Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort.
Saved in:
| Title: | Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. |
|---|---|
| Authors: | Fond, G., Berna, F., Andrianarisoa, M., Godin, O., Leboyer, M., Brunel, L., Aouizerate, B., Capdevielle, D., Chereau, I., D'Amato, T., Denizot, H., Dubertret, C., Dubreucq, J., Faget, C., Gabayet, F., Llorca, P., Mallet, J., Misdrahi, D., Passerieux, C., Richieri, R. |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Aug2017, Vol. 267 Issue 5, p465-472. 8p. 1 Chart. |
| Subjects: | Nicotine addiction, Inflammation, Schizophrenia treatment, Mild cognitive impairment, Alcohol drinking, Smoking cessation, Cohort analysis |
| Abstract: | Chronic peripheral inflammation (CPI) has been associated with cognitive impairment in schizophrenia (SZ). However, its sources remain unclear, more specifically it is not known whether tobacco smoking is a source of inflammation or not in SZ subjects. Moreover, nicotine (NIC), the major psychoactive compound of tobacco, shows strong anti-inflammatory properties in vitro, as well as inducing a severe biological dependence when administered repeatedly. The objective of the present study was to determine if CPI was associated with tobacco smoking and/or NIC dependence in schizophrenia. Three hundred and forty five stabilized community-dwelling SZ subjects aged 16 years or older (mean age = 32 years, 73% male) were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and assessed with validated scales. CPI was defined by a highly sensitive C-reactive protein (hsCRP) ≥3 mg/L. Current tobacco status was self-declared. Severe NIC dependence was defined by a Fagerstrom Test for Nicotine Dependence score ≥7. Overall, 159 (46.1%) were non-smokers, 117 (33.9%) and 69 (20%) were current tobacco smokers with, respectively, low and severe nicotine dependence. In a multivariate model, CPI remained associated with severe NIC dependence (29 vs 15%, OR = 2.8, p = 0.003) and body mass index (OR = 1.1, p < 0.0001), independently of socio-demographic characteristics and antidepressant intake. No association of CPI with low to moderate tobacco smoking dependence, number of daily smoked cigarettes, cannabis use, alcohol use or illness characteristics was found (all p > 0.05). CPI was associated with severe NIC dependence but not with tobacco smoking with low to moderate NIC dependence in SZ, independently of socio-demographic variables, body mass index, alcohol consumption and antidepressant intake. This result highlights the potential CPI consequences of the high prevalence of heavy tobacco smoking in SZ, indicating the importance of new therapeutic strategies for tobacco cessation in SZ. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 124090345 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Fond%2C+G%2E%22">Fond, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Berna%2C+F%2E%22">Berna, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Andrianarisoa%2C+M%2E%22">Andrianarisoa, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Godin%2C+O%2E%22">Godin, O.</searchLink><br /><searchLink fieldCode="AR" term="%22Leboyer%2C+M%2E%22">Leboyer, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Brunel%2C+L%2E%22">Brunel, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Aouizerate%2C+B%2E%22">Aouizerate, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Capdevielle%2C+D%2E%22">Capdevielle, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Chereau%2C+I%2E%22">Chereau, I.</searchLink><br /><searchLink fieldCode="AR" term="%22D'Amato%2C+T%2E%22">D'Amato, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Denizot%2C+H%2E%22">Denizot, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Dubertret%2C+C%2E%22">Dubertret, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Dubreucq%2C+J%2E%22">Dubreucq, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Faget%2C+C%2E%22">Faget, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Gabayet%2C+F%2E%22">Gabayet, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Llorca%2C+P%2E%22">Llorca, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Mallet%2C+J%2E%22">Mallet, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Misdrahi%2C+D%2E%22">Misdrahi, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Passerieux%2C+C%2E%22">Passerieux, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Richieri%2C+R%2E%22">Richieri, R.