BLOCKING EFFECT OF LANTHANUM ON DELAYED-RECTIFIER K+ CURRENT IN DROSOPHILA NEURONS.
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| Title: | BLOCKING EFFECT OF LANTHANUM ON DELAYED-RECTIFIER K+ CURRENT IN DROSOPHILA NEURONS. |
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| Authors: | Alshuaib, Waleed B., Mathew, Mini V. |
| Source: | International Journal of Neuroscience. 2004, Vol. 114 Issue 5, p639-650. 12p. |
| Subjects: | Lanthanum, Potassium, Neurons, Excitable membranes, Drosophila, Neurotoxicology |
| Abstract: | The delayed-rectifier potassium current (IKDR) is important in regulating neuronal excitability. The authors characterized the neurotoxic effect of lanthanum on IKDR. The conventional whole-cell patch-clamp technique was applied to cultured Drosphila neurons derived from embryonic neuroblasts. IKDR was measured from neurons before and after application of 0.1 mM lanthanum to the external saline. IKDR was smaller in the lanthanum-containing saline (441 ± 57 pA) than in the control saline (680 ± 35 pA) (p < .001). Activation and inactivation of IKDR were unchanged by lanthanum. Because these results suggest that lanthanum acts as a potent blocker of IKDR, neuronal excitability may be altered during lanthanum neurotoxicity. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 12583988 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: BLOCKING EFFECT OF LANTHANUM ON DELAYED-RECTIFIER K+ CURRENT IN DROSOPHILA NEURONS. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Alshuaib%2C+Waleed+B%2E%22">Alshuaib, Waleed B.</searchLink><br /><searchLink fieldCode="AR" term="%22Mathew%2C+Mini+V%2E%22">Mathew, Mini V.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. 2004, Vol. 114 Issue 5, p639-650. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Lanthanum%22">Lanthanum</searchLink><br /><searchLink fieldCode="DE" term="%22Potassium%22">Potassium</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Excitable+membranes%22">Excitable membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Drosophila%22">Drosophila</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotoxicology%22">Neurotoxicology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The delayed-rectifier potassium current (IKDR) is important in regulating neuronal excitability. The authors characterized the neurotoxic effect of lanthanum on IKDR. The conventional whole-cell patch-clamp technique was applied to cultured Drosphila neurons derived from embryonic neuroblasts. IKDR was measured from neurons before and after application of 0.1 mM lanthanum to the external saline. IKDR was smaller in the lanthanum-containing saline (441 ± 57 pA) than in the control saline (680 ± 35 pA) (p < .001). Activation and inactivation of IKDR were unchanged by lanthanum. Because these results suggest that lanthanum acts as a potent blocker of IKDR, neuronal excitability may be altered during lanthanum neurotoxicity. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=12583988 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207450490430507 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 639 Subjects: – SubjectFull: Lanthanum Type: general – SubjectFull: Potassium Type: general – SubjectFull: Neurons Type: general – SubjectFull: Excitable membranes Type: general – SubjectFull: Drosophila Type: general – SubjectFull: Neurotoxicology Type: general Titles: – TitleFull: BLOCKING EFFECT OF LANTHANUM ON DELAYED-RECTIFIER K+ CURRENT IN DROSOPHILA NEURONS. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alshuaib, Waleed B. – PersonEntity: Name: NameFull: Mathew, Mini V. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 114 – Type: issue Value: 5 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
