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Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.

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Title: Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
Authors: Botoseneanu, Anda, Chen, Haiying, Ambrosius, Walter T., Allore, Heather G., Anton, Stephen, Folta, Sara C., King, Abby C., Nicklas, Barbara J., Spring, Bonnie J., Strotmeyer, Elsa S., Gill, Thomas M.
Source: Journal of the American Geriatrics Society. Jun2017, Vol. 65 Issue 6, p1244-1250. 7p. 1 Chart, 2 Graphs.
Subjects: Metabolic syndrome risk factors, Physical activity, Mobility of older people, Lifestyles & health, Walking, Older people with disabilities, Health, Physiology, Health behavior, Randomized controlled trials, Behavior modification, Confidence intervals, Movement disorders, Probability theory, Metabolic syndrome
Abstract: Objectives To test whether structured physical activity ( PA) is associated with a greater reduction in major mobility disability ( MMD) in older persons with metabolic syndrome (MetS) than in those without. Design Data from the Lifestyle Interventions and Independence for Elders ( LIFE) Study, a multicenter randomized trial of 1,635 persons with assessments every 6 months (average 2.7 years). Setting Eight U.S. centers. Participants Sedentary men and women aged 70 to 89 with functional limitations (N = 1,535); 100 participants were excluded because of missing MetS data. Intervention Participants were randomized to a moderate-intensity PA program (n = 766) or a health education program (n = 769). Measurements MetS was defined according to the 2009 multiagency harmonized criteria. Outcomes included incident MMD (loss of ability to walk 400 m) and persistent MMD (two consecutive MMD diagnoses or one MMD diagnosis followed by death). Results Seven hundred sixty-three (49.7%) participants met criteria for MetS. PA reduced incident MMD more than health education did in participants with MetS (hazard ratio ( HR) = 0.72, 95% confidence interval ( CI) = 0.57-0.91, P = .007) but not in those without MetS ( HR = 0.96, 95% CI = 0.73-1.25, P = .75); the test for statistical interaction was not significant ( P = .13). PA reduced the risk of persistent MMD in participants with MetS ( HR = 0.57, 95% CI = 0.41-0.79, P < .001) but not in those without MetS ( HR = 0.97, 95% CI = 0.67-1.41, P = .87). The test for statistical interaction was significant ( P = .04). Conclusion Moderate-intensity PA substantially reduces the risk of persistent MMD in older persons with functional limitations with MetS but not in those without MetS. Comparable results were observed for incident MMD. The LIFE PA program may be an effective strategy for reducing mobility disability in vulnerable older persons with MetS. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Botoseneanu%2C+Anda%22&quot;&gt;Botoseneanu, Anda&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Haiying%22&quot;&gt;Chen, Haiying&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ambrosius%2C+Walter+T%2E%22&quot;&gt;Ambrosius, Walter T.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Allore%2C+Heather+G%2E%22&quot;&gt;Allore, Heather G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Anton%2C+Stephen%22&quot;&gt;Anton, Stephen&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Folta%2C+Sara+C%2E%22&quot;&gt;Folta, Sara C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22King%2C+Abby+C%2E%22&quot;&gt;King, Abby C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nicklas%2C+Barbara+J%2E%22&quot;&gt;Nicklas, Barbara J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Spring%2C+Bonnie+J%2E%22&quot;&gt;Spring, Bonnie J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strotmeyer%2C+Elsa+S%2E%22&quot;&gt;Strotmeyer, Elsa S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gill%2C+Thomas+M%2E%22&quot;&gt;Gill, Thomas M.&lt;/searchLink&gt;
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– Name: Abstract
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  Data: Objectives To test whether structured physical activity ( PA) is associated with a greater reduction in major mobility disability ( MMD) in older persons with metabolic syndrome (MetS) than in those without. Design Data from the Lifestyle Interventions and Independence for Elders ( LIFE) Study, a multicenter randomized trial of 1,635 persons with assessments every 6 months (average 2.7 years). Setting Eight U.S. centers. Participants Sedentary men and women aged 70 to 89 with functional limitations (N = 1,535); 100 participants were excluded because of missing MetS data. Intervention Participants were randomized to a moderate-intensity PA program (n = 766) or a health education program (n = 769). Measurements MetS was defined according to the 2009 multiagency harmonized criteria. Outcomes included incident MMD (loss of ability to walk 400 m) and persistent MMD (two consecutive MMD diagnoses or one MMD diagnosis followed by death). Results Seven hundred sixty-three (49.7%) participants met criteria for MetS. PA reduced incident MMD more than health education did in participants with MetS (hazard ratio ( HR) = 0.72, 95% confidence interval ( CI) = 0.57-0.91, P = .007) but not in those without MetS ( HR = 0.96, 95% CI = 0.73-1.25, P = .75); the test for statistical interaction was not significant ( P = .13). PA reduced the risk of persistent MMD in participants with MetS ( HR = 0.57, 95% CI = 0.41-0.79, P &lt; .001) but not in those without MetS ( HR = 0.97, 95% CI = 0.67-1.41, P = .87). The test for statistical interaction was significant ( P = .04). Conclusion Moderate-intensity PA substantially reduces the risk of persistent MMD in older persons with functional limitations with MetS but not in those without MetS. Comparable results were observed for incident MMD. The LIFE PA program may be an effective strategy for reducing mobility disability in vulnerable older persons with MetS. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Journal of the American Geriatrics Society is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=123692389
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        Value: 10.1111/jgs.14793
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 1244
    Subjects:
      – SubjectFull: Metabolic syndrome risk factors
        Type: general
      – SubjectFull: Physical activity
        Type: general
      – SubjectFull: Mobility of older people
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      – SubjectFull: Lifestyles & health
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      – SubjectFull: Older people with disabilities
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      – SubjectFull: Health
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      – SubjectFull: Physiology
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      – SubjectFull: Health behavior
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      – SubjectFull: Randomized controlled trials
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      – SubjectFull: Behavior modification
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Probability theory
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      – SubjectFull: Metabolic syndrome
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      – TitleFull: Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention-The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial.
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