Working memory network alterations in high‐functioning adolescents with an autism spectrum disorder.
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| Title: | Working memory network alterations in high‐functioning adolescents with an autism spectrum disorder. |
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| Authors: | Barendse, Evelien M., Schreuder, Lisanne J., Thoonen, Geert, Hendriks, Marc P. H., Kessels, Roy P. C., Backes, Walter H., Aldenkamp, Albert P., Jansen, Jacobus F. A. |
| Source: | Psychiatry & Clinical Neurosciences. Feb2018, Vol. 72 Issue 2, p73-83. 11p. 1 Color Photograph, 1 Diagram, 2 Charts, 2 Graphs. |
| Subjects: | Autism spectrum disorders, Memory disorders, Short-term memory, Asperger's syndrome, Functional magnetic resonance imaging, Patients |
| Abstract: | Aim: People with autism spectrum disorder (ASD) typically have deficits in the working memory (WM) system. WM is found to be an essential chain in successfully navigating in the social world. We hypothesize that brain networks for WM have an altered network integrity in ASD compared to controls. Methods: Thirteen adolescents (one female) with autistic disorder ( |
| Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 128010531 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Working memory network alterations in high‐functioning adolescents with an autism spectrum disorder. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Barendse%2C+Evelien+M%2E%22">Barendse, Evelien M.</searchLink><br /><searchLink fieldCode="AR" term="%22Schreuder%2C+Lisanne+J%2E%22">Schreuder, Lisanne J.</searchLink><br /><searchLink fieldCode="AR" term="%22Thoonen%2C+Geert%22">Thoonen, Geert</searchLink><br /><searchLink fieldCode="AR" term="%22Hendriks%2C+Marc+P%2E+H%2E%22">Hendriks, Marc P. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Kessels%2C+Roy+P%2E+C%2E%22">Kessels, Roy P. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Backes%2C+Walter+H%2E%22">Backes, Walter H.</searchLink><br /><searchLink fieldCode="AR" term="%22Aldenkamp%2C+Albert+P%2E%22">Aldenkamp, Albert P.</searchLink><br /><searchLink fieldCode="AR" term="%22Jansen%2C+Jacobus+F%2E+A%2E%22">Jansen, Jacobus F. A.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Feb2018, Vol. 72 Issue 2, p73-83. 11p. 1 Color Photograph, 1 Diagram, 2 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Memory+disorders%22">Memory disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Short-term+memory%22">Short-term memory</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+magnetic+resonance+imaging%22">Functional magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim: People with autism spectrum disorder (ASD) typically have deficits in the working memory (WM) system. WM is found to be an essential chain in successfully navigating in the social world. We hypothesize that brain networks for WM have an altered network integrity in ASD compared to controls. Methods: Thirteen adolescents (one female) with autistic disorder (<italic>n</italic> = 1), Asperger's disorder (<italic>n</italic> = 7), or pervasive developmental disorder not otherwise specified (<italic>n</italic> = 5), and 13 typically developing healthy control adolescents (one female) participated in this study. Functional magnetic resonance imaging (MRI) was performed using an n‐back task and in resting state. Results: The analysis of the behavioral data revealed deficits in WM performance in ASD, but only when tested to the limit. Adolescents with ASD showed lower binary global efficiency in the WM network than the healthy control group with n‐back and resting‐state data. This correlated with diagnostic scores for total problems, reciprocity, and language. Conclusion: Adolescents with higher‐functioning autism have difficulty with the WM system, which is typically compensated. Functional MRI markers of brain network organization in ASD are related to characteristics of autism as represented in diagnostic scores. Therefore, functional MRI provides neuronal correlates for memory difficulties in adolescents with ASD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/pcn.12602 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 73 Subjects: – SubjectFull: Autism spectrum disorders Type: general – SubjectFull: Memory disorders Type: general – SubjectFull: Short-term memory Type: general – SubjectFull: Asperger's syndrome Type: general – SubjectFull: Functional magnetic resonance imaging Type: general – SubjectFull: Patients Type: general Titles: – TitleFull: Working memory network alterations in high‐functioning adolescents with an autism spectrum disorder. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Barendse, Evelien M. – PersonEntity: Name: NameFull: Schreuder, Lisanne J. – PersonEntity: Name: NameFull: Thoonen, Geert – PersonEntity: Name: NameFull: Hendriks, Marc P. H. – PersonEntity: Name: NameFull: Kessels, Roy P. C. – PersonEntity: Name: NameFull: Backes, Walter H. – PersonEntity: Name: NameFull: Aldenkamp, Albert P. – PersonEntity: Name: NameFull: Jansen, Jacobus F. A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 13231316 Numbering: – Type: volume Value: 72 – Type: issue Value: 2 Titles: – TitleFull: Psychiatry & Clinical Neurosciences Type: main |
| ResultId | 1 |
