Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats.
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| Title: | Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats. |
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| Authors: | Xu, Haiyang, Das, Sasmita, Sturgill, Marc, Hodgkinson, Colin, Yuan, Qiaoping, Goldman, David, Grasing, Kenneth |
| Source: | Psychopharmacology. Aug2017, Vol. 234 Issue 16, p2475-2487. 13p. 1 Diagram, 3 Charts, 4 Graphs. |
| Subjects: | Dopamine receptors, Extracellular matrix, Cocaine & psychology, Cholinergic receptors, Microdialysis, Neurotransmitters, Laboratory rats |
| Abstract: | Rationale: The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of breeding. Objective: The objective of the present study is to compare cocaine preference, neurotransmitter release, and dopamine receptor activation in LS and HS rats. Methods: Levels of dopamine, acetylcholine, and cocaine were measured in the nucleus accumbens (NA) shell of HS and LS rats by tandem mass spectrometry of microdialysates. Cocaine-induced locomotor activity and conditioned-place preference were compared between LS and HS rats. Results: HS rats displayed greater conditioned-place preference scores compared to LS and reduced basal extracellular concentrations of dopamine and acetylcholine. However, patterns of neurotransmitter release did not differ between strains. Low-dose cocaine increased locomotor activity in LS rats, but not in HS animals, while high-dose cocaine augmented activity only in HS rats. Either dose of cocaine increased immunoreactivity for c-Fos in the NA shell of both strains, with greater elevations observed in HS rats. Activation identified by cells expressing both c-Fos and dopamine receptors was generally greater in the HS strain, with a similar pattern for both D1 and D2 dopamine receptors. Conclusions: Diminished levels of dopamine and acetylcholine in the NA shell, with enhanced cocaine-induced expression of D1 and D2 receptors, are associated with greater rewarding effects of cocaine in HS rats and an altered dose-effect relationship for cocaine-induced locomotor activity. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 124395656 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Xu%2C+Haiyang%22">Xu, Haiyang</searchLink><br /><searchLink fieldCode="AR" term="%22Das%2C+Sasmita%22">Das, Sasmita</searchLink><br /><searchLink fieldCode="AR" term="%22Sturgill%2C+Marc%22">Sturgill, Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Hodgkinson%2C+Colin%22">Hodgkinson, Colin</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan%2C+Qiaoping%22">Yuan, Qiaoping</searchLink><br /><searchLink fieldCode="AR" term="%22Goldman%2C+David%22">Goldman, David</searchLink><br /><searchLink fieldCode="AR" term="%22Grasing%2C+Kenneth%22">Grasing, Kenneth</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Aug2017, Vol. 234 Issue 16, p2475-2487. 13p. 1 Diagram, 3 Charts, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Extracellular+matrix%22">Extracellular matrix</searchLink><br /><searchLink fieldCode="DE" term="%22Cocaine+%26+psychology%22">Cocaine & psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+receptors%22">Cholinergic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Microdialysis%22">Microdialysis</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Rationale: The low self-administration (LS)/Kgras (LS) and high self-administration (HS)/Kgras (HS) rat lines were generated by selective breeding for low- and high-intravenous cocaine self-administration, respectively, from a common outbred Wistar stock (Crl:WI). This trait has remained stable after 13 generations of breeding. Objective: The objective of the present study is to compare cocaine preference, neurotransmitter release, and dopamine receptor activation in LS and HS rats. Methods: Levels of dopamine, acetylcholine, and cocaine were measured in the nucleus accumbens (NA) shell of HS and LS rats by tandem mass spectrometry of microdialysates. Cocaine-induced locomotor activity and conditioned-place preference were compared between LS and HS rats. Results: HS rats displayed greater conditioned-place preference scores compared to LS and reduced basal extracellular concentrations of dopamine and acetylcholine. However, patterns of neurotransmitter release did not differ between strains. Low-dose cocaine increased locomotor activity in LS rats, but not in HS animals, while high-dose cocaine augmented activity only in HS rats. Either dose of cocaine increased immunoreactivity for c-Fos in the NA shell of both strains, with greater elevations observed in HS rats. Activation identified by cells expressing both c-Fos and dopamine receptors was generally greater in the HS strain, with a similar pattern for both D1 and D2 dopamine receptors. Conclusions: Diminished levels of dopamine and acetylcholine in the NA shell, with enhanced cocaine-induced expression of D1 and D2 receptors, are associated with greater rewarding effects of cocaine in HS rats and an altered dose-effect relationship for cocaine-induced locomotor activity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-017-4640-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 2475 Subjects: – SubjectFull: Dopamine receptors Type: general – SubjectFull: Extracellular matrix Type: general – SubjectFull: Cocaine & psychology Type: general – SubjectFull: Cholinergic receptors Type: general – SubjectFull: Microdialysis Type: general – SubjectFull: Neurotransmitters Type: general – SubjectFull: Laboratory rats Type: general Titles: – TitleFull: Extracellular dopamine, acetylcholine, and activation of dopamine D1 and D2 receptors after selective breeding for cocaine self-administration in rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Xu, Haiyang – PersonEntity: Name: NameFull: Das, Sasmita – PersonEntity: Name: NameFull: Sturgill, Marc – PersonEntity: Name: NameFull: Hodgkinson, Colin – PersonEntity: Name: NameFull: Yuan, Qiaoping – PersonEntity: Name: NameFull: Goldman, David – PersonEntity: Name: NameFull: Grasing, Kenneth IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 08 Text: Aug2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 234 – Type: issue Value: 16 Titles: – TitleFull: Psychopharmacology Type: main |
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