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Aug2017, Vol. 267 Issue 5, p465-472. 8p. 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nicotine+addiction%22">Nicotine addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia+treatment%22">Schizophrenia treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Mild+cognitive+impairment%22">Mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking+cessation%22">Smoking cessation</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Chronic peripheral inflammation (CPI) has been associated with cognitive impairment in schizophrenia (SZ). However, its sources remain unclear, more specifically it is not known whether tobacco smoking is a source of inflammation or not in SZ subjects. Moreover, nicotine (NIC), the major psychoactive compound of tobacco, shows strong anti-inflammatory properties in vitro, as well as inducing a severe biological dependence when administered repeatedly. The objective of the present study was to determine if CPI was associated with tobacco smoking and/or NIC dependence in schizophrenia. Three hundred and forty five stabilized community-dwelling SZ subjects aged 16 years or older (mean age = 32 years, 73% male) were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and assessed with validated scales. CPI was defined by a highly sensitive C-reactive protein (hsCRP) ≥3 mg/L. Current tobacco status was self-declared. Severe NIC dependence was defined by a Fagerstrom Test for Nicotine Dependence score ≥7. Overall, 159 (46.1%) were non-smokers, 117 (33.9%) and 69 (20%) were current tobacco smokers with, respectively, low and severe nicotine dependence. In a multivariate model, CPI remained associated with severe NIC dependence (29 vs 15%, OR = 2.8, p = 0.003) and body mass index (OR = 1.1, p < 0.0001), independently of socio-demographic characteristics and antidepressant intake. No association of CPI with low to moderate tobacco smoking dependence, number of daily smoked cigarettes, cannabis use, alcohol use or illness characteristics was found (all p > 0.05). CPI was associated with severe NIC dependence but not with tobacco smoking with low to moderate NIC dependence in SZ, independently of socio-demographic variables, body mass index, alcohol consumption and antidepressant intake. This result highlights the potential CPI consequences of the high prevalence of heavy tobacco smoking in SZ, indicating the importance of new therapeutic strategies for tobacco cessation in SZ. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=124090345 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00406-017-0771-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 465 Subjects: – SubjectFull: Nicotine addiction Type: general – SubjectFull: Inflammation Type: general – SubjectFull: Schizophrenia treatment Type: general – SubjectFull: Mild cognitive impairment Type: general – SubjectFull: Alcohol drinking Type: general – SubjectFull: Smoking cessation Type: general – SubjectFull: Cohort analysis Type: general Titles: – TitleFull: Chronic low-grade peripheral inflammation is associated with severe nicotine dependence in schizophrenia: results from the national multicentric FACE-SZ cohort. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Fond, G. – PersonEntity: Name: NameFull: Berna, F. – PersonEntity: Name: NameFull: Andrianarisoa, M. – PersonEntity: Name: NameFull: Godin, O. – PersonEntity: Name: NameFull: Leboyer, M. – PersonEntity: Name: NameFull: Brunel, L. – PersonEntity: Name: NameFull: Aouizerate, B. – PersonEntity: Name: NameFull: Capdevielle, D. – PersonEntity: Name: NameFull: Chereau, I. – PersonEntity: Name: NameFull: D'Amato, T. – PersonEntity: Name: NameFull: Denizot, H. – PersonEntity: Name: NameFull: Dubertret, C. – PersonEntity: Name: NameFull: Dubreucq, J. – PersonEntity: Name: NameFull: Faget, C. – PersonEntity: Name: NameFull: Gabayet, F. – PersonEntity: Name: NameFull: Llorca, P. – PersonEntity: Name: NameFull: Mallet, J. – PersonEntity: Name: NameFull: Misdrahi, D. – PersonEntity: Name: NameFull: Passerieux, C. – PersonEntity: Name: NameFull: Richieri, R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 08 Text: Aug2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 09401334 Numbering: – Type: volume Value: 267 – Type: issue Value: 5 Titles: – TitleFull: European Archives of Psychiatry & Clinical Neuroscience Type: main |
| ResultId | 1 |
