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Endothelial colony‐forming cells and pro‐angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury.

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Title: Endothelial colony‐forming cells and pro‐angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury.
Authors: Basile, D. P., Collett, J. A., Yoder, M. C.
Source: Acta Physiologica. Feb2018, Vol. 222 Issue 2, p1-1. 17p. 1 Color Photograph, 4 Diagrams, 1 Chart.
Subjects: Endothelial cells, Vascular endothelial growth factors, Kidney diseases, Nephrotoxicology, Vasoconstriction
Abstract: Abstract: Acute kidney injury (AKI) represents a significant clinical concern that is associated with high mortality rates and also represents a significant risk factor for the development of chronic kidney disease (CKD). This article will consider alterations in renal endothelial function in the setting of AKI that may underlie impairment in renal perfusion and how inefficient vascular repair may manifest post‐AKI and contribute to the potential transition to CKD. We provide updated terminology for cells previously classified as ‘endothelial progenitor’ that may mediate vascular repair such as pro‐angiogenic cells and endothelial colony‐forming cells. We consider how endothelial repair may be mediated by these different cell types following vascular injury, particularly in models of AKI. We further summarize the potential ability of these different cells to mitigate the severity of AKI, improve perfusion and maintain vascular structure in pre‐clinical studies. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Endothelial colony‐forming cells and pro‐angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury.
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  Data: <searchLink fieldCode="AR" term="%22Basile%2C+D%2E+P%2E%22">Basile, D. P.</searchLink><br /><searchLink fieldCode="AR" term="%22Collett%2C+J%2E+A%2E%22">Collett, J. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Yoder%2C+M%2E+C%2E%22">Yoder, M. C.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Feb2018, Vol. 222 Issue 2, p1-1. 17p. 1 Color Photograph, 4 Diagrams, 1 Chart.
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  Data: <searchLink fieldCode="DE" term="%22Endothelial+cells%22">Endothelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+endothelial+growth+factors%22">Vascular endothelial growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+diseases%22">Kidney diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Nephrotoxicology%22">Nephrotoxicology</searchLink><br /><searchLink fieldCode="DE" term="%22Vasoconstriction%22">Vasoconstriction</searchLink>
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  Data: Abstract: Acute kidney injury (AKI) represents a significant clinical concern that is associated with high mortality rates and also represents a significant risk factor for the development of chronic kidney disease (CKD). This article will consider alterations in renal endothelial function in the setting of AKI that may underlie impairment in renal perfusion and how inefficient vascular repair may manifest post‐AKI and contribute to the potential transition to CKD. We provide updated terminology for cells previously classified as ‘endothelial progenitor’ that may mediate vascular repair such as pro‐angiogenic cells and endothelial colony‐forming cells. We consider how endothelial repair may be mediated by these different cell types following vascular injury, particularly in models of AKI. We further summarize the potential ability of these different cells to mitigate the severity of AKI, improve perfusion and maintain vascular structure in pre‐clinical studies. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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