View in EDS HTML Full Text PDF Full Text

Non‐medical use of psychoactive prescription drugs is associated with fatal poisoning.

Saved in:
Bibliographic Details
Title: Non‐medical use of psychoactive prescription drugs is associated with fatal poisoning.
Authors: Haukka, Jari, Kriikku, Pirkko, Mariottini, Claudia, Partonen, Timo, Ojanperä, Ilkka
Source: Addiction. Mar2018, Vol. 113 Issue 3, p464-472. 9p. 4 Charts, 1 Graph.
Subjects: Medication abuse, Self-poisoning, Drug overdose, Psychiatric drugs
Geographic Terms: Finland
Abstract: Abstract: Aims: The aims of this study were to estimate the prevalence and predictors of non‐medical substance use, and to assess the association between non‐medical substance use and fatal poisoning or history of drug abuse in Finland. Design and setting: Retrospective cohort study of all medico‐legally investigated death cases in Finland. The postmortem toxicology database was linked together with the register on reimbursed prescription medicines. Participants and cases: All postmortem cases between 2011 and 2013 positive for one or more of the following drugs: oxycodone, fentanyl, tramadol, clonazepam, gabapentin, pregabalin, tizanidine, olanzapine, quetiapine, risperidone, alprazolam, zolpidem, mirtazapine and bupropion, n = 2974. Measurements: Non‐medical use of substance was the outcome variable. Predictors were the following: gender, residence at the time of death, place of death, blood alcohol concentration, age, drug abuse, number of prescriptions of any psychoactive drugs in last year and proportion of prescriptions issued by psychiatrist in last year. Findings: In 50.4% of the studied cases, at least one drug was detected without a prescription. Clonazepam, alprazolam and tramadol were the most prevalent non‐medical findings in these cases (6.6, 6.1 and 5.6%, respectively). The risk of non‐medical use of prescription drugs was especially high in cases with history of drug abuse (88.5%) and in fatal poisonings (71.0%). The proportion of non‐medical use of the studied substances varied between 5.9% [95% confidence interval (CI) = 3.1–10.1%)] for risperidone and 55.7% for fentanyl (95% CI = 44.1–66.9%). Valid prescription for one or more of any psychoactive drug was associated with lower odds for non‐medical use of the studied substances. Additionally, the higher the proportion of psychoactive drugs prescribed by a psychiatrist, the lower the probability of non‐medical use. Conclusions: Non‐prescribed psychoactive drugs are found commonly at postmortem in drug poisoning deaths in Finland, with history of drug abuse being a major contributing factor. [ABSTRACT FROM AUTHOR]
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 127932329
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Non‐medical use of psychoactive prescription drugs is associated with fatal poisoning.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Haukka%2C+Jari%22">Haukka, Jari</searchLink><br /><searchLink fieldCode="AR" term="%22Kriikku%2C+Pirkko%22">Kriikku, Pirkko</searchLink><br /><searchLink fieldCode="AR" term="%22Mariottini%2C+Claudia%22">Mariottini, Claudia</searchLink><br /><searchLink fieldCode="AR" term="%22Partonen%2C+Timo%22">Partonen, Timo</searchLink><br /><searchLink fieldCode="AR" term="%22Ojanperä%2C+Ilkka%22">Ojanperä, Ilkka</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Addiction%22">Addiction</searchLink>. Mar2018, Vol. 113 Issue 3, p464-472. 9p. 4 Charts, 1 Graph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medication+abuse%22">Medication abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Self-poisoning%22">Self-poisoning</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+overdose%22">Drug overdose</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+drugs%22">Psychiatric drugs</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Finland%22">Finland</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract: Aims: The aims of this study were to estimate the prevalence and predictors of non‐medical substance use, and to assess the association between non‐medical substance use and fatal poisoning or history of drug abuse in Finland. Design and setting: Retrospective cohort study of all medico‐legally investigated death cases in Finland. The postmortem toxicology database was linked together with the register on reimbursed prescription medicines. Participants and cases: All postmortem cases between 2011 and 2013 positive for one or more of the following drugs: oxycodone, fentanyl, tramadol, clonazepam, gabapentin, pregabalin, tizanidine, olanzapine, quetiapine, risperidone, alprazolam, zolpidem, mirtazapine and bupropion, <italic>n</italic> = 2974. Measurements: Non‐medical use of substance was the outcome variable. Predictors were the following: gender, residence at the time of death, place of death, blood alcohol concentration, age, drug abuse, number of prescriptions of any psychoactive drugs in last year and proportion of prescriptions issued by psychiatrist in last year. Findings: In 50.4% of the studied cases, at least one drug was detected without a prescription. Clonazepam, alprazolam and tramadol were the most prevalent non‐medical findings in these cases (6.6, 6.1 and 5.6%, respectively). The risk of non‐medical use of prescription drugs was especially high in cases with history of drug abuse (88.5%) and in fatal poisonings (71.0%). The proportion of non‐medical use of the studied substances varied between 5.9% [95% confidence interval (CI) = 3.1–10.1%)] for risperidone and 55.7% for fentanyl (95% CI = 44.1–66.9%). Valid prescription for one or more of any psychoactive drug was associated with lower odds for non‐medical use of the studied substances. Additionally, the higher the proportion of psychoactive drugs prescribed by a psychiatrist, the lower the probability of non‐medical use. Conclusions: Non‐prescribed psychoactive drugs are found commonly at postmortem in drug poisoning deaths in Finland, with history of drug abuse being a major contributing factor. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=127932329
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/add.14014
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 464
    Subjects:
      – SubjectFull: Medication abuse
        Type: general
      – SubjectFull: Self-poisoning
        Type: general
      – SubjectFull: Drug overdose
        Type: general
      – SubjectFull: Psychiatric drugs
        Type: general
      – SubjectFull: Finland
        Type: general
    Titles:
      – TitleFull: Non‐medical use of psychoactive prescription drugs is associated with fatal poisoning.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Haukka, Jari
      – PersonEntity:
          Name:
            NameFull: Kriikku, Pirkko
      – PersonEntity:
          Name:
            NameFull: Mariottini, Claudia
      – PersonEntity:
          Name:
            NameFull: Partonen, Timo
      – PersonEntity:
          Name:
            NameFull: Ojanperä, Ilkka
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2018
              Type: published
              Y: 2018
          Identifiers:
            – Type: issn-print
              Value: 09652140
          Numbering:
            – Type: volume
              Value: 113
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: Addiction
              Type: main
ResultId 1