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Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders.

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Title: Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders.
Authors: Fattori, A., Neri, L., Bellomo, A., Vaggi, M., Mencacci, C., ILDE Study Group (CORPORATE AUTHOR)
Source: Quality of Life Research. Sep2017, Vol. 26 Issue 9, p2459-2469. 11p. 2 Charts, 2 Graphs.
Subjects: Mental illness, Quality of life, Sociodemographic factors, Cognitive ability, Medical databases, Mental health, Mental depression, Questionnaires
Abstract: Purpose: Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL.Methods: Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information). A psychiatrist completed a standardized data collection form encompassing a depression severity scale (MADRS) and clinical information.Results: There was a strong graded association between the severity of depressive symptoms and both the physical (ω 2 = 0.13; p < 0.01) and mental (ω 2 = 0.34; p < 0.01) SF-12 domains. Additionally, we observed a strong association between concentration difficulties and all HRQOL outcomes independent of other symptoms of depression and robust to adjustment for possible confounders.Conclusions: Our data corroborate previous findings suggesting that cognitive impairment is a feature of unipolar depressive disorders partially independent of the severity of other symptoms, and may represent a specific target of therapy with a strong impact on patients' functioning and quality of life. [ABSTRACT FROM AUTHOR]
Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Depression severity and concentration difficulties are independently associated with HRQOL in patients with unipolar depressive disorders.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fattori%2C+A%2E%22&quot;&gt;Fattori, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Neri%2C+L%2E%22&quot;&gt;Neri, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bellomo%2C+A%2E%22&quot;&gt;Bellomo, A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vaggi%2C+M%2E%22&quot;&gt;Vaggi, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mencacci%2C+C%2E%22&quot;&gt;Mencacci, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22ILDE+Study+Group%22&quot;&gt;ILDE Study Group&lt;/searchLink&gt; (CORPORATE AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Quality+of+Life+Research%22&quot;&gt;Quality of Life Research&lt;/searchLink&gt;. Sep2017, Vol. 26 Issue 9, p2459-2469. 11p. 2 Charts, 2 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+illness%22&quot;&gt;Mental illness&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Quality+of+life%22&quot;&gt;Quality of life&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Sociodemographic+factors%22&quot;&gt;Sociodemographic factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cognitive+ability%22&quot;&gt;Cognitive ability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+databases%22&quot;&gt;Medical databases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+health%22&quot;&gt;Mental health&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Questionnaires%22&quot;&gt;Questionnaires&lt;/searchLink&gt;
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  Data: &lt;bold&gt;Purpose: &lt;/bold&gt;Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL.&lt;bold&gt;Methods: &lt;/bold&gt;Six hundred ninety-two&#160;patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information). A psychiatrist completed a standardized data collection form encompassing a depression severity scale (MADRS) and clinical information.&lt;bold&gt;Results: &lt;/bold&gt;There was a strong graded association between the severity of depressive symptoms and both the physical (ω 2&#160;=&#160;0.13; p&#160;&lt;&#160;0.01) and mental (ω 2&#160;=&#160;0.34; p&#160;&lt;&#160;0.01) SF-12 domains. Additionally, we observed a strong association between concentration difficulties and all HRQOL outcomes independent of other symptoms of depression and robust to adjustment for possible confounders.&lt;bold&gt;Conclusions: &lt;/bold&gt;Our data corroborate previous findings suggesting that cognitive impairment is a feature of unipolar depressive disorders partially independent of the severity of other symptoms, and may represent a specific target of therapy with a strong impact on patients&#39; functioning and quality of life. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s11136-017-1595-4
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