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Positron emission tomography in Parkinson’s disease: insights into impulsivity.

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Title: Positron emission tomography in Parkinson’s disease: insights into impulsivity.
Authors: Stark, Adam J. (AUTHOR), Claassen, Daniel O. (AUTHOR)
Source: International Review of Psychiatry. Dec2017, Vol. 29 Issue 6, p618-627. 10p.
Subjects: Amygdaloid body, Biomarkers, Compulsive behavior, Dopamine, Ligands (Biochemistry), Parkinson's disease, Positron emission tomography, Membrane transport proteins, Symptoms
Abstract: This study reviews previous studies that employ positron emission tomography (PET) imaging assessments in Parkinson’s disease (PD) patients with and without Impulsive Compulsive Behaviours (ICB). This begins with a summary of the potential benefits and limitations of commonly utilized ligands, specifically D2/3receptor and dopamine transporter ligands. Since previous findings emphasize the role of the ventral striatum in the manifestation of ICBs, this study attempts to relate these imaging findings to changes in behaviour, especially emphasizing work performed in substance abuse and addiction. Next, it reviews how increasing disease duration in PD can influence dopamine receptor expression, with an emphasis on differential striatal and extra-striatal changes that occur along the course of PD. Finally, it focuses on how extra-striatal changes, particularly in the orbitofrontal cortex, amygdala, and anterior cingulate, may influence the proficiency of behavioural regulation in PD. The discussion emphasizes the interaction of disease and medication effects on network-wide changes that occur in PD, and how these changes may result in behavioural dysregulation. [ABSTRACT FROM AUTHOR]
Copyright of International Review of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Positron emission tomography in Parkinson’s disease: insights into impulsivity.
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  Data: <searchLink fieldCode="AR" term="%22Stark%2C+Adam+J%2E%22">Stark, Adam J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Claassen%2C+Daniel+O%2E%22">Claassen, Daniel O.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22International+Review+of+Psychiatry%22">International Review of Psychiatry</searchLink>. Dec2017, Vol. 29 Issue 6, p618-627. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Compulsive+behavior%22">Compulsive behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine%22">Dopamine</searchLink><br /><searchLink fieldCode="DE" term="%22Ligands+%28Biochemistry%29%22">Ligands (Biochemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Positron+emission+tomography%22">Positron emission tomography</searchLink><br /><searchLink fieldCode="DE" term="%22Membrane+transport+proteins%22">Membrane transport proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study reviews previous studies that employ positron emission tomography (PET) imaging assessments in Parkinson’s disease (PD) patients with and without Impulsive Compulsive Behaviours (ICB). This begins with a summary of the potential benefits and limitations of commonly utilized ligands, specifically D2/3receptor and dopamine transporter ligands. Since previous findings emphasize the role of the ventral striatum in the manifestation of ICBs, this study attempts to relate these imaging findings to changes in behaviour, especially emphasizing work performed in substance abuse and addiction. Next, it reviews how increasing disease duration in PD can influence dopamine receptor expression, with an emphasis on differential striatal and extra-striatal changes that occur along the course of PD. Finally, it focuses on how extra-striatal changes, particularly in the orbitofrontal cortex, amygdala, and anterior cingulate, may influence the proficiency of behavioural regulation in PD. The discussion emphasizes the interaction of disease and medication effects on network-wide changes that occur in PD, and how these changes may result in behavioural dysregulation. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Review of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/09540261.2017.1398139
    Languages:
      – Code: eng
        Text: English
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        PageCount: 10
        StartPage: 618
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      – SubjectFull: Amygdaloid body
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Compulsive behavior
        Type: general
      – SubjectFull: Dopamine
        Type: general
      – SubjectFull: Ligands (Biochemistry)
        Type: general
      – SubjectFull: Parkinson's disease
        Type: general
      – SubjectFull: Positron emission tomography
        Type: general
      – SubjectFull: Membrane transport proteins
        Type: general
      – SubjectFull: Symptoms
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      – TitleFull: Positron emission tomography in Parkinson’s disease: insights into impulsivity.
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            NameFull: Stark, Adam J.
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              M: 12
              Text: Dec2017
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              Y: 2017
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