Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development.
Saved in:
| Title: | Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development. |
|---|---|
| Authors: | Wiggins, Lisa, Tian, Lin, Levy, Susan, Rice, Catherine, Lee, Li-Ching, Schieve, Laura, Pandey, Juhi, Daniels, Julie, Blaskey, Lisa, Hepburn, Susan, Landa, Rebecca, Edmondson-Pretzel, Rebecca, Thompson, William |
| Source: | Journal of Autism & Developmental Disorders. Nov2017, Vol. 47 Issue 11, p3634-3645. 12p. |
| Subjects: | Algorithms, Autism in children, Child development, Diagnosis, Medical screening, Phenotypes |
| Abstract: | The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 125560191 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Wiggins%2C+Lisa%22">Wiggins, Lisa</searchLink><br /><searchLink fieldCode="AR" term="%22Tian%2C+Lin%22">Tian, Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Levy%2C+Susan%22">Levy, Susan</searchLink><br /><searchLink fieldCode="AR" term="%22Rice%2C+Catherine%22">Rice, Catherine</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Li-Ching%22">Lee, Li-Ching</searchLink><br /><searchLink fieldCode="AR" term="%22Schieve%2C+Laura%22">Schieve, Laura</searchLink><br /><searchLink fieldCode="AR" term="%22Pandey%2C+Juhi%22">Pandey, Juhi</searchLink><br /><searchLink fieldCode="AR" term="%22Daniels%2C+Julie%22">Daniels, Julie</searchLink><br /><searchLink fieldCode="AR" term="%22Blaskey%2C+Lisa%22">Blaskey, Lisa</searchLink><br /><searchLink fieldCode="AR" term="%22Hepburn%2C+Susan%22">Hepburn, Susan</searchLink><br /><searchLink fieldCode="AR" term="%22Landa%2C+Rebecca%22">Landa, Rebecca</searchLink><br /><searchLink fieldCode="AR" term="%22Edmondson-Pretzel%2C+Rebecca%22">Edmondson-Pretzel, Rebecca</searchLink><br /><searchLink fieldCode="AR" term="%22Thompson%2C+William%22">Thompson, William</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Nov2017, Vol. 47 Issue 11, p3634-3645. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Algorithms%22">Algorithms</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+in+children%22">Autism in children</searchLink><br /><searchLink fieldCode="DE" term="%22Child+development%22">Child development</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnosis%22">Diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+screening%22">Medical screening</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=125560191 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10803-017-3280-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 3634 Subjects: – SubjectFull: Algorithms Type: general – SubjectFull: Autism in children Type: general – SubjectFull: Child development Type: general – SubjectFull: Diagnosis Type: general – SubjectFull: Medical screening Type: general – SubjectFull: Phenotypes Type: general Titles: – TitleFull: Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wiggins, Lisa – PersonEntity: Name: NameFull: Tian, Lin – PersonEntity: Name: NameFull: Levy, Susan – PersonEntity: Name: NameFull: Rice, Catherine – PersonEntity: Name: NameFull: Lee, Li-Ching – PersonEntity: Name: NameFull: Schieve, Laura – PersonEntity: Name: NameFull: Pandey, Juhi – PersonEntity: Name: NameFull: Daniels, Julie – PersonEntity: Name: NameFull: Blaskey, Lisa – PersonEntity: Name: NameFull: Hepburn, Susan – PersonEntity: Name: NameFull: Landa, Rebecca – PersonEntity: Name: NameFull: Edmondson-Pretzel, Rebecca – PersonEntity: Name: NameFull: Thompson, William IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 01623257 Numbering: – Type: volume Value: 47 – Type: issue Value: 11 Titles: – TitleFull: Journal of Autism & Developmental Disorders Type: main |
| ResultId | 1 |
