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Envelope-Constrained Neutralization-Sensitive HIV-1 AfterHeterosexual Transmission.

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Title: Envelope-Constrained Neutralization-Sensitive HIV-1 AfterHeterosexual Transmission.
Authors: Derdeyn,, Cynthia A., Decker, Julie M., Bibollet-Ruche, Frederic, Mokili, John L., Muldoon, Mark, Denham, Scott A., Heil, Marintha L., Kasolo, Francis, Musonda, Rosemary, Hahn, Beatrice H., Shaw, George M., Korber, Bette T., Allen, Susan, Hunter, Eric
Source: Science (pre-March 2025). 3/26/2004, Vol. 303 Issue 5666, p2019-2022. 4p. 2 Diagrams, 2 Graphs.
Subjects: HIV infections, HIV, Immunity, Glycoproteins, Epitopes, Vaccines
Abstract: Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Envelope-Constrained Neutralization-Sensitive HIV-1 AfterHeterosexual Transmission.
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  Data: <searchLink fieldCode="AR" term="%22Derdeyn%2C%2C+Cynthia+A%2E%22">Derdeyn,, Cynthia A.</searchLink><br /><searchLink fieldCode="AR" term="%22Decker%2C+Julie+M%2E%22">Decker, Julie M.</searchLink><br /><searchLink fieldCode="AR" term="%22Bibollet-Ruche%2C+Frederic%22">Bibollet-Ruche, Frederic</searchLink><br /><searchLink fieldCode="AR" term="%22Mokili%2C+John+L%2E%22">Mokili, John L.</searchLink><br /><searchLink fieldCode="AR" term="%22Muldoon%2C+Mark%22">Muldoon, Mark</searchLink><br /><searchLink fieldCode="AR" term="%22Denham%2C+Scott+A%2E%22">Denham, Scott A.</searchLink><br /><searchLink fieldCode="AR" term="%22Heil%2C+Marintha+L%2E%22">Heil, Marintha L.</searchLink><br /><searchLink fieldCode="AR" term="%22Kasolo%2C+Francis%22">Kasolo, Francis</searchLink><br /><searchLink fieldCode="AR" term="%22Musonda%2C+Rosemary%22">Musonda, Rosemary</searchLink><br /><searchLink fieldCode="AR" term="%22Hahn%2C+Beatrice+H%2E%22">Hahn, Beatrice H.</searchLink><br /><searchLink fieldCode="AR" term="%22Shaw%2C+George+M%2E%22">Shaw, George M.</searchLink><br /><searchLink fieldCode="AR" term="%22Korber%2C+Bette+T%2E%22">Korber, Bette T.</searchLink><br /><searchLink fieldCode="AR" term="%22Allen%2C+Susan%22">Allen, Susan</searchLink><br /><searchLink fieldCode="AR" term="%22Hunter%2C+Eric%22">Hunter, Eric</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 3/26/2004, Vol. 303 Issue 5666, p2019-2022. 4p. 2 Diagrams, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22HIV%22">HIV</searchLink><br /><searchLink fieldCode="DE" term="%22Immunity%22">Immunity</searchLink><br /><searchLink fieldCode="DE" term="%22Glycoproteins%22">Glycoproteins</searchLink><br /><searchLink fieldCode="DE" term="%22Epitopes%22">Epitopes</searchLink><br /><searchLink fieldCode="DE" term="%22Vaccines%22">Vaccines</searchLink>
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  Label: Abstract
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  Data: Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=12791504
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        Value: 10.1126/science.1093137
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        Text: English
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      Pagination:
        PageCount: 4
        StartPage: 2019
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      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: HIV
        Type: general
      – SubjectFull: Immunity
        Type: general
      – SubjectFull: Glycoproteins
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      – SubjectFull: Epitopes
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      – SubjectFull: Vaccines
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    Titles:
      – TitleFull: Envelope-Constrained Neutralization-Sensitive HIV-1 AfterHeterosexual Transmission.
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              Text: 3/26/2004
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