Bibliographic Details
| Title: |
RESISTANCE OF DELAYED-RECTIFIER K+ CURRENT TO CADMIUM IN DROSOPHILA NEURONS. |
| Authors: |
Alshuaib, Waleed B., Mathew, Mini V. |
| Source: |
International Journal of Neuroscience. 2004, Vol. 114 Issue 4, p481-491. 11p. |
| Subjects: |
Cadmium, Neurotoxicology, Potassium, Neurons, Alkali metals, Neurophysiology |
| Abstract: |
The delayed-rectifier potassium current (IKDR)is important in repolarizing the membrane potential and determining the level of neuronal excitability. We investigated the effect of cadmium on this potassium current. The whole-cell patch-clamp technique was used to measure IKDR from cultured Drosophila neurons derived from embryonic neuroblasts. The current was measured from neurons before and after the application of 0.1 mM cadmium to the external saline. IKDR was similar in the cadmium-containing saline(383±47 pA) an the control saline (401±60 pA). These results indicate that cadmium neurotoxicity does not specifically affect IKDR in Drosophila neurons. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
