Brain functional connectome abnormalities in amyotrophic lateral sclerosis are associated with disability and cortical hyperexcitability.
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| Title: | Brain functional connectome abnormalities in amyotrophic lateral sclerosis are associated with disability and cortical hyperexcitability. |
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| Authors: | Geevasinga, N., Korgaonkar, M. S., Menon, P., Van den Bos, M., Gomes, L., Foster, S., Kiernan, M. C., Vucic, S. |
| Source: | European Journal of Neurology. Dec2017, Vol. 24 Issue 12, p1507-1517. 11p. |
| Subjects: | Brain mapping, Amyotrophic lateral sclerosis, Functional magnetic resonance imaging, Magnetic resonance imaging of the brain, Echo-planar imaging |
| Abstract: | Background and purpose The present study utilized a multimodal approach encompassing connectome networks combined with brain volume analysis, and assessment of cortical excitability to provide novel insights into amyotrophic lateral sclerosis ( ALS) pathogenesis. Methods Magnetic resonance images were acquired using a 3.0-Tesla Signa HDx scanner (GE Healthcare, Milwaukee, WI, USA), using an eight-channel head coil. Magnetic resonance images for the resting-state scan were acquired using an echo-planar imaging magnetic resonance sequence, acquiring 40 contiguous axial/oblique slices. Structural magnetic resonance imaging three-dimensional T1-weighted images were acquired in the sagittal plane using three-dimensional spoiled gradient echo sequences. For structural imaging, a T1-weighted high-resolution (3.0-Tesla) magnetic resonance imaging scan was used. Cortical excitability was assessed by using the threshold-tracking transcranial magnetic stimulation paradigm. Network-based statistics and whole-brain functional topology (using graph theoretical approaches) assessed functional connectivity. Results Using a global network-based statistical analysis approach, functional connectivity was increased in 12 network edges connecting 14 nodes ( P < 0.05) within the frontal, temporal, parietal and subcortical regions. Analysis of local connectedness disclosed dichotomous effects with reduced connectivity in frontal regions and increased connectivity in occipital regions in ALS. Cortical hyperexcitability was evident in patients with ALS, negatively correlated with functional connectivity changes in the pre-central gyrus ( P < 0.01). Connectivity changes in the frontal regions were negatively associated with functional disability ( P < 0.05). Conclusions Multimodal assessment of cortical function in patients with ALS identified deficits in functional connectivity associated with cortical hyperexcitability that correlated with patient disability. Novel integration of functional brain assessment further contributes to the understanding of disease pathogenesis in ALS. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 126261290 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Brain functional connectome abnormalities in amyotrophic lateral sclerosis are associated with disability and cortical hyperexcitability. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Geevasinga%2C+N%2E%22">Geevasinga, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Korgaonkar%2C+M%2E+S%2E%22">Korgaonkar, M. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Menon%2C+P%2E%22">Menon, P.</searchLink><br /><searchLink fieldCode="AR" term="%22Van+den+Bos%2C+M%2E%22">Van den Bos, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Gomes%2C+L%2E%22">Gomes, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Foster%2C+S%2E%22">Foster, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Kiernan%2C+M%2E+C%2E%22">Kiernan, M. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Vucic%2C+S%2E%22">Vucic, S.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Dec2017, Vol. 24 Issue 12, p1507-1517. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Brain+mapping%22">Brain mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Amyotrophic+lateral+sclerosis%22">Amyotrophic lateral sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging+of+the+brain%22">Magnetic resonance imaging of the brain</searchLink><br /><searchLink fieldCode="DE" term="%22Echo-planar+imaging%22">Echo-planar imaging</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background and purpose The present study utilized a multimodal approach encompassing connectome networks combined with brain volume analysis, and assessment of cortical excitability to provide novel insights into amyotrophic lateral sclerosis ( ALS) pathogenesis. Methods Magnetic resonance images were acquired using a 3.0-Tesla Signa HDx scanner (GE Healthcare, Milwaukee, WI, USA), using an eight-channel head coil. Magnetic resonance images for the resting-state scan were acquired using an echo-planar imaging magnetic resonance sequence, acquiring 40 contiguous axial/oblique slices. Structural magnetic resonance imaging three-dimensional T1-weighted images were acquired in the sagittal plane using three-dimensional spoiled gradient echo sequences. For structural imaging, a T1-weighted high-resolution (3.0-Tesla) magnetic resonance imaging scan was used. Cortical excitability was assessed by using the threshold-tracking transcranial magnetic stimulation paradigm. Network-based statistics and whole-brain functional topology (using graph theoretical approaches) assessed functional connectivity. Results Using a global network-based statistical analysis approach, functional connectivity was increased in 12 network edges connecting 14 nodes ( P < 0.05) within the frontal, temporal, parietal and subcortical regions. Analysis of local connectedness disclosed dichotomous effects with reduced connectivity in frontal regions and increased connectivity in occipital regions in ALS. Cortical hyperexcitability was evident in patients with ALS, negatively correlated with functional connectivity changes in the pre-central gyrus ( P < 0.01). Connectivity changes in the frontal regions were negatively associated with functional disability ( P < 0.05). Conclusions Multimodal assessment of cortical function in patients with ALS identified deficits in functional connectivity associated with cortical hyperexcitability that correlated with patient disability. Novel integration of functional brain assessment further contributes to the understanding of disease pathogenesis in ALS. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ene.13461 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 1507 Subjects: – SubjectFull: Brain mapping Type: general – SubjectFull: Amyotrophic lateral sclerosis Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Magnetic resonance imaging of the brain Type: general – SubjectFull: Echo-planar imaging Type: general Titles: – TitleFull: Brain functional connectome abnormalities in amyotrophic lateral sclerosis are associated with disability and cortical hyperexcitability. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Geevasinga, N. – PersonEntity: Name: NameFull: Korgaonkar, M. S. – PersonEntity: Name: NameFull: Menon, P. – PersonEntity: Name: NameFull: Van den Bos, M. – PersonEntity: Name: NameFull: Gomes, L. – PersonEntity: Name: NameFull: Foster, S. – PersonEntity: Name: NameFull: Kiernan, M. C. – PersonEntity: Name: NameFull: Vucic, S. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 13515101 Numbering: – Type: volume Value: 24 – Type: issue Value: 12 Titles: – TitleFull: European Journal of Neurology Type: main |
| ResultId | 1 |
