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Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts.

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Title: Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts.
Authors: Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J., Fall, C.H.D.
Source: Acta Physiologica Scandinavica. Apr2004, Vol. 180 Issue 4, p359-366. 8p.
Subjects: Somatomedin, Middle age, Birth weight, Osteoporosis, Cardiovascular diseases, Somatotropin
Geographic Terms: United Kingdom
Abstract: Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings. To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy. Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston ( n = 254, born 1935–1943) and Sheffield ( n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded. Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year. In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica+Scandinavica%22">Acta Physiologica Scandinavica</searchLink>. Apr2004, Vol. 180 Issue 4, p359-366. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Somatomedin%22">Somatomedin</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+age%22">Middle age</searchLink><br /><searchLink fieldCode="DE" term="%22Birth+weight%22">Birth weight</searchLink><br /><searchLink fieldCode="DE" term="%22Osteoporosis%22">Osteoporosis</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases%22">Cardiovascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Somatotropin%22">Somatotropin</searchLink>
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  Data: Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings. To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy. Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston ( n = 254, born 1935–1943) and Sheffield ( n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded. Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year. In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Physiologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Apr2004
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