View in EDS HTML Full Text PDF Full Text

Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.

Saved in:
Bibliographic Details
Title: Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.
Authors: Klatt, Nichole R., Cheu, Ryan, Birse, Kenzie, Zevin, Alexander S., Perner, Michelle, Noël-Romas, Laura, Grobler, Anneke, Westmacott, Garrett, Xie, Irene Y., Mansoor, Lesila, Butler, Jennifer, McKinnon, Lyle R., Passmore, Jo-Ann S., Abdool Karim, Quarraisha, Abdool Karim, Salim S., Burgener, Adam D.
Source: Science (pre-March 2025). 6/1/2017, Vol. 356 Issue 6341, p938-945. 8p. 1 Chart, 14 Graphs.
Subjects: Tenofovir, HIV-positive women, Bactericides, Lactobacillus, Gardnerella
Abstract: Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women. We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in the CAPRISA (Centre for the AIDS Program of Research in South Africa) 004 trial.Two major vaginal bacterial community types—one dominated by Lactobacillus (59.2%) and the other where Gardnerella vaginalis predominated with other anaerobic bacteria (40.8%)—were identified in 688 women profiled. Tenofovir reduced HIV incidence by 61%(P = 0.013) in Lactobacillus-dominant women but only 18% (P = 0.644) in women with non-Lactobacillus bacteria, a threefold difference in efficacy. Detectible mucosal tenofovir was lower in non-Lactobacillus women, negatively correlating with G. vaginalis and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly than target cells convert to pharmacologically active drug. This study provides evidence linking vaginal bacteria to microbicide efficacy through tenofovir depletion via bacterial metabolism. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 123391156
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Klatt%2C+Nichole+R%2E%22">Klatt, Nichole R.</searchLink><br /><searchLink fieldCode="AR" term="%22Cheu%2C+Ryan%22">Cheu, Ryan</searchLink><br /><searchLink fieldCode="AR" term="%22Birse%2C+Kenzie%22">Birse, Kenzie</searchLink><br /><searchLink fieldCode="AR" term="%22Zevin%2C+Alexander+S%2E%22">Zevin, Alexander S.</searchLink><br /><searchLink fieldCode="AR" term="%22Perner%2C+Michelle%22">Perner, Michelle</searchLink><br /><searchLink fieldCode="AR" term="%22Noël-Romas%2C+Laura%22">Noël-Romas, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Grobler%2C+Anneke%22">Grobler, Anneke</searchLink><br /><searchLink fieldCode="AR" term="%22Westmacott%2C+Garrett%22">Westmacott, Garrett</searchLink><br /><searchLink fieldCode="AR" term="%22Xie%2C+Irene+Y%2E%22">Xie, Irene Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Mansoor%2C+Lesila%22">Mansoor, Lesila</searchLink><br /><searchLink fieldCode="AR" term="%22Butler%2C+Jennifer%22">Butler, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22McKinnon%2C+Lyle+R%2E%22">McKinnon, Lyle R.</searchLink><br /><searchLink fieldCode="AR" term="%22Passmore%2C+Jo-Ann+S%2E%22">Passmore, Jo-Ann S.</searchLink><br /><searchLink fieldCode="AR" term="%22Abdool+Karim%2C+Quarraisha%22">Abdool Karim, Quarraisha</searchLink><br /><searchLink fieldCode="AR" term="%22Abdool+Karim%2C+Salim+S%2E%22">Abdool Karim, Salim S.</searchLink><br /><searchLink fieldCode="AR" term="%22Burgener%2C+Adam+D%2E%22">Burgener, Adam D.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/1/2017, Vol. 356 Issue 6341, p938-945. 8p. 1 Chart, 14 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Tenofovir%22">Tenofovir</searchLink><br /><searchLink fieldCode="DE" term="%22HIV-positive+women%22">HIV-positive women</searchLink><br /><searchLink fieldCode="DE" term="%22Bactericides%22">Bactericides</searchLink><br /><searchLink fieldCode="DE" term="%22Lactobacillus%22">Lactobacillus</searchLink><br /><searchLink fieldCode="DE" term="%22Gardnerella%22">Gardnerella</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Antiretroviral-based strategies for HIV prevention have shown inconsistent results in women. We investigated whether vaginal microbiota modulated tenofovir gel microbicide efficacy in the CAPRISA (Centre for the AIDS Program of Research in South Africa) 004 trial.Two major vaginal bacterial community types—one dominated by Lactobacillus (59.2%) and the other where Gardnerella vaginalis predominated with other anaerobic bacteria (40.8%)—were identified in 688 women profiled. Tenofovir reduced HIV incidence by 61%(P = 0.013) in Lactobacillus-dominant women but only 18% (P = 0.644) in women with non-Lactobacillus bacteria, a threefold difference in efficacy. Detectible mucosal tenofovir was lower in non-Lactobacillus women, negatively correlating with G. vaginalis and other anaerobic bacteria, which depleted tenofovir by metabolism more rapidly than target cells convert to pharmacologically active drug. This study provides evidence linking vaginal bacteria to microbicide efficacy through tenofovir depletion via bacterial metabolism. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=123391156
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.aai9383
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 938
    Subjects:
      – SubjectFull: Tenofovir
        Type: general
      – SubjectFull: HIV-positive women
        Type: general
      – SubjectFull: Bactericides
        Type: general
      – SubjectFull: Lactobacillus
        Type: general
      – SubjectFull: Gardnerella
        Type: general
    Titles:
      – TitleFull: Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Klatt, Nichole R.
      – PersonEntity:
          Name:
            NameFull: Cheu, Ryan
      – PersonEntity:
          Name:
            NameFull: Birse, Kenzie
      – PersonEntity:
          Name:
            NameFull: Zevin, Alexander S.
      – PersonEntity:
          Name:
            NameFull: Perner, Michelle
      – PersonEntity:
          Name:
            NameFull: Noël-Romas, Laura
      – PersonEntity:
          Name:
            NameFull: Grobler, Anneke
      – PersonEntity:
          Name:
            NameFull: Westmacott, Garrett
      – PersonEntity:
          Name:
            NameFull: Xie, Irene Y.
      – PersonEntity:
          Name:
            NameFull: Mansoor, Lesila
      – PersonEntity:
          Name:
            NameFull: Butler, Jennifer
      – PersonEntity:
          Name:
            NameFull: McKinnon, Lyle R.
      – PersonEntity:
          Name:
            NameFull: Passmore, Jo-Ann S.
      – PersonEntity:
          Name:
            NameFull: Abdool Karim, Quarraisha
      – PersonEntity:
          Name:
            NameFull: Abdool Karim, Salim S.
      – PersonEntity:
          Name:
            NameFull: Burgener, Adam D.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 06
              Text: 6/1/2017
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 356
            – Type: issue
              Value: 6341
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1