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Low clinical conversion rate in clinically isolated syndrome patients – diagnostic benefit of McDonald 2010 criteria?

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Title: Low clinical conversion rate in clinically isolated syndrome patients – diagnostic benefit of McDonald 2010 criteria?
Authors: Rosenkranz, S. C., Kaulen, B., Neuhaus, A., Siemonsen, S., Köpke, S., Daumer, M., Stellmann, J.‐P., Heesen, C.
Source: European Journal of Neurology. Feb2018, Vol. 25 Issue 2, p247-e9. 7p. 1 Diagram, 3 Charts.
Subjects: Multiple sclerosis diagnosis, Multiple sclerosis, Multiple sclerosis treatment, Magnetic resonance imaging, Cerebrospinal fluid, Patients
Abstract: Background and purpose: New diagnostic criteria of multiple sclerosis (MS) increase the number of patients being diagnosed with MS whilst a substantial part might not convert to clinically definite MS (CDMS). The diagnostic accuracy of the McDonald 2005 and 2010 criteria for conversion to CDMS was evaluated in an unselected cohort of patients in whom an MS diagnostic work‐up was decided. Methods: Clinical, magnetic resonance imaging and cerebrospinal fluid data were analysed for all patients who presented with symptoms suspicious for MS at the university based MS outpatient clinic between 2006 and 2010 (n = 165). Results: Follow‐up was available for 131 patients. During the mean follow‐up period of 2 years, 19% of patients developed CDMS whereas 64% of the patients fulfilling McDonald 2010 criteria did not convert to CDMS. Conclusion: The low clinical conversion rate indicates that the new diagnostic criteria may increase the incidence of MS cases with a less active disease course. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Low clinical conversion rate in clinically isolated syndrome patients – diagnostic benefit of McDonald 2010 criteria?
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  Data: <searchLink fieldCode="AR" term="%22Rosenkranz%2C+S%2E+C%2E%22">Rosenkranz, S. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Kaulen%2C+B%2E%22">Kaulen, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Neuhaus%2C+A%2E%22">Neuhaus, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Siemonsen%2C+S%2E%22">Siemonsen, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Köpke%2C+S%2E%22">Köpke, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Daumer%2C+M%2E%22">Daumer, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Stellmann%2C+J%2E‐P%2E%22">Stellmann, J.‐P.</searchLink><br /><searchLink fieldCode="AR" term="%22Heesen%2C+C%2E%22">Heesen, C.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neurology%22">European Journal of Neurology</searchLink>. Feb2018, Vol. 25 Issue 2, p247-e9. 7p. 1 Diagram, 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Multiple+sclerosis+diagnosis%22">Multiple sclerosis diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis%22">Multiple sclerosis</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+sclerosis+treatment%22">Multiple sclerosis treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebrospinal+fluid%22">Cerebrospinal fluid</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Label: Abstract
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  Data: Background and purpose: New diagnostic criteria of multiple sclerosis (MS) increase the number of patients being diagnosed with MS whilst a substantial part might not convert to clinically definite MS (CDMS). The diagnostic accuracy of the McDonald 2005 and 2010 criteria for conversion to CDMS was evaluated in an unselected cohort of patients in whom an MS diagnostic work‐up was decided. Methods: Clinical, magnetic resonance imaging and cerebrospinal fluid data were analysed for all patients who presented with symptoms suspicious for MS at the university based MS outpatient clinic between 2006 and 2010 (<italic>n</italic> = 165). Results: Follow‐up was available for 131 patients. During the mean follow‐up period of 2 years, 19% of patients developed CDMS whereas 64% of the patients fulfilling McDonald 2010 criteria did not convert to CDMS. Conclusion: The low clinical conversion rate indicates that the new diagnostic criteria may increase the incidence of MS cases with a less active disease course. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Feb2018
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