Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders.
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| Title: | Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. |
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| Authors: | Iwamoto, K., Kakiuchi, C., Bundo, M., Ikeda, K., Kato, T. |
| Source: | Molecular Psychiatry. Apr2004, Vol. 9 Issue 4, p406-416. 11p. |
| Subjects: | Mental depression, Affective disorders, Schizophrenia, Psychoses, Schizotypal personality disorder, Pathological physiology |
| Abstract: | We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. Notably, most of the altered gene expressions in each disease were not shared by one another, suggesting the molecular distinctiveness of these mental disorders. We found a tendency of downregulation of the genes encoding receptor, channels or transporters, and upregulation of the genes encoding stress response proteins or molecular chaperons in bipolar disorder. Altered expressions in bipolar disorder shared by other mental disorders mainly consisted of upregulation of the genes encoding proteins for transcription or translation. The genes identified in this study would be useful for the understanding of the pathophysiology of bipolar disorder, as well as the common pathophysiological background in major mental disorders at the molecular level. In addition, we found the altered expression of LIM and HSPF1 both in the brains and lymphoblastoid cells in bipolar disorder. These genes may have pathophysiological importance and would be novel candidate genes for bipolar disorder.Molecular Psychiatry (2004) 9, 406-416. doi:10.1038/sj.mp.4001437 Published online 26 January 2004 [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 12643653 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Iwamoto%2C+K%2E%22">Iwamoto, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Kakiuchi%2C+C%2E%22">Kakiuchi, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Bundo%2C+M%2E%22">Bundo, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Ikeda%2C+K%2E%22">Ikeda, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Kato%2C+T%2E%22">Kato, T.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Apr2004, Vol. 9 Issue 4, p406-416. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Affective+disorders%22">Affective disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Schizotypal+personality+disorder%22">Schizotypal personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+physiology%22">Pathological physiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. Notably, most of the altered gene expressions in each disease were not shared by one another, suggesting the molecular distinctiveness of these mental disorders. We found a tendency of downregulation of the genes encoding receptor, channels or transporters, and upregulation of the genes encoding stress response proteins or molecular chaperons in bipolar disorder. Altered expressions in bipolar disorder shared by other mental disorders mainly consisted of upregulation of the genes encoding proteins for transcription or translation. The genes identified in this study would be useful for the understanding of the pathophysiology of bipolar disorder, as well as the common pathophysiological background in major mental disorders at the molecular level. In addition, we found the altered expression of LIM and HSPF1 both in the brains and lymphoblastoid cells in bipolar disorder. These genes may have pathophysiological importance and would be novel candidate genes for bipolar disorder.Molecular Psychiatry (2004) 9, 406-416. doi:10.1038/sj.mp.4001437 Published online 26 January 2004 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/sj.mp.4001437 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 406 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Affective disorders Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Psychoses Type: general – SubjectFull: Schizotypal personality disorder Type: general – SubjectFull: Pathological physiology Type: general Titles: – TitleFull: Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Iwamoto, K. – PersonEntity: Name: NameFull: Kakiuchi, C. – PersonEntity: Name: NameFull: Bundo, M. – PersonEntity: Name: NameFull: Ikeda, K. – PersonEntity: Name: NameFull: Kato, T. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 9 – Type: issue Value: 4 Titles: – TitleFull: Molecular Psychiatry Type: main |
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