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High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers.

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Title: High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers.
Authors: Zobel, A. (AUTHOR), Barkow, K. (AUTHOR), Schulze‐Rauschenbach, S. (AUTHOR), Von Widdern, O. (AUTHOR), Metten, M. (AUTHOR), Pfeiffer, U. (AUTHOR), Schnell, S. (AUTHOR), Wagner, M. (AUTHOR), Maier, W. (AUTHOR)
Source: Acta Psychiatrica Scandinavica. May2004, Vol. 109 Issue 5, p392-399. 8p.
Subjects: Volunteers, Temperament, Personality, Corticotropin releasing hormone, Affective disorders, Mental depression
Abstract: Zobel A, Barkow K, Schulze-Rauschenbach S, von Widdern O, Metten M, Pfeiffer U, Schnell S, Wagner M, Maier W. High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers. Acta Psychiatr Scand 2004: 109: 392–399. © Blackwell Munksgaard 2004. Elevated neuroticism, depressive temperament and dysfunctional regulation of the hypothalamic–pituitary–adrenocortical (HPA) system are considered as risk factors for unipolar depression. An interaction of these vulnerability factors was suggested, but controversially discussed. In absence of other informative studies we set out for a replication test and for elucidation of the underlying mechanism. Ninety-two subjects recruited in the community-performed assessments of personality and temperament as well as measurement of HPA function with the dexamethasone/corticotropin-releasing hormone (Dex/CRH) test. Cortisol levels subsequent to Dex/CRH challenge were associated with neuroticism; high-neuroticism subjects revealed a higher HPA activation. This difference was mainly because of male subjects ≥25 years. A similar relationship was observed for depressive temperament. This constellation may propose that HPA dysregulation is the endocrinological basis for neuroticism and depressive temperament; this result supports the view that distinct personality factors and HPA vulnerability interact in mediating depression. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. May2004, Vol. 109 Issue 5, p392-399. 8p.
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  Data: Zobel A, Barkow K, Schulze-Rauschenbach S, von Widdern O, Metten M, Pfeiffer U, Schnell S, Wagner M, Maier W. High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic–pituitary–adrenocortical system in healthy volunteers. Acta Psychiatr Scand 2004: 109: 392–399. © Blackwell Munksgaard 2004. Elevated neuroticism, depressive temperament and dysfunctional regulation of the hypothalamic–pituitary–adrenocortical (HPA) system are considered as risk factors for unipolar depression. An interaction of these vulnerability factors was suggested, but controversially discussed. In absence of other informative studies we set out for a replication test and for elucidation of the underlying mechanism. Ninety-two subjects recruited in the community-performed assessments of personality and temperament as well as measurement of HPA function with the dexamethasone/corticotropin-releasing hormone (Dex/CRH) test. Cortisol levels subsequent to Dex/CRH challenge were associated with neuroticism; high-neuroticism subjects revealed a higher HPA activation. This difference was mainly because of male subjects ≥25 years. A similar relationship was observed for depressive temperament. This constellation may propose that HPA dysregulation is the endocrinological basis for neuroticism and depressive temperament; this result supports the view that distinct personality factors and HPA vulnerability interact in mediating depression. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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