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Muscle fatigability and depressive symptoms in later life.

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Title: Muscle fatigability and depressive symptoms in later life.
Authors: Brown, Patrick J., Badreddine, Dala, Roose, Steven P., Rutherford, Bret, Ayonayon, Hilsa N., Yaffe, Kristine, Simonsick, Eleanor M., Goodpaster, Bret, Health ABC Study (CORPORATE AUTHOR)
Source: International Journal of Geriatric Psychiatry. Dec2017, Vol. 32 Issue 12, pe166-e172. 9p.
Subjects: Muscle fatigue, Mental depression, Old age, Fatigue (Physiology), Aging, Psychological aspects of aging, Skeletal muscle physiology, Cross-sectional method, Proportional hazards models
Abstract: Objective: Fatigability is the degree to which performance decreases during a specific activity of a given intensity and duration. Depression is known to heighten subjective fatigue, but whether its association with physical fatigability is unknown. Further, whether fatigability is a precursor or risk factor for the development of subsequent depressive symptoms is also unclear.Methods: Data are from the Health Aging and Body Composition Study with fatigability assessed using isokinetic dynamometry of the knee extensors at year 3, and depressive symptoms ascertained longitudinally using the Center for Epidemiologic Studies Depression (CES-D) scale. The relationship between fatigability and depressive symptoms was evaluated using linear and Cox regression models.Results: There was a significant cross-sectional association between fatigability and depressive symptomatology (β = -0.06, p = 0.02), after adjusting for demographic variables, medical comorbidities, cognition, gait speed, and physical activity levels. Greater fatigability was associated with greater adjusted scores on the 10-item CES-D (F2, 1695  = 38.65, p < 0.001), with individuals with greater fatigability on average reporting an adjusted CES-D score 0.5 point greater than those individuals with higher levels of resistance to fatigability (mean of 70% or better; p < 0.001). Fatigability however was not associated with the development of depression at follow-up (p = 0.828).Conclusions: This study found an association between skeletal muscle fatigability and higher depressive symptoms in older adults, but no longitudinal association was identified. These findings suggest that age-related changes in energy capacity may affect the phenomenology of late life depression. Copyright © 2017 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Muscle fatigability and depressive symptoms in later life.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brown%2C+Patrick+J%2E%22&quot;&gt;Brown, Patrick J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Badreddine%2C+Dala%22&quot;&gt;Badreddine, Dala&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Roose%2C+Steven+P%2E%22&quot;&gt;Roose, Steven P.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rutherford%2C+Bret%22&quot;&gt;Rutherford, Bret&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ayonayon%2C+Hilsa+N%2E%22&quot;&gt;Ayonayon, Hilsa N.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yaffe%2C+Kristine%22&quot;&gt;Yaffe, Kristine&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Simonsick%2C+Eleanor+M%2E%22&quot;&gt;Simonsick, Eleanor M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Goodpaster%2C+Bret%22&quot;&gt;Goodpaster, Bret&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Health+ABC+Study%22&quot;&gt;Health ABC Study&lt;/searchLink&gt; (CORPORATE AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Geriatric+Psychiatry%22&quot;&gt;International Journal of Geriatric Psychiatry&lt;/searchLink&gt;. Dec2017, Vol. 32 Issue 12, pe166-e172. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Muscle+fatigue%22&quot;&gt;Muscle fatigue&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Old+age%22&quot;&gt;Old age&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Fatigue+%28Physiology%29%22&quot;&gt;Fatigue (Physiology)&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Aging%22&quot;&gt;Aging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychological+aspects+of+aging%22&quot;&gt;Psychological aspects of aging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Skeletal+muscle+physiology%22&quot;&gt;Skeletal muscle physiology&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cross-sectional+method%22&quot;&gt;Cross-sectional method&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Proportional+hazards+models%22&quot;&gt;Proportional hazards models&lt;/searchLink&gt;
– Name: Abstract
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  Data: &lt;bold&gt;Objective: &lt;/bold&gt;Fatigability is the degree to which performance decreases during a specific activity of a given intensity and duration. Depression is known to heighten subjective fatigue, but whether its association with physical fatigability is unknown. Further, whether fatigability is a precursor or risk factor for the development of subsequent depressive symptoms is also unclear.&lt;bold&gt;Methods: &lt;/bold&gt;Data are from the Health Aging and Body Composition Study with fatigability assessed using isokinetic dynamometry of the knee extensors at year 3, and depressive symptoms ascertained longitudinally using the Center for Epidemiologic Studies Depression (CES-D) scale. The relationship between fatigability and depressive symptoms was evaluated using linear and Cox regression models.&lt;bold&gt;Results: &lt;/bold&gt;There was a significant cross-sectional association between fatigability and depressive symptomatology (β&#160;=&#160;-0.06, p&#160;=&#160;0.02), after adjusting for demographic variables, medical comorbidities, cognition, gait speed, and physical activity levels. Greater fatigability was associated with greater adjusted scores on the 10-item CES-D (F2, 1695 &#160;=&#160;38.65, p&#160;&lt;&#160;0.001), with individuals with greater fatigability on average reporting an adjusted CES-D score 0.5 point greater than those individuals with higher levels of resistance to fatigability (mean of 70% or better; p&#160;&lt;&#160;0.001). Fatigability however was not associated with the development of depression at follow-up (p&#160;=&#160;0.828).&lt;bold&gt;Conclusions: &lt;/bold&gt;This study found an association between skeletal muscle fatigability and higher depressive symptoms in older adults, but no longitudinal association was identified. These findings suggest that age-related changes in energy capacity may affect the phenomenology of late life depression. Copyright &#169; 2017 John Wiley &amp; Sons, Ltd. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1002/gps.4678
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        Text: English
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        PageCount: 9
        StartPage: e166
    Subjects:
      – SubjectFull: Muscle fatigue
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Old age
        Type: general
      – SubjectFull: Fatigue (Physiology)
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      – SubjectFull: Aging
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      – SubjectFull: Psychological aspects of aging
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      – SubjectFull: Skeletal muscle physiology
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      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Proportional hazards models
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      – TitleFull: Muscle fatigability and depressive symptoms in later life.
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              M: 12
              Text: Dec2017
              Type: published
              Y: 2017
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