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Efficacy of ketogenic diet for infantile spasms: A systematic review.

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Title: Efficacy of ketogenic diet for infantile spasms: A systematic review.
Authors: Prezioso, G., Carlone, G., Zaccara, G., Verrotti, A.
Source: Acta Neurologica Scandinavica. Jan2018, Vol. 137 Issue 1, p4-11. 8p.
Subjects: Ketogenic diet, Infantile spasms, Etiology of diseases, Follow-up studies (Medicine), Systematic reviews
Abstract: The aim of this systematic review was to collect and analyze all the RCTs and observational studies investigating the efficacy of ketogenic diet ( KD) in infantile spasms ( IS) patients after a 1- to 6-month follow-up period, in terms of decrease in seizure frequency of >50% or a seizure-free interval. Moreover, the potential effect of gender, IS etiology, age at onset of IS, and age at start of KD have been investigated. Finally, we evaluated the seizure-free rate at 12 and 24 months of follow-up. In June 2016, a computer search was performed on MedLine (PubMed), EMBASE, and the Cochrane Library. Only, English language studies conducted after 1980 and those reporting in detail the variation in seizure frequency have been selected. Thirteen observational studies (341 patients) were included in the final analysis. A median rate of 64.7% of patients experienced a spasm reduction >50% ( IQR: 38.94%). The median spasm-free rate was 34.61% ( IQR: 37.94%). IS of unknown etiology seemed to have an increased probability of achieving freedom from seizures ( RR: 1.72, 95% CI: 1.18-2.53). Long-time follow-up data revealed a median seizure-free rate of 9.54% ( IQR: 18.23%). Although the literature is still lacking in high-quality studies, which could provide a stronger level evidence, our findings suggest a potential benefit of KD for drug-resistant IS patients. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Efficacy of ketogenic diet for infantile spasms: A systematic review.
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  Data: <searchLink fieldCode="AR" term="%22Prezioso%2C+G%2E%22">Prezioso, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Carlone%2C+G%2E%22">Carlone, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Zaccara%2C+G%2E%22">Zaccara, G.</searchLink><br /><searchLink fieldCode="AR" term="%22Verrotti%2C+A%2E%22">Verrotti, A.</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Ketogenic+diet%22">Ketogenic diet</searchLink><br /><searchLink fieldCode="DE" term="%22Infantile+spasms%22">Infantile spasms</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology+of+diseases%22">Etiology of diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Follow-up+studies+%28Medicine%29%22">Follow-up studies (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink>
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  Data: The aim of this systematic review was to collect and analyze all the RCTs and observational studies investigating the efficacy of ketogenic diet ( KD) in infantile spasms ( IS) patients after a 1- to 6-month follow-up period, in terms of decrease in seizure frequency of >50% or a seizure-free interval. Moreover, the potential effect of gender, IS etiology, age at onset of IS, and age at start of KD have been investigated. Finally, we evaluated the seizure-free rate at 12 and 24 months of follow-up. In June 2016, a computer search was performed on MedLine (PubMed), EMBASE, and the Cochrane Library. Only, English language studies conducted after 1980 and those reporting in detail the variation in seizure frequency have been selected. Thirteen observational studies (341 patients) were included in the final analysis. A median rate of 64.7% of patients experienced a spasm reduction >50% ( IQR: 38.94%). The median spasm-free rate was 34.61% ( IQR: 37.94%). IS of unknown etiology seemed to have an increased probability of achieving freedom from seizures ( RR: 1.72, 95% CI: 1.18-2.53). Long-time follow-up data revealed a median seizure-free rate of 9.54% ( IQR: 18.23%). Although the literature is still lacking in high-quality studies, which could provide a stronger level evidence, our findings suggest a potential benefit of KD for drug-resistant IS patients. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Jan2018
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