Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts.
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| Title: | Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts. |
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| Authors: | Holt, R.I.G., Syddall, H.E., Phillips, D.I.W., Martyn, C.N., Gluckman, P.D., Breier, B.H., Wood, P.J., Fall, C.H.D. |
| Source: | Acta Physiologica Scandinavica. Apr2004, Vol. 180 Issue 4, p359-366. 8p. |
| Subjects: | Somatomedin, Middle age, Birth weight, Osteoporosis, Cardiovascular diseases, Somatotropin |
| Geographic Terms: | United Kingdom |
| Abstract: | Small body size at birth and during infancy is associated with an increased risk of adult osteoporosis and cardiovascular disease. Fetal programming of the growth hormone–insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings. To determine whether measurements of GH and IGF-I in late middle age were related to size at birth and in infancy. Overnight urinary GH excretion and fasting serum IGF-I were measured in 309 men and 193 women from Hertfordshire (born 1920–1930) for whom birthweight and weight at 1 year were recorded. Serum IGF-I was measured in men and women from Preston ( n = 254, born 1935–1943) and Sheffield ( n = 215, born 1939–1940) whose birthweight and other birth measurements were recorded. Urinary GH and serum IGF-I were not related to birthweight, other measurements at birth, or weight at 1 year. In contrast to previous studies in children or young adults, these data do not support the hypothesis that IGF-I concentrations are programmed by intra-uterine events, as assessed by birthweight, in late middle age. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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