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Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.

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Title: Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.
Authors: Abautret-Daly, Áine (AUTHOR), Dempsey, Elaine (AUTHOR), Riestra, Sabino (AUTHOR), de Francisco-García, Ruth (AUTHOR), Parra-Blanco, Adolfo (AUTHOR), Rodrigo, Luis (AUTHOR), Medina, Carlos (AUTHOR), Connor, Thomas J. (AUTHOR), Harkin, Andrew (AUTHOR)
Source: International Journal of Psychiatry in Clinical Practice. Sep2017, Vol. 21 Issue 3, p221-230. 10p.
Subjects: Biomarkers, Biopsy, C-reactive protein, Mental depression, Gene expression, Inflammatory bowel diseases, Interferons, Interleukins, Questionnaires, Tryptophan, Well-being, Anxiety disorders, Severity of illness index
Abstract: Objective:This study aimed at investigating the associations between inflammatory mediators, symptoms and psychological disturbances in inflammatory bowel disease (IBD) patients. Methods:IBD patients and patient controls were examined during a single visit to a gastroenterology clinic. Disease activity was assessed using the Mayo index for ulcerative colitis (UC), inflammatory bowel disease questionnaire (IBDQ), Crohn’s disease activity index (CDAI) and Crohn’s disease endoscopic index of severity (CDEIS). Gene expression of inflammatory mediators were measured in intestinal biopsies and whole blood samples along with circulating concentrations of interleukin (IL)-6, interferon (IFN)γ, C-reactive protein (CRP), kynurenine and tryptophan. Validated depression, anxiety and quality of life scores were used to assess psychological well-being. Results:Patients who were symptomatic had the highest depression and anxiety scores, together with increased intestinal expression of IL-1β, IL-6 and matrix metalloproteinase-9, increased circulating IL-6 and CRP, and an increased circulating kynurenine:tryptophan ratio. Increased Hamilton depression (HAM-D) scores in IBD patients were observed independent of the psychological impact of acute symptoms. Conclusions:Active IBD is associated with symptoms of depression and anxiety and with a raised circulating inflammatory mediator profile. Patients with active IBD exhibiting psychological symptoms should undergo psychological evaluation to ensure the psychological aspects of the condition are considered and addressed. [ABSTRACT FROM PUBLISHER]
Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease.
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  Data: <searchLink fieldCode="AR" term="%22Abautret-Daly%2C+Áine%22">Abautret-Daly, Áine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dempsey%2C+Elaine%22">Dempsey, Elaine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riestra%2C+Sabino%22">Riestra, Sabino</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Francisco-García%2C+Ruth%22">de Francisco-García, Ruth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parra-Blanco%2C+Adolfo%22">Parra-Blanco, Adolfo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodrigo%2C+Luis%22">Rodrigo, Luis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Medina%2C+Carlos%22">Medina, Carlos</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Connor%2C+Thomas+J%2E%22">Connor, Thomas J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Harkin%2C+Andrew%22">Harkin, Andrew</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Psychiatry+in+Clinical+Practice%22">International Journal of Psychiatry in Clinical Practice</searchLink>. Sep2017, Vol. 21 Issue 3, p221-230. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Biopsy%22">Biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22C-reactive+protein%22">C-reactive protein</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammatory+bowel+diseases%22">Inflammatory bowel diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Interferons%22">Interferons</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukins%22">Interleukins</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Tryptophan%22">Tryptophan</searchLink><br /><searchLink fieldCode="DE" term="%22Well-being%22">Well-being</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Severity+of+illness+index%22">Severity of illness index</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective:This study aimed at investigating the associations between inflammatory mediators, symptoms and psychological disturbances in inflammatory bowel disease (IBD) patients. Methods:IBD patients and patient controls were examined during a single visit to a gastroenterology clinic. Disease activity was assessed using the Mayo index for ulcerative colitis (UC), inflammatory bowel disease questionnaire (IBDQ), Crohn’s disease activity index (CDAI) and Crohn’s disease endoscopic index of severity (CDEIS). Gene expression of inflammatory mediators were measured in intestinal biopsies and whole blood samples along with circulating concentrations of interleukin (IL)-6, interferon (IFN)γ, C-reactive protein (CRP), kynurenine and tryptophan. Validated depression, anxiety and quality of life scores were used to assess psychological well-being. Results:Patients who were symptomatic had the highest depression and anxiety scores, together with increased intestinal expression of IL-1β, IL-6 and matrix metalloproteinase-9, increased circulating IL-6 and CRP, and an increased circulating kynurenine:tryptophan ratio. Increased Hamilton depression (HAM-D) scores in IBD patients were observed independent of the psychological impact of acute symptoms. Conclusions:Active IBD is associated with symptoms of depression and anxiety and with a raised circulating inflammatory mediator profile. Patients with active IBD exhibiting psychological symptoms should undergo psychological evaluation to ensure the psychological aspects of the condition are considered and addressed. [ABSTRACT FROM PUBLISHER]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Psychiatry in Clinical Practice is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=125435106
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        Value: 10.1080/13651501.2017.1306081
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        Text: English
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        PageCount: 10
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      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Biopsy
        Type: general
      – SubjectFull: C-reactive protein
        Type: general
      – SubjectFull: Mental depression
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      – SubjectFull: Gene expression
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      – SubjectFull: Inflammatory bowel diseases
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      – SubjectFull: Interferons
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      – SubjectFull: Tryptophan
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      – SubjectFull: Severity of illness index
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              Text: Sep2017
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