Information processing from the motor cortices to the subthalamic nucleus and globus pallidus and their somatotopic organizations revealed electrophysiologically in monkeys.
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| Title: | Information processing from the motor cortices to the subthalamic nucleus and globus pallidus and their somatotopic organizations revealed electrophysiologically in monkeys. |
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| Authors: | Iwamuro, Hirokazu, Tachibana, Yoshihisa, Ugawa, Yoshikazu, Saito, Nobuhito, Nambu, Atsushi |
| Source: | European Journal of Neuroscience. Dec2017, Vol. 46 Issue 11, p2684-2701. 18p. |
| Subjects: | Basal ganglia, Motor cortex, Subthalamic nucleus, Globus pallidus, Macaques |
| Abstract: | To understand how the information derived from different motor cortical areas representing different body parts is organized in the basal ganglia, we examined the neuronal responses in the subthalamic nucleus ( STN), and the external ( GPe) and internal ( GPi) segments of the globus pallidus (input, relay and output nuclei, respectively) to stimulation of the orofacial, forelimb and hindlimb regions of the primary motor cortex ( MI) and supplementary motor area ( SMA) in macaque monkeys under the awake state. Most STN and GPe/ GPi neurons responded exclusively to stimulation of either the MI or SMA, and one-fourth to one-third of neurons responded to both. STN neurons responding to the hindlimb, forelimb and orofacial regions of the MI were located along the medial-lateral axis in the posterolateral STN, while neurons responding to the orofacial region of the SMA were located more medially than the others in the anteromedial STN. GPe/ GPi neurons responding to the hindlimb, forelimb and orofacial regions of the MI were found along the dorsal-ventral axis in the posterolateral GPe/ GPi, and neurons responding to the corresponding regions of the SMA were similarly but less clearly distributed in more anteromedial regions. Moreover, neurons responding to the distal and proximal forelimb MI regions were found along the lateral-medial axis in the STN and the ventral-dorsal axis in the GPe/ GPi. Most STN and GPe/ GPi neurons showed kinaesthetic responses with similar somatotopic maps. These observations suggest that the somatotopically organized inputs from the MI and SMA are well preserved in the STN and GPe/ GPi with partial convergence. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 126563793 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Information processing from the motor cortices to the subthalamic nucleus and globus pallidus and their somatotopic organizations revealed electrophysiologically in monkeys. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Iwamuro%2C+Hirokazu%22">Iwamuro, Hirokazu</searchLink><br /><searchLink fieldCode="AR" term="%22Tachibana%2C+Yoshihisa%22">Tachibana, Yoshihisa</searchLink><br /><searchLink fieldCode="AR" term="%22Ugawa%2C+Yoshikazu%22">Ugawa, Yoshikazu</searchLink><br /><searchLink fieldCode="AR" term="%22Saito%2C+Nobuhito%22">Saito, Nobuhito</searchLink><br /><searchLink fieldCode="AR" term="%22Nambu%2C+Atsushi%22">Nambu, Atsushi</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Dec2017, Vol. 46 Issue 11, p2684-2701. 18p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Basal+ganglia%22">Basal ganglia</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+cortex%22">Motor cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Subthalamic+nucleus%22">Subthalamic nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Globus+pallidus%22">Globus pallidus</searchLink><br /><searchLink fieldCode="DE" term="%22Macaques%22">Macaques</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: To understand how the information derived from different motor cortical areas representing different body parts is organized in the basal ganglia, we examined the neuronal responses in the subthalamic nucleus ( STN), and the external ( GPe) and internal ( GPi) segments of the globus pallidus (input, relay and output nuclei, respectively) to stimulation of the orofacial, forelimb and hindlimb regions of the primary motor cortex ( MI) and supplementary motor area ( SMA) in macaque monkeys under the awake state. Most STN and GPe/ GPi neurons responded exclusively to stimulation of either the MI or SMA, and one-fourth to one-third of neurons responded to both. STN neurons responding to the hindlimb, forelimb and orofacial regions of the MI were located along the medial-lateral axis in the posterolateral STN, while neurons responding to the orofacial region of the SMA were located more medially than the others in the anteromedial STN. GPe/ GPi neurons responding to the hindlimb, forelimb and orofacial regions of the MI were found along the dorsal-ventral axis in the posterolateral GPe/ GPi, and neurons responding to the corresponding regions of the SMA were similarly but less clearly distributed in more anteromedial regions. Moreover, neurons responding to the distal and proximal forelimb MI regions were found along the lateral-medial axis in the STN and the ventral-dorsal axis in the GPe/ GPi. Most STN and GPe/ GPi neurons showed kinaesthetic responses with similar somatotopic maps. These observations suggest that the somatotopically organized inputs from the MI and SMA are well preserved in the STN and GPe/ GPi with partial convergence. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.13738 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 18 StartPage: 2684 Subjects: – SubjectFull: Basal ganglia Type: general – SubjectFull: Motor cortex Type: general – SubjectFull: Subthalamic nucleus Type: general – SubjectFull: Globus pallidus Type: general – SubjectFull: Macaques Type: general Titles: – TitleFull: Information processing from the motor cortices to the subthalamic nucleus and globus pallidus and their somatotopic organizations revealed electrophysiologically in monkeys. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Iwamuro, Hirokazu – PersonEntity: Name: NameFull: Tachibana, Yoshihisa – PersonEntity: Name: NameFull: Ugawa, Yoshikazu – PersonEntity: Name: NameFull: Saito, Nobuhito – PersonEntity: Name: NameFull: Nambu, Atsushi IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2017 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 46 – Type: issue Value: 11 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
