Longitudinal development of cognitive, visuomotor and adaptive behavior skills in HIV uninfected children, aged 3–5 years of age, exposed pre- and perinatally to anti-retroviral medications.
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| Title: | Longitudinal development of cognitive, visuomotor and adaptive behavior skills in HIV uninfected children, aged 3–5 years of age, exposed pre- and perinatally to anti-retroviral medications. |
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| Authors: | Smith, Mary Lou (AUTHOR), Puka, Klajdi (AUTHOR), Sehra, Ramandeep (AUTHOR), Read, Stanley E. (AUTHOR), Bitnun, Ari (AUTHOR) |
| Source: | AIDS Care. Oct2017, Vol. 29 Issue 10, p1302-1308. 7p. |
| Subjects: | Antiretroviral agents, Child development, Cognition in children, HIV infections, Intellect, Longitudinal method, Mothers, Children |
| Abstract: | Little is known about the neurodevelopmental outcomes of children older than 3 years of age born to HIV infected mother but who are HIV-uninfected (HEU), and who have been exposed in utero and early in life to HIV and to antiretroviral medications (ARVs). We conducted a longitudinal study of cognitive, visuomotor and adaptive function of HEU children, who were assessed at two ages, 3.5 and 5.5 years. Sixty-four children (33 female) were assessed. In comparison with population norms for their age, at 3.5 years of age they had scores significantly below age expectations on aspects of adaptive behavior, but at age 5.5 years, their scores did not significantly diverge from the population norms on any of the measures. Verbal intelligence was lower at age 5.5 than at age 3.5 years, although there were also improvements in some features of adaptive behavior. Exposure to PI-based ARVs (compared to NNRTIs) was associated with higher Performance IQ, visuomotor and communication scores at age 5.5 years. Birth, early growth, and sociodemographic variables were predictive of outcomes. This study is important in tracking the trajectory of neurocognitive development across the pre-school and early school age years. The findings suggest that the full impact of early ARV exposure may not be evident until a considerable period of development has occurred. The results raise the possibility of negative effects of early ARV exposure on neurodevelopment that emerge over time, and reiterate the importance of sociodemographic and early health variables for optimal development. [ABSTRACT FROM PUBLISHER] |
| Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 124435088 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Longitudinal development of cognitive, visuomotor and adaptive behavior skills in HIV uninfected children, aged 3–5 years of age, exposed pre- and perinatally to anti-retroviral medications. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Smith%2C+Mary+Lou%22">Smith, Mary Lou</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Puka%2C+Klajdi%22">Puka, Klajdi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sehra%2C+Ramandeep%22">Sehra, Ramandeep</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Read%2C+Stanley+E%2E%22">Read, Stanley E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bitnun%2C+Ari%22">Bitnun, Ari</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Oct2017, Vol. 29 Issue 10, p1302-1308. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Antiretroviral+agents%22">Antiretroviral agents</searchLink><br /><searchLink fieldCode="DE" term="%22Child+development%22">Child development</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition+in+children%22">Cognition in children</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Intellect%22">Intellect</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Little is known about the neurodevelopmental outcomes of children older than 3 years of age born to HIV infected mother but who are HIV-uninfected (HEU), and who have been exposed in utero and early in life to HIV and to antiretroviral medications (ARVs). We conducted a longitudinal study of cognitive, visuomotor and adaptive function of HEU children, who were assessed at two ages, 3.5 and 5.5 years. Sixty-four children (33 female) were assessed. In comparison with population norms for their age, at 3.5 years of age they had scores significantly below age expectations on aspects of adaptive behavior, but at age 5.5 years, their scores did not significantly diverge from the population norms on any of the measures. Verbal intelligence was lower at age 5.5 than at age 3.5 years, although there were also improvements in some features of adaptive behavior. Exposure to PI-based ARVs (compared to NNRTIs) was associated with higher Performance IQ, visuomotor and communication scores at age 5.5 years. Birth, early growth, and sociodemographic variables were predictive of outcomes. This study is important in tracking the trajectory of neurocognitive development across the pre-school and early school age years. The findings suggest that the full impact of early ARV exposure may not be evident until a considerable period of development has occurred. The results raise the possibility of negative effects of early ARV exposure on neurodevelopment that emerge over time, and reiterate the importance of sociodemographic and early health variables for optimal development. [ABSTRACT FROM PUBLISHER] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/09540121.2017.1325436 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1302 Subjects: – SubjectFull: Antiretroviral agents Type: general – SubjectFull: Child development Type: general – SubjectFull: Cognition in children Type: general – SubjectFull: HIV infections Type: general – SubjectFull: Intellect Type: general – SubjectFull: Longitudinal method Type: general – SubjectFull: Mothers Type: general – SubjectFull: Children Type: general Titles: – TitleFull: Longitudinal development of cognitive, visuomotor and adaptive behavior skills in HIV uninfected children, aged 3–5 years of age, exposed pre- and perinatally to anti-retroviral medications. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Smith, Mary Lou – PersonEntity: Name: NameFull: Puka, Klajdi – PersonEntity: Name: NameFull: Sehra, Ramandeep – PersonEntity: Name: NameFull: Read, Stanley E. – PersonEntity: Name: NameFull: Bitnun, Ari IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 09540121 Numbering: – Type: volume Value: 29 – Type: issue Value: 10 Titles: – TitleFull: AIDS Care Type: main |
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