and COLD subjects were more sensitive to amphetamine as measured by locomotor activity than CONT and AGIT subjects, who did not differ from each other. The relationship between early stress, changes in dopaminergic systems, and altered drug responsiveness are discussed in terms of the implications for the etiology of drug abuse. [ABSTRACT FROM AUTHOR]
Copyright of Developmental Psychobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 12288053
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Temperature-dependent Effects of Maternal Separation on Growth, Activity, and Amphetamine Sensitivity in the Rat.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zimmerberg%2C+Betty%22">Zimmerberg, Betty</searchLink><br /><searchLink fieldCode="AR" term="%22Shartrand%2C+Angela+M%2E%22">Shartrand, Angela M.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Developmental+Psychobiology%22">Developmental Psychobiology</searchLink>. Apr92, Vol. 25 Issue 3, p213-226. 14p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink><br /><searchLink fieldCode="DE" term="%22Appetite+depressants%22">Appetite depressants</searchLink><br /><searchLink fieldCode="DE" term="%22Sympathetic+nervous+system%22">Sympathetic nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Growth%22">Growth</searchLink><br /><searchLink fieldCode="DE" term="%22Temperature%22">Temperature</searchLink><br /><searchLink fieldCode="DE" term="%22Autonomic+nervous+system%22">Autonomic nervous system</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study was conducted to examine the effects of an early stressor. maternal separation, on development, arousal, and sensitivity to amphetamine in the rat. Rat pups were maternally separated at nest temperature (WARM). room temperature (COLD), or nest temperature with agitation (AGIT) for 6 hr each day from 2 to 15 days of age. A control group (CONT) remained with the mother in the nest during this time. COLD subjects were developmentally delayed and had lower body and brain weights than the other three groups into adulthood. WARM and AGIT subjects (both maternally separated at nest temperature) had significant growth delays compared to CONT. but grew more quickly than COLD subjects. COLD subjects were less active than the other maternally separated groups. and WARM and AGIT groups were more active. Activity did not differ at 28 or 75 days of age. However, adult WARM subjects were less sensitive and COLD subjects were more sensitive to amphetamine as measured by locomotor activity than CONT and AGIT subjects, who did not differ from each other. The relationship between early stress, changes in dopaminergic systems, and altered drug responsiveness are discussed in terms of the implications for the etiology of drug abuse. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Developmental Psychobiology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=12288053
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/dev.420250306
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 213
    Subjects:
      – SubjectFull: Amphetamines
        Type: general
      – SubjectFull: Appetite depressants
        Type: general
      – SubjectFull: Sympathetic nervous system
        Type: general
      – SubjectFull: Growth
        Type: general
      – SubjectFull: Temperature
        Type: general
      – SubjectFull: Autonomic nervous system
        Type: general
    Titles:
      – TitleFull: Temperature-dependent Effects of Maternal Separation on Growth, Activity, and Amphetamine Sensitivity in the Rat.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zimmerberg, Betty
      – PersonEntity:
          Name:
            NameFull: Shartrand, Angela M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr92
              Type: published
              Y: 1992
          Identifiers:
            – Type: issn-print
              Value: 00121630
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Developmental Psychobiology
              Type: main
ResultId 1