Polymorphisms of IL-17 and ICAM-1 and their expression in Guillain–Barré syndrome.
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| Title: | Polymorphisms of IL-17 and ICAM-1 and their expression in Guillain–Barré syndrome. |
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| Authors: | Kharwar, N.K. (AUTHOR), Prasad, K.N. (AUTHOR), Singh, K. (AUTHOR), Paliwal, V.K. (AUTHOR), Modi, D.R. (AUTHOR) |
| Source: | International Journal of Neuroscience. Aug2017, Vol. 127 Issue 8, p680-687. 8p. |
| Subjects: | Genetic polymorphisms, Interleukin-7, Guillain-Barré syndrome, Cell adhesion molecules, CD54 antigen |
| Abstract: | Purpose: Guillain–Barré syndrome (GBS) is an acute inflammatory, autoimmune disorder of peripheral nervous system. Interleukin-17 (IL-17) and intercellular adhesion molecule-1 (ICAM-1) polymorphisms with higher expression levels have already been studied in many inflammatory and autoimmune diseases. However, the possible role of IL-17 and ICAM-1 polymorphisms in GBS remains unknown. Therefore, the current study investigated IL-17 (His161Arg and Glu126Gly) and ICAM-1 (Gly241Arg) polymorphisms.Materials and method: In this study, total 80 GBS patients and 75 normal healthy controls were included. IL-17 (His161Arg and Glu126Gly) and ICAM-1 (Gly241Arg) polymorphisms were performed using polymerase chain reaction –restriction fragment length polymorphism analysis. Further, the expression of ICAM-1 and IL-17 was determined by reverse-transcriptase PCR and enzyme-linked immunosorbent assay.Results: IL-17 (Glu126Gly) mutant and ICAM-1 (Gly241Arg) heterozygous genotypes were strongly associated with increased risk of GBS (p < 0.016; OR = 3.706, 95% CI = 1.28–10.67;p < 0.001; OR = 4.148, 95% CI = 2.119–8.119, respectively). IL-17 and ICAM-1 genes showed significantly higher expression in GBS when compared with healthy controls.Conclusion: IL-17 and ICAM-1 polymorphisms showed significant association with GBS and their enhanced expressions have possible role in GBS development. IL-17 and ICAM-1 polymorphisms could be genetic markers to GBS susceptibility. [ABSTRACT FROM PUBLISHER] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 122935309 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Polymorphisms of IL-17 and ICAM-1 and their expression in Guillain–Barré syndrome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kharwar%2C+N%2EK%2E%22">Kharwar, N.K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prasad%2C+K%2EN%2E%22">Prasad, K.N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Singh%2C+K%2E%22">Singh, K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paliwal%2C+V%2EK%2E%22">Paliwal, V.K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Modi%2C+D%2ER%2E%22">Modi, D.R.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Aug2017, Vol. 127 Issue 8, p680-687. 8p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukin-7%22">Interleukin-7</searchLink><br /><searchLink fieldCode="DE" term="%22Guillain-Barré+syndrome%22">Guillain-Barré syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+adhesion+molecules%22">Cell adhesion molecules</searchLink><br /><searchLink fieldCode="DE" term="%22CD54+antigen%22">CD54 antigen</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Guillain–Barré syndrome (GBS) is an acute inflammatory, autoimmune disorder of peripheral nervous system. Interleukin-17 (IL-17) and intercellular adhesion molecule-1 (ICAM-1) polymorphisms with higher expression levels have already been studied in many inflammatory and autoimmune diseases. However, the possible role of IL-17 and ICAM-1 polymorphisms in GBS remains unknown. Therefore, the current study investigated IL-17 (His161Arg and Glu126Gly) and ICAM-1 (Gly241Arg) polymorphisms.Materials and method: In this study, total 80 GBS patients and 75 normal healthy controls were included. IL-17 (His161Arg and Glu126Gly) and ICAM-1 (Gly241Arg) polymorphisms were performed using polymerase chain reaction –restriction fragment length polymorphism analysis. Further, the expression of ICAM-1 and IL-17 was determined by reverse-transcriptase PCR and enzyme-linked immunosorbent assay.Results: IL-17 (Glu126Gly) mutant and ICAM-1 (Gly241Arg) heterozygous genotypes were strongly associated with increased risk of GBS (p < 0.016; OR = 3.706, 95% CI = 1.28–10.67;p < 0.001; OR = 4.148, 95% CI = 2.119–8.119, respectively). IL-17 and ICAM-1 genes showed significantly higher expression in GBS when compared with healthy controls.Conclusion: IL-17 and ICAM-1 polymorphisms showed significant association with GBS and their enhanced expressions have possible role in GBS development. IL-17 and ICAM-1 polymorphisms could be genetic markers to GBS susceptibility. [ABSTRACT FROM PUBLISHER] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207454.2016.1231186 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 680 Subjects: – SubjectFull: Genetic polymorphisms Type: general – SubjectFull: Interleukin-7 Type: general – SubjectFull: Guillain-Barré syndrome Type: general – SubjectFull: Cell adhesion molecules Type: general – SubjectFull: CD54 antigen Type: general Titles: – TitleFull: Polymorphisms of IL-17 and ICAM-1 and their expression in Guillain–Barré syndrome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kharwar, N.K. – PersonEntity: Name: NameFull: Prasad, K.N. – PersonEntity: Name: NameFull: Singh, K. – PersonEntity: Name: NameFull: Paliwal, V.K. – PersonEntity: Name: NameFull: Modi, D.R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 127 – Type: issue Value: 8 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
