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PKC-A DIFFERENTIALLY AFFECTS RUTABAGA AND WILD-TYPE DROSOPHILA NEURONAL POTASSIUM CURRENT.

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Title: PKC-A DIFFERENTIALLY AFFECTS RUTABAGA AND WILD-TYPE DROSOPHILA NEURONAL POTASSIUM CURRENT.
Authors: Alshuaib, Waleed B., Mathew, Mini V., Hasan, Mohammed Y., Fahim, Mohamed A.
Source: International Journal of Neuroscience. 2004, Vol. 114 Issue 5, p607-621. 15p.
Subjects: Drosophila, Genetic mutation, Learning, Memory, Plasminogen activators, Protein kinase C, Neurons
Abstract: Learning and memory are defective in the Drosophila mutant rutabaga, which has a low intracellular cyclic adenosine monophosphate (cAMP) concentration. The aim of this study was to compare modulation effects of protein kinase C activator (PKC-A) on the delayed-rectifier potassium current (IKDR) in wild-type and rutabaga neurons. IKDR was measured from cultured (2 days) wild-type and rutabaga neurons. The authors examined the effects of PKC-A on IKDR in wild-type and rutabaga neurons. IKDR was measured from neurons before and after addition of PKC-A to the external solution. IKDR was smaller in rutabaga neurons (380 ± 25 pA) than in wild-type neurons (529 ± 44 pA). IKDR was reduced by PKC-A more in wild-type (↓55 ± 6%) than in rutabaga (↓35 ± 8%) neurons (single-cell studies). In the presence of PKC-A, there was no difference in IKDR between wild-type (229 ± 31 pA) and rutabaga (242 ± 26 pA) neurons (population studies). These results indicate that PKC-A differentially affects the delayed-rectifier channel in wild-type and rutabaga. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: PKC-A DIFFERENTIALLY AFFECTS RUTABAGA AND WILD-TYPE DROSOPHILA NEURONAL POTASSIUM CURRENT.
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  Data: <searchLink fieldCode="AR" term="%22Alshuaib%2C+Waleed+B%2E%22">Alshuaib, Waleed B.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathew%2C+Mini+V%2E%22">Mathew, Mini V.</searchLink><br /><searchLink fieldCode="AR" term="%22Hasan%2C+Mohammed+Y%2E%22">Hasan, Mohammed Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Fahim%2C+Mohamed+A%2E%22">Fahim, Mohamed A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. 2004, Vol. 114 Issue 5, p607-621. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Drosophila%22">Drosophila</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+mutation%22">Genetic mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Learning%22">Learning</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Plasminogen+activators%22">Plasminogen activators</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinase+C%22">Protein kinase C</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink>
– Name: Abstract
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  Data: Learning and memory are defective in the Drosophila mutant rutabaga, which has a low intracellular cyclic adenosine monophosphate (cAMP) concentration. The aim of this study was to compare modulation effects of protein kinase C activator (PKC-A) on the delayed-rectifier potassium current (IKDR) in wild-type and rutabaga neurons. IKDR was measured from cultured (2 days) wild-type and rutabaga neurons. The authors examined the effects of PKC-A on IKDR in wild-type and rutabaga neurons. IKDR was measured from neurons before and after addition of PKC-A to the external solution. IKDR was smaller in rutabaga neurons (380 ± 25 pA) than in wild-type neurons (529 ± 44 pA). IKDR was reduced by PKC-A more in wild-type (↓55 ± 6%) than in rutabaga (↓35 ± 8%) neurons (single-cell studies). In the presence of PKC-A, there was no difference in IKDR between wild-type (229 ± 31 pA) and rutabaga (242 ± 26 pA) neurons (population studies). These results indicate that PKC-A differentially affects the delayed-rectifier channel in wild-type and rutabaga. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00207450490430480
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        Text: English
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        PageCount: 15
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      – SubjectFull: Drosophila
        Type: general
      – SubjectFull: Genetic mutation
        Type: general
      – SubjectFull: Learning
        Type: general
      – SubjectFull: Memory
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      – SubjectFull: Plasminogen activators
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      – SubjectFull: Protein kinase C
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      – SubjectFull: Neurons
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      – TitleFull: PKC-A DIFFERENTIALLY AFFECTS RUTABAGA AND WILD-TYPE DROSOPHILA NEURONAL POTASSIUM CURRENT.
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            NameFull: Alshuaib, Waleed B.
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            NameFull: Mathew, Mini V.
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            NameFull: Hasan, Mohammed Y.
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              Text: 2004
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              Y: 2004
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