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Platelet [³]-Paroxetine Binding in Obsessive-Compulsive Disorder.

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Title: Platelet [³]-Paroxetine Binding in Obsessive-Compulsive Disorder.
Authors: Maguire, Kay P., Norman, Trevor R., Apostolopoulos, Maria, Judd, Flona K., Burrows, Graham D.
Source: Human Psychopharmacology: Clinical & Experimental. Mar/Apr95, Vol. 10 Issue 2, p141-146. 6p.
Subjects: Obsessive-compulsive disorder, Blood platelets, Proteins, Blood cells, Analysis of covariance, Serotonin, Patients
Abstract: Platelet [³H]-paroxetine binding was analysed in 26 patients (13F, 13M) with obsessive compulsive disorder and 26 normal controls (I3F. I3M). For patients with obsessive compulsive disorder, Bmax was 2127 ± 480 fmoI/mg protein (mean ± SD) compared to control Bmax values of 1926 ± 696 fmol/mg protein. The mean Ka value for the patients was 0.075 ± 0.025 nm and for the controls was 0.076 ± 0.032 nM. Analysis of covariance indicated a significant effect of sex on both Bd and Bmax but no effect of diagnosis (obsessive compulsive disorder versus normal controls) or season of sampling. The data provide no evidence for an abnormality an the platelet uptake mechanism as assessed by the measurement of [³H]-paroxetine binding to the platelet transporter in obsessive compulsive disorder. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Platelet [³]-Paroxetine Binding in Obsessive-Compulsive Disorder.
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  Data: <searchLink fieldCode="AR" term="%22Maguire%2C+Kay+P%2E%22">Maguire, Kay P.</searchLink><br /><searchLink fieldCode="AR" term="%22Norman%2C+Trevor+R%2E%22">Norman, Trevor R.</searchLink><br /><searchLink fieldCode="AR" term="%22Apostolopoulos%2C+Maria%22">Apostolopoulos, Maria</searchLink><br /><searchLink fieldCode="AR" term="%22Judd%2C+Flona+K%2E%22">Judd, Flona K.</searchLink><br /><searchLink fieldCode="AR" term="%22Burrows%2C+Graham+D%2E%22">Burrows, Graham D.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Mar/Apr95, Vol. 10 Issue 2, p141-146. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+platelets%22">Blood platelets</searchLink><br /><searchLink fieldCode="DE" term="%22Proteins%22">Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+cells%22">Blood cells</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+covariance%22">Analysis of covariance</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: Platelet [³H]-paroxetine binding was analysed in 26 patients (13F, 13M) with obsessive compulsive disorder and 26 normal controls (I3F. I3M). For patients with obsessive compulsive disorder, Bmax was 2127 ± 480 fmoI/mg protein (mean ± SD) compared to control Bmax values of 1926 ± 696 fmol/mg protein. The mean Ka value for the patients was 0.075 ± 0.025 nm and for the controls was 0.076 ± 0.032 nM. Analysis of covariance indicated a significant effect of sex on both Bd and Bmax but no effect of diagnosis (obsessive compulsive disorder versus normal controls) or season of sampling. The data provide no evidence for an abnormality an the platelet uptake mechanism as assessed by the measurement of [³H]-paroxetine binding to the platelet transporter in obsessive compulsive disorder. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1002/hup.470100209
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 141
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      – SubjectFull: Obsessive-compulsive disorder
        Type: general
      – SubjectFull: Blood platelets
        Type: general
      – SubjectFull: Proteins
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      – SubjectFull: Blood cells
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      – SubjectFull: Analysis of covariance
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            NameFull: Norman, Trevor R.
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            NameFull: Apostolopoulos, Maria
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            NameFull: Judd, Flona K.
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              Text: Mar/Apr95
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              Y: 1995
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