View in EDS HTML Full Text PDF Full Text

Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels.

Saved in:
Bibliographic Details
Title: Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels.
Authors: Wehring, Heidi J., Elsobky, Teresa, McEvoy, Joseph P., Vyas, Gopal, Richardson, Charles M., McMahon, Robert P., DiPaula, Bethany A., Liu, Fang, Sullivan, Kelli, Buchanan, Robert W., Feldman, Stephanie, McMahon, Elizabeth M., Kelly, Deanna L.
Source: Psychiatric Quarterly. Mar2018, Vol. 89 Issue 1, p73-80. 8p. 2 Charts, 1 Graph.
Subjects: People with schizophrenia, Adjunctive behavior, Minocycline, Clozapine, Antipsychotic agents
Abstract: Clozapine is the sole antipsychotic agent effective for the treatment of refractory schizophrenia. Sixty percent of clozapine-treated patients, however, fail to adequately respond. Minocycline, a tetracycline antibiotic, possesses antiinflammatory and neuroprotective properties that may play a role in schizophrenia. Clozapine is mainly metabolized by CYP1A2 enzymes, and minocycline may potentially inhibit CYP1A2 as hypothesized by case report data. To date, no pharmacokinetic interaction has been reported between minocycline and clozapine. This is a secondary analysis of a 10-week controlled study of adjunctive minocycline to clozapine in treatment refractory schizophrenia. Clozapine plasma levels were collected every two weeks during the study. 28 participants assigned to receive minocycline and 22 assigned to placebo were included. No differences existed in baseline demographics, clozapine dose or plasma levels. Average changes from baseline in clozapine plasma level (p = 0.033) were significantly higher in the minocycline group despite maintenance of stable doses. No statistically significant treatment differences were found in the norclozapine (p = 0.754) or total clozapine (p = 0.053) changes in plasma levels, although possible changes in total clozapine levels require further investigation. This analysis suggests that minocycline administration may lead to increased clozapine plasma levels. Further study is needed to examine possible explanations. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatric Quarterly is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 127930928
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Wehring%2C+Heidi+J%2E%22">Wehring, Heidi J.</searchLink><br /><searchLink fieldCode="AR" term="%22Elsobky%2C+Teresa%22">Elsobky, Teresa</searchLink><br /><searchLink fieldCode="AR" term="%22McEvoy%2C+Joseph+P%2E%22">McEvoy, Joseph P.</searchLink><br /><searchLink fieldCode="AR" term="%22Vyas%2C+Gopal%22">Vyas, Gopal</searchLink><br /><searchLink fieldCode="AR" term="%22Richardson%2C+Charles+M%2E%22">Richardson, Charles M.</searchLink><br /><searchLink fieldCode="AR" term="%22McMahon%2C+Robert+P%2E%22">McMahon, Robert P.</searchLink><br /><searchLink fieldCode="AR" term="%22DiPaula%2C+Bethany+A%2E%22">DiPaula, Bethany A.</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Fang%22">Liu, Fang</searchLink><br /><searchLink fieldCode="AR" term="%22Sullivan%2C+Kelli%22">Sullivan, Kelli</searchLink><br /><searchLink fieldCode="AR" term="%22Buchanan%2C+Robert+W%2E%22">Buchanan, Robert W.</searchLink><br /><searchLink fieldCode="AR" term="%22Feldman%2C+Stephanie%22">Feldman, Stephanie</searchLink><br /><searchLink fieldCode="AR" term="%22McMahon%2C+Elizabeth+M%2E%22">McMahon, Elizabeth M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kelly%2C+Deanna+L%2E%22">Kelly, Deanna L.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Psychiatric+Quarterly%22">Psychiatric Quarterly</searchLink>. Mar2018, Vol. 89 Issue 1, p73-80. 8p. 2 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Adjunctive+behavior%22">Adjunctive behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Minocycline%22">Minocycline</searchLink><br /><searchLink fieldCode="DE" term="%22Clozapine%22">Clozapine</searchLink><br /><searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Clozapine is the sole antipsychotic agent effective for the treatment of refractory schizophrenia. Sixty percent of clozapine-treated patients, however, fail to adequately respond. Minocycline, a tetracycline antibiotic, possesses antiinflammatory and neuroprotective properties that may play a role in schizophrenia. Clozapine is mainly metabolized by CYP1A2 enzymes, and minocycline may potentially inhibit CYP1A2 as hypothesized by case report data. To date, no pharmacokinetic interaction has been reported between minocycline and clozapine. This is a secondary analysis of a 10-week controlled study of adjunctive minocycline to clozapine in treatment refractory schizophrenia. Clozapine plasma levels were collected every two weeks during the study. 28 participants assigned to receive minocycline and 22 assigned to placebo were included. No differences existed in baseline demographics, clozapine dose or plasma levels. Average changes from baseline in clozapine plasma level (<italic>p</italic> = 0.033) were significantly higher in the minocycline group despite maintenance of stable doses. No statistically significant treatment differences were found in the norclozapine (<italic>p</italic> = 0.754) or total clozapine (<italic>p</italic> = 0.053) changes in plasma levels, although possible changes in total clozapine levels require further investigation. This analysis suggests that minocycline administration may lead to increased clozapine plasma levels. Further study is needed to examine possible explanations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatric Quarterly is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=127930928
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s11126-017-9515-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 73
    Subjects:
      – SubjectFull: People with schizophrenia
        Type: general
      – SubjectFull: Adjunctive behavior
        Type: general
      – SubjectFull: Minocycline
        Type: general
      – SubjectFull: Clozapine
        Type: general
      – SubjectFull: Antipsychotic agents
        Type: general
    Titles:
      – TitleFull: Adjunctive Minocycline in Clozapine-Treated Patients with Schizophrenia: Analyzing the Effects of Minocycline on Clozapine Plasma Levels.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Wehring, Heidi J.
      – PersonEntity:
          Name:
            NameFull: Elsobky, Teresa
      – PersonEntity:
          Name:
            NameFull: McEvoy, Joseph P.
      – PersonEntity:
          Name:
            NameFull: Vyas, Gopal
      – PersonEntity:
          Name:
            NameFull: Richardson, Charles M.
      – PersonEntity:
          Name:
            NameFull: McMahon, Robert P.
      – PersonEntity:
          Name:
            NameFull: DiPaula, Bethany A.
      – PersonEntity:
          Name:
            NameFull: Liu, Fang
      – PersonEntity:
          Name:
            NameFull: Sullivan, Kelli
      – PersonEntity:
          Name:
            NameFull: Buchanan, Robert W.
      – PersonEntity:
          Name:
            NameFull: Feldman, Stephanie
      – PersonEntity:
          Name:
            NameFull: McMahon, Elizabeth M.
      – PersonEntity:
          Name:
            NameFull: Kelly, Deanna L.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 00332720
          Numbering:
            – Type: volume
              Value: 89
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Psychiatric Quarterly
              Type: main
ResultId 1