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An algal photoenzyme converts fatty acids to hydrocarbons.

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Title: An algal photoenzyme converts fatty acids to hydrocarbons.
Authors: Sorigué, Damien, Légeret, Bertrand, Cuiné, Stéphan, Blangy, Stéphanie, Moulin, Solène, Billon, Emmanuelle, Richaud, Pierre, Brugière, Sabine, Couté, Yohann, Nurizzo, Didier, Müller, Pavel, Brettel, Klaus, Pignol, David, Arnoux, Pascal, Li-Beisson, Yonghua, Peltier, Gilles, Beisson, Fred
Source: Science (pre-March 2025). 9/1/2017, Vol. 357 Issue 6354, p903-907. 5p. 3 Color Photographs, 3 Graphs.
Subjects: Algae & the environment, Enzyme inhibitors, Chlorella, Fatty acids, Decarboxylase inhibitors, Hydrocarbons
Abstract: Although many organisms capture or respond to sunlight, few enzymes are known to be driven by light. Among these are DNA photolyases and the photosynthetic reaction centers. Here, we show that the microalga Chlorella variabilis NC64A harbors a photoenzyme that acts in lipid metabolism. This enzyme belongs to an algae-specific clade of the glucose-methanol-choline oxidoreductase family and catalyzes the decarboxylation of free fatty acids to n-alkanes or -alkenes in response to blue light. Crystal structure of the protein reveals a fatty acid–binding site in a hydrophobic tunnel leading to the light-capturing flavin adenine dinucleotide (FAD) cofactor. The decarboxylation is initiated through electron abstraction from the fatty acid by the photoexcited FAD with a quantum yield >80%. This photoenzyme, which we name fatty acid photodecarboxylase, may be useful in light-driven, bio-based production of hydrocarbons. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: An algal photoenzyme converts fatty acids to hydrocarbons.
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  Data: <searchLink fieldCode="AR" term="%22Sorigué%2C+Damien%22">Sorigué, Damien</searchLink><br /><searchLink fieldCode="AR" term="%22Légeret%2C+Bertrand%22">Légeret, Bertrand</searchLink><br /><searchLink fieldCode="AR" term="%22Cuiné%2C+Stéphan%22">Cuiné, Stéphan</searchLink><br /><searchLink fieldCode="AR" term="%22Blangy%2C+Stéphanie%22">Blangy, Stéphanie</searchLink><br /><searchLink fieldCode="AR" term="%22Moulin%2C+Solène%22">Moulin, Solène</searchLink><br /><searchLink fieldCode="AR" term="%22Billon%2C+Emmanuelle%22">Billon, Emmanuelle</searchLink><br /><searchLink fieldCode="AR" term="%22Richaud%2C+Pierre%22">Richaud, Pierre</searchLink><br /><searchLink fieldCode="AR" term="%22Brugière%2C+Sabine%22">Brugière, Sabine</searchLink><br /><searchLink fieldCode="AR" term="%22Couté%2C+Yohann%22">Couté, Yohann</searchLink><br /><searchLink fieldCode="AR" term="%22Nurizzo%2C+Didier%22">Nurizzo, Didier</searchLink><br /><searchLink fieldCode="AR" term="%22Müller%2C+Pavel%22">Müller, Pavel</searchLink><br /><searchLink fieldCode="AR" term="%22Brettel%2C+Klaus%22">Brettel, Klaus</searchLink><br /><searchLink fieldCode="AR" term="%22Pignol%2C+David%22">Pignol, David</searchLink><br /><searchLink fieldCode="AR" term="%22Arnoux%2C+Pascal%22">Arnoux, Pascal</searchLink><br /><searchLink fieldCode="AR" term="%22Li-Beisson%2C+Yonghua%22">Li-Beisson, Yonghua</searchLink><br /><searchLink fieldCode="AR" term="%22Peltier%2C+Gilles%22">Peltier, Gilles</searchLink><br /><searchLink fieldCode="AR" term="%22Beisson%2C+Fred%22">Beisson, Fred</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 9/1/2017, Vol. 357 Issue 6354, p903-907. 5p. 3 Color Photographs, 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Algae+%26+the+environment%22">Algae & the environment</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme+inhibitors%22">Enzyme inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Chlorella%22">Chlorella</searchLink><br /><searchLink fieldCode="DE" term="%22Fatty+acids%22">Fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22Decarboxylase+inhibitors%22">Decarboxylase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrocarbons%22">Hydrocarbons</searchLink>
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  Label: Abstract
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  Data: Although many organisms capture or respond to sunlight, few enzymes are known to be driven by light. Among these are DNA photolyases and the photosynthetic reaction centers. Here, we show that the microalga Chlorella variabilis NC64A harbors a photoenzyme that acts in lipid metabolism. This enzyme belongs to an algae-specific clade of the glucose-methanol-choline oxidoreductase family and catalyzes the decarboxylation of free fatty acids to n-alkanes or -alkenes in response to blue light. Crystal structure of the protein reveals a fatty acid–binding site in a hydrophobic tunnel leading to the light-capturing flavin adenine dinucleotide (FAD) cofactor. The decarboxylation is initiated through electron abstraction from the fatty acid by the photoexcited FAD with a quantum yield >80%. This photoenzyme, which we name fatty acid photodecarboxylase, may be useful in light-driven, bio-based production of hydrocarbons. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=125029800
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        Value: 10.1126/science.aan6349
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 5
        StartPage: 903
    Subjects:
      – SubjectFull: Algae & the environment
        Type: general
      – SubjectFull: Enzyme inhibitors
        Type: general
      – SubjectFull: Chlorella
        Type: general
      – SubjectFull: Fatty acids
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      – SubjectFull: Decarboxylase inhibitors
        Type: general
      – SubjectFull: Hydrocarbons
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      – TitleFull: An algal photoenzyme converts fatty acids to hydrocarbons.
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              Text: 9/1/2017
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