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Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD.

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Title: Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD.
Authors: Mehta, D., Bruenig, D., Carrillo ‐ Roa, T., Lawford, B., Harvey, W., Morris, C. P., Smith, A. K., Binder, E. B., Young, R. McD, Voisey, J.
Source: Acta Psychiatrica Scandinavica. Nov2017, Vol. 136 Issue 5, p493-505. 13p. 4 Charts, 2 Graphs.
Subjects: DNA methylation, Post-traumatic stress disorder, Regression analysis, Neuropsychiatry, Biomarkers
Abstract: Objective Epigenetic modifications such as DNA methylation may play a key role in the aetiology and serve as biomarkers for post-traumatic stress disorder ( PTSD). We performed a genomewide analysis to identify genes whose DNA methylation levels are associated with PTSD. Method A total of 211 individuals comprising Australian male Vietnam War veterans ( n = 96) and males from a general population belonging to the Grady Trauma Project ( n = 115) were included. Genomewide DNA methylation was performed from peripheral blood using the Illumina arrays. Data analysis was performed using generalized linear regression models. Results Differential DNA methylation of 17 previously reported PTSD candidate genes was associated with PTSD symptom severity. Genomewide analyses revealed CpG sites spanning BRSK1, LCN8, NFG and DOCK2 genes were associated with PTSD symptom severity. We replicated the findings of DOCK2 in an independent cohort. Pathway analysis revealed that among the associated genes, genes within actin cytoskeleton and focal adhesion molecular pathways were enriched. Conclusion These data highlight the role of DNA methylation as biomarkers of PTSD. The results support the role of previous candidates and uncover novel genes associated with PTSD, such as DOCK2. This study contributes to our understanding of the biological underpinnings of PTSD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD.
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  Data: <searchLink fieldCode="AR" term="%22Mehta%2C+D%2E%22">Mehta, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Bruenig%2C+D%2E%22">Bruenig, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Carrillo+‐+Roa%2C+T%2E%22">Carrillo ‐ Roa, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Lawford%2C+B%2E%22">Lawford, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Harvey%2C+W%2E%22">Harvey, W.</searchLink><br /><searchLink fieldCode="AR" term="%22Morris%2C+C%2E+P%2E%22">Morris, C. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+A%2E+K%2E%22">Smith, A. K.</searchLink><br /><searchLink fieldCode="AR" term="%22Binder%2C+E%2E+B%2E%22">Binder, E. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Young%2C+R%2E+McD%22">Young, R. McD</searchLink><br /><searchLink fieldCode="AR" term="%22Voisey%2C+J%2E%22">Voisey, J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Nov2017, Vol. 136 Issue 5, p493-505. 13p. 4 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22DNA+methylation%22">DNA methylation</searchLink><br /><searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychiatry%22">Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink>
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  Data: Objective Epigenetic modifications such as DNA methylation may play a key role in the aetiology and serve as biomarkers for post-traumatic stress disorder ( PTSD). We performed a genomewide analysis to identify genes whose DNA methylation levels are associated with PTSD. Method A total of 211 individuals comprising Australian male Vietnam War veterans ( n = 96) and males from a general population belonging to the Grady Trauma Project ( n = 115) were included. Genomewide DNA methylation was performed from peripheral blood using the Illumina arrays. Data analysis was performed using generalized linear regression models. Results Differential DNA methylation of 17 previously reported PTSD candidate genes was associated with PTSD symptom severity. Genomewide analyses revealed CpG sites spanning BRSK1, LCN8, NFG and DOCK2 genes were associated with PTSD symptom severity. We replicated the findings of DOCK2 in an independent cohort. Pathway analysis revealed that among the associated genes, genes within actin cytoskeleton and focal adhesion molecular pathways were enriched. Conclusion These data highlight the role of DNA methylation as biomarkers of PTSD. The results support the role of previous candidates and uncover novel genes associated with PTSD, such as DOCK2. This study contributes to our understanding of the biological underpinnings of PTSD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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