Quality of life in an Italian cohort of people living with HIV in the era of combined antiretroviral therapy (Evidence from I.A.N.U.A. study-investigation on antiretroviral therapy).
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| Title: | Quality of life in an Italian cohort of people living with HIV in the era of combined antiretroviral therapy (Evidence from I.A.N.U.A. study-investigation on antiretroviral therapy). |
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| Authors: | Venturini, A. (AUTHOR), Cenderello, G. (AUTHOR), Di Biagio, A. (AUTHOR), Giannini, B. (AUTHOR), Ameri, M. (AUTHOR), Giacomini, M. (AUTHOR), Montefiori, M. (AUTHOR), Setti, M. (AUTHOR), Mazzarello, G. (AUTHOR), Merlano, C. (AUTHOR), Orcamo, P. (AUTHOR), Viscoli, C. (AUTHOR), Cassola, G. (AUTHOR) |
| Source: | AIDS Care. Nov2017, Vol. 29 Issue 11, p1373-1377. 5p. |
| Subjects: | Quality of life, Age distribution, Statistical correlation, Hepatitis C, HIV-positive persons, Hospital care, Research methodology, Questionnaires, Statistical sampling, Viral load, Multiple regression analysis, Socioeconomic factors, Highly active antiretroviral therapy, Visual analog scale, Cross-sectional method, Descriptive statistics, CD4 lymphocyte count, Mixed infections |
| Geographic Terms: | Italy |
| Abstract: | The aims of this study were to assess the Health Related Quality of Life (HRQoL) of People Living with HIV/AIDS (PLWHA) who attend outpatient services in Genoa, Italy, and to evaluate the relationship between HRQoL and clinical factors, primarily: CD4+ cell count, viral load and HIV-Hepatitis C Virus (HCV) coinfection. A cross-sectional study was performed involving a sample of 943 consecutive patients. Firstly the EuroQol-Five Dimensions-Three Level (EQ-5D-3L) self-reported questionnaire was used to evaluate HRQoL, while socio-demographic information was collected using a separate self-administered questionnaire. Descriptive statistical analysis was then used to show the socio-demographic and clinical characteristics of the sample. Having characterized the sample, Pearson's correlation technique was used to assess the relationship between HRQoL and socio-demographic and clinical characteristics. Finally, multivariable linear regression was used to determine factors associated with HRQOL. The median EQ-Visual analogue scale (EQ-VAS) score was 75.4 (SD 18.4). We found statistically significant associations between the EQ-VAS score and age, coinfection with HCV+, education, other drugs taken over cART, hospitalization due to HIV and a CD4+ cell count <200 mm³ compared with CD4+ cell count >500 mm³. Factors independently associated with lower HRQoL were: older age, coinfection with HCV+, other drugs used in addition to cART, hospitalization due to HIV and CD4+ cell count <200 mm³ compared with CD4+ cell count >500 mm³. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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