α-LATROTOXIN AND ITS RECEPTORS: Neurexins and CIRL/Latrophilins.
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| Title: | α-LATROTOXIN AND ITS RECEPTORS: Neurexins and CIRL/Latrophilins. |
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| Authors: | Südhof, Thomas C. |
| Source: | Annual Review of Neuroscience. 2001, Vol. 24 Issue 1, p933-962. 30p. |
| Subjects: | Neurotoxic agents, Toxins, Black widow spider, Venom, Exocytosis |
| Abstract: | α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals. α-Latrotoxin is a large protein toxin (120 kDa) that contains 22 ankyrin repeats. In stimulating exocytosis, α-latrotoxin binds to two distinct families of neuronal cell-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a physiological function in synaptic cell adhesion. Binding of α-latrotoxin to these receptors does not in itself trigger exocytosis but serves to recruit the toxin to the synapse. Receptor-bound α-latrotoxin then inserts into the presynaptic plasma membrane to stimulate exocytosis by two distinct transmitter-specific mechanisms. Exocytosis of classical neurotransmitters (glutamate,GABA, acetylcholine) is induced in a calcium-independent manner by a direct intracellular action of α-latrotoxin, while exocytosis of catecholamines requires extracellular calcium. Elucidation of precisely how α-latrotoxin works is likely to provide major insight into how synaptic vesicle exocytosis is regulated, and how the release machineries of classical and catecholaminergic neurotransmitters differ.. [ABSTRACT FROM AUTHOR] |
| Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 12453286 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: α-LATROTOXIN AND ITS RECEPTORS: Neurexins and CIRL/Latrophilins. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Südhof%2C+Thomas+C%2E%22">Südhof, Thomas C.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annual+Review+of+Neuroscience%22">Annual Review of Neuroscience</searchLink>. 2001, Vol. 24 Issue 1, p933-962. 30p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Neurotoxic+agents%22">Neurotoxic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Toxins%22">Toxins</searchLink><br /><searchLink fieldCode="DE" term="%22Black+widow+spider%22">Black widow spider</searchLink><br /><searchLink fieldCode="DE" term="%22Venom%22">Venom</searchLink><br /><searchLink fieldCode="DE" term="%22Exocytosis%22">Exocytosis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals. α-Latrotoxin is a large protein toxin (120 kDa) that contains 22 ankyrin repeats. In stimulating exocytosis, α-latrotoxin binds to two distinct families of neuronal cell-surface receptors, neurexins and CLs (Cirl/latrophilins), which probably have a physiological function in synaptic cell adhesion. Binding of α-latrotoxin to these receptors does not in itself trigger exocytosis but serves to recruit the toxin to the synapse. Receptor-bound α-latrotoxin then inserts into the presynaptic plasma membrane to stimulate exocytosis by two distinct transmitter-specific mechanisms. Exocytosis of classical neurotransmitters (glutamate,GABA, acetylcholine) is induced in a calcium-independent manner by a direct intracellular action of α-latrotoxin, while exocytosis of catecholamines requires extracellular calcium. Elucidation of precisely how α-latrotoxin works is likely to provide major insight into how synaptic vesicle exocytosis is regulated, and how the release machineries of classical and catecholaminergic neurotransmitters differ.. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1146/annurev.neuro.24.1.933 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 30 StartPage: 933 Subjects: – SubjectFull: Neurotoxic agents Type: general – SubjectFull: Toxins Type: general – SubjectFull: Black widow spider Type: general – SubjectFull: Venom Type: general – SubjectFull: Exocytosis Type: general Titles: – TitleFull: α-LATROTOXIN AND ITS RECEPTORS: Neurexins and CIRL/Latrophilins. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Südhof, Thomas C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: 2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 0147006X Numbering: – Type: volume Value: 24 – Type: issue Value: 1 Titles: – TitleFull: Annual Review of Neuroscience Type: main |
| ResultId | 1 |
