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A study of single nucleotide polymorphisms in CD157, AIM2 and JARID2 genes in Han Chinese children with autism spectrum disorder.

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Title: A study of single nucleotide polymorphisms in CD157, AIM2 and JARID2 genes in Han Chinese children with autism spectrum disorder.
Authors: Mo, Weiming (AUTHOR), Liu, Jun (AUTHOR), Zhang, Zengyu (AUTHOR), Yu, Hong (AUTHOR), Yang, Aiping (AUTHOR), Qu, Fei (AUTHOR), Hu, Pingfang (AUTHOR), Liu, Zhuo (AUTHOR), Hu, Fengpei (AUTHOR)
Source: Nordic Journal of Psychiatry. 2018, Vol. 72 Issue 3, p179-183. 5p.
Subjects: Autism spectrum disorders, Neural development, Single nucleotide polymorphisms, Genotype-environment interaction, Immune system
Abstract: Purpose: Autism spectrum disorder (ASD) is a group of developmental brain disorders caused by genetic and environmental factors. The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes related to immune function were associated with ASD in Chinese Han children. Materials and methods: A total of 201 children with ASD and 200 age- and gender-matched healthy controls were recruited from September 2012 to June 2106. A TaqMan probe-based approach was used to genotype SNPs corresponding to rs28532698 and rs4301112 in CD157, rs855867 in AIM2, and rs2237126 in JARID2. Case-control and case-only studies were performed to determine the contribution of SNPs to the predisposition of disease and its severity, respectively. Results: Our results revealed that the genotypes and allele frequencies of these SNPs were not significantly associated with childhood ASD and its severity in this population. Conclusions: Results of our study suggest that these SNPs are not predictors of childhood ASD in the Chinese Han population. The discrepant results suggest the predictor roles of SNPs have to be determined in different ethnic populations due to genetic heterogeneity of ASD. [ABSTRACT FROM AUTHOR]
Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: A study of single nucleotide polymorphisms in CD157, AIM2 and JARID2 genes in Han Chinese children with autism spectrum disorder.
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  Data: <searchLink fieldCode="AR" term="%22Mo%2C+Weiming%22">Mo, Weiming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Jun%22">Liu, Jun</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Zengyu%22">Zhang, Zengyu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yu%2C+Hong%22">Yu, Hong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Aiping%22">Yang, Aiping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qu%2C+Fei%22">Qu, Fei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Pingfang%22">Hu, Pingfang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Zhuo%22">Liu, Zhuo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hu%2C+Fengpei%22">Hu, Fengpei</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nordic+Journal+of+Psychiatry%22">Nordic Journal of Psychiatry</searchLink>. 2018, Vol. 72 Issue 3, p179-183. 5p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Genotype-environment+interaction%22">Genotype-environment interaction</searchLink><br /><searchLink fieldCode="DE" term="%22Immune+system%22">Immune system</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Autism spectrum disorder (ASD) is a group of developmental brain disorders caused by genetic and environmental factors. The objective of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes related to immune function were associated with ASD in Chinese Han children. Materials and methods: A total of 201 children with ASD and 200 age- and gender-matched healthy controls were recruited from September 2012 to June 2106. A TaqMan probe-based approach was used to genotype SNPs corresponding to rs28532698 and rs4301112 in CD157, rs855867 in AIM2, and rs2237126 in JARID2. Case-control and case-only studies were performed to determine the contribution of SNPs to the predisposition of disease and its severity, respectively. Results: Our results revealed that the genotypes and allele frequencies of these SNPs were not significantly associated with childhood ASD and its severity in this population. Conclusions: Results of our study suggest that these SNPs are not predictors of childhood ASