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Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage.

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Title: Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage.
Authors: Sykora, M., Putaala, J., Meretoja, A., Tatlisumak, T., Strbian, D.
Source: Acta Neurologica Scandinavica. Jan2018, Vol. 137 Issue 1, p105-108. 4p.
Subjects: Adrenergic beta blockers, Intracerebral hematoma, Stroke, Neuroprotective agents, Hospital admission & discharge, Retrospective studies, Therapeutics
Abstract: Background Beta-blocker therapy has been suggested to have neuroprotective properties in the setting of acute stroke; however, the evidence is weak and contradictory. We aimed to examine the effects of pre-admission therapy with beta-blockers ( BB) on the mortality following spontaneous intracerebral hemorrhage ( ICH). Methods Retrospective analysis of the Helsinki ICH Study database. Results A total of 1013 patients with ICH were included in the analysis. Patients taking BB were significantly older, had a higher premorbid mRS score, had more DNR orders, and more comorbidities as atrial fibrillation, hypertension, diabetes mellitus, ischemic heart disease, and heart failure. After adjustment for age, pre-existing comorbidities, and prior use of antithrombotic and antihypertensive medications, no differences in in-hospital mortality ( OR 1.1, 95% CI 0.8-1.7), 12-month mortality ( OR 1.3, 95% CI 0.9-1.9), and 3-month mortality ( OR 1.2, 95% CI 0.8-1.7) emerged. Conclusion Pre-admission use of BB was not associated with mortality after ICH. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage.
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  Data: <searchLink fieldCode="AR" term="%22Sykora%2C+M%2E%22">Sykora, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Putaala%2C+J%2E%22">Putaala, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Meretoja%2C+A%2E%22">Meretoja, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Tatlisumak%2C+T%2E%22">Tatlisumak, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Strbian%2C+D%2E%22">Strbian, D.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Jan2018, Vol. 137 Issue 1, p105-108. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Adrenergic+beta+blockers%22">Adrenergic beta blockers</searchLink><br /><searchLink fieldCode="DE" term="%22Intracerebral+hematoma%22">Intracerebral hematoma</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke%22">Stroke</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroprotective+agents%22">Neuroprotective agents</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+admission+%26+discharge%22">Hospital admission & discharge</searchLink><br /><searchLink fieldCode="DE" term="%22Retrospective+studies%22">Retrospective studies</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background Beta-blocker therapy has been suggested to have neuroprotective properties in the setting of acute stroke; however, the evidence is weak and contradictory. We aimed to examine the effects of pre-admission therapy with beta-blockers ( BB) on the mortality following spontaneous intracerebral hemorrhage ( ICH). Methods Retrospective analysis of the Helsinki ICH Study database. Results A total of 1013 patients with ICH were included in the analysis. Patients taking BB were significantly older, had a higher premorbid mRS score, had more DNR orders, and more comorbidities as atrial fibrillation, hypertension, diabetes mellitus, ischemic heart disease, and heart failure. After adjustment for age, pre-existing comorbidities, and prior use of antithrombotic and antihypertensive medications, no differences in in-hospital mortality ( OR 1.1, 95% CI 0.8-1.7), 12-month mortality ( OR 1.3, 95% CI 0.9-1.9), and 3-month mortality ( OR 1.2, 95% CI 0.8-1.7) emerged. Conclusion Pre-admission use of BB was not associated with mortality after ICH. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ane.12817
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              Text: Jan2018
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