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Ecological impact of ampicillin and cefuroxime in neonatal units.

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Title: Ecological impact of ampicillin and cefuroxime in neonatal units.
Authors: Tullus, K (AUTHOR), Burman, L G (AUTHOR)
Source: Lancet. 6/24/1989, Vol. 333 Issue 8652, p1405-1407. 3p.
Subjects: Carrier state (Communicable diseases), Cefuroxime, Cephalosporins, Comparative studies, Drug resistance in microorganisms, Clinical drug trials, Ecology, Enterobacteriaceae, Escherichia coli, Gram-negative bacteria, Intensive care units, Klebsiella, Research methodology, Medical cooperation, Research, Evaluation research, Ampicillin, Pharmacodynamics
Abstract: The relation between local antibiotic consumption and faecal carriage of beta-lactam-resistant strains of Escherichia coli and Klebsiella spp was studied in 953 children discharged from twenty-two neonatal units. An increased rate of carriers of Klebsiella spp strains resistant to ampicillin, cefuroxime, and cephalexin and of E coli strains resistant to ampicillin was associated with the use of ampicillin, with or without gentamicin. Ampicillin and cephalosporin (86% cefuroxime) consumptions were inversely related, which probably explained the paradox that cephalosporin use (and therefore less ampicillin use) was negatively correlated with the carriage of Klebsiella spp strains resistant to ampicillin, cefuroxime, and cephalexin. The ecological impact of antibiotics was much the same among treated and untreated babies in each unit. The findings show a greater risk of drug resistance due to a related agent rather than to the drug itself and a clear indirect impact of an antibotic on the microflora of untreated patients. Ampicillin-based regimens are more likely than cefuroxime to produce drug-resistant strains in the newborn. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Ecological impact of ampicillin and cefuroxime in neonatal units.
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 6/24/1989, Vol. 333 Issue 8652, p1405-1407. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Carrier+state+%28Communicable+diseases%29%22">Carrier state (Communicable diseases)</searchLink><br /><searchLink fieldCode="DE" term="%22Cefuroxime%22">Cefuroxime</searchLink><br /><searchLink fieldCode="DE" term="%22Cephalosporins%22">Cephalosporins</searchLink><br /><searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance+in+microorganisms%22">Drug resistance in microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+drug+trials%22">Clinical drug trials</searchLink><br /><searchLink fieldCode="DE" term="%22Ecology%22">Ecology</searchLink><br /><searchLink fieldCode="DE" term="%22Enterobacteriaceae%22">Enterobacteriaceae</searchLink><br /><searchLink fieldCode="DE" term="%22Escherichia+coli%22">Escherichia coli</searchLink><br /><searchLink fieldCode="DE" term="%22Gram-negative+bacteria%22">Gram-negative bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Intensive+care+units%22">Intensive care units</searchLink><br /><searchLink fieldCode="DE" term="%22Klebsiella%22">Klebsiella</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Evaluation+research%22">Evaluation research</searchLink><br /><searchLink fieldCode="DE" term="%22Ampicillin%22">Ampicillin</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacodynamics%22">Pharmacodynamics</searchLink>
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  Data: The relation between local antibiotic consumption and faecal carriage of beta-lactam-resistant strains of Escherichia coli and Klebsiella spp was studied in 953 children discharged from twenty-two neonatal units. An increased rate of carriers of Klebsiella spp strains resistant to ampicillin, cefuroxime, and cephalexin and of E coli strains resistant to ampicillin was associated with the use of ampicillin, with or without gentamicin. Ampicillin and cephalosporin (86% cefuroxime) consumptions were inversely related, which probably explained the paradox that cephalosporin use (and therefore less ampicillin use) was negatively correlated with the carriage of Klebsiella spp strains resistant to ampicillin, cefuroxime, and cephalexin. The ecological impact of antibiotics was much the same among treated and untreated babies in each unit. The findings show a greater risk of drug resistance due to a related agent rather than to the drug itself and a clear indirect impact of an antibotic on the microflora of untreated patients. Ampicillin-based regimens are more likely than cefuroxime to produce drug-resistant strains in the newborn. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/s0140-6736(89)90122-0
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 3
        StartPage: 1405
    Subjects:
      – SubjectFull: Carrier state (Communicable diseases)
        Type: general
      – SubjectFull: Cefuroxime
        Type: general
      – SubjectFull: Cephalosporins
        Type: general
      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Drug resistance in microorganisms
        Type: general
      – SubjectFull: Clinical drug trials
        Type: general
      – SubjectFull: Ecology
        Type: general
      – SubjectFull: Enterobacteriaceae
        Type: general
      – SubjectFull: Escherichia coli
        Type: general
      – SubjectFull: Gram-negative bacteria
        Type: general
      – SubjectFull: Intensive care units
        Type: general
      – SubjectFull: Klebsiella
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Evaluation research
        Type: general
      – SubjectFull: Ampicillin
        Type: general
      – SubjectFull: Pharmacodynamics
        Type: general
    Titles:
      – TitleFull: Ecological impact of ampicillin and cefuroxime in neonatal units.
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            NameFull: Burman, L G
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            – D: 24
              M: 06
              Text: 6/24/1989
              Type: published
              Y: 1989
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              Value: 333
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              Value: 8652
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