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Deletion of the EGF receptor in vascular smooth muscle cells prevents chronic angiotensin II‐induced arterial wall stiffening and media thickening.

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Title: Deletion of the EGF receptor in vascular smooth muscle cells prevents chronic angiotensin II‐induced arterial wall stiffening and media thickening.
Authors: Schreier, B., Hünerberg, M., Mildenberger, S., Rabe, S., Bethmann, D., Wickenhauser, C., Gekle, M.
Source: Acta Physiologica. Mar2018, Vol. 222 Issue 3, p1-1. 14p. 1 Chart, 6 Graphs.
Subjects: Epidermal growth factor receptors, Vascular smooth muscle, Muscle cells, Vascular remodeling, Blood pressure
Abstract: Abstract: Aim: In vivo vascular smooth muscle cell (VSMC) EGF receptor (EGFR) contributes to acute angiotensin II (AII) effects on vascular tone and blood pressure. The ubiquitously expressed EGFR has been implicated in vascular remodelling preceding end‐organ damage by pharmacological inhibition, and AII signalling in cultured vascular cells is partly EGFR‐dependent. However, the role of VSMC‐EGFR in vivo during AII‐induced pathophysiological processes is not known. Methods: This study assesses the in vivo relevance of VSMC‐EGFR during chronic AII challenge without further stressors, using a mouse model with inducible, VSMC‐specific EGFR knock out (VSMC‐EGFR‐KO). In these mice functional and structural vascular, renal and cardiac effects or biomarkers were investigated in vivo and ex vivo. Results: Vascular smooth muscle cell‐EGFR‐KO prevented AII‐induced media hypertrophy of mesenteric arteries, renal arterioles and the aorta, VSMC ERK1/2‐phosphorylation as well as the impairment of vascular compliance. Furthermore, induction of vascular fibrosis, creatinineamia, renal interstitial fibrosis as well as the increase in fractional water excretion was prevented. AII‐induced increase in systolic blood pressure was mitigated. By contrast, endothelial dysfunction, induction of vascular inflammatory marker mRNA and albuminuria were not inhibited. Cardiac and cardiomyocyte hypertrophy were also not prevented by VSMC‐EGFR‐KO. Conclusion: Vascular smooth muscle cell‐EGFRs are relevant for pathological AII action in vivo. Our data show in vivo and ex vivo the necessity of VSMC‐EGFR for AII‐induced structural and functional vascular remodelling, not including endothelial dysfunction. Hereby, VSMC‐EGFR gains importance for complete AII‐induced renal end‐organ damage succeeding vascular remodelling. [ABSTRACT FROM AUTHOR]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Deletion of the EGF receptor in vascular smooth muscle cells prevents chronic angiotensin II‐induced arterial wall stiffening and media thickening.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Mar2018, Vol. 222 Issue 3, p1-1. 14p. 1 Chart, 6 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Epidermal+growth+factor+receptors%22">Epidermal growth factor receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+smooth+muscle%22">Vascular smooth muscle</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+cells%22">Muscle cells</searchLink><br /><searchLink fieldCode="DE" term="%22Vascular+remodeling%22">Vascular remodeling</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink>
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  Data: Abstract: Aim: In vivo vascular smooth muscle cell (VSMC) EGF receptor (EGFR) contributes to acute angiotensin II (AII) effects on vascular tone and blood pressure. The ubiquitously expressed EGFR has been implicated in vascular remodelling preceding end‐organ damage by pharmacological inhibition, and AII signalling in cultured vascular cells is partly EGFR‐dependent. However, the role of VSMC‐EGFR in vivo during AII‐induced pathophysiological processes is not known. Methods: This study assesses the in vivo relevance of VSMC‐EGFR during chronic AII challenge without further stressors, using a mouse model with inducible, VSMC‐specific EGFR knock out (VSMC‐EGFR‐KO). In these mice functional and structural vascular, renal and cardiac effects or biomarkers were investigated in vivo and ex vivo. Results: Vascular smooth muscle cell‐EGFR‐KO prevented AII‐induced media hypertrophy of mesenteric arteries, renal arterioles and the aorta, VSMC ERK1/2‐phosphorylation as well as the impairment of vascular compliance. Furthermore, induction of vascular fibrosis, creatinineamia, renal interstitial fibrosis as well as the increase in fractional water excretion was prevented. AII‐induced increase in systolic blood pressure was mitigated. By contrast, endothelial dysfunction, induction of vascular inflammatory marker mRNA and albuminuria were not inhibited. Cardiac and cardiomyocyte hypertrophy were also not prevented by VSMC‐EGFR‐KO. Conclusion: Vascular smooth muscle cell‐EGFRs are relevant for pathological AII action in vivo. Our data show in vivo and ex vivo the necessity of VSMC‐EGFR for AII‐induced structural and functional vascular remodelling, not including endothelial dysfunction. Hereby, VSMC‐EGFR gains importance for complete AII‐induced renal end‐organ damage succeeding vascular remodelling. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Deletion of the EGF receptor in vascular smooth muscle cells prevents chronic angiotensin II‐induced arterial wall stiffening and media thickening.
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              Text: Mar2018
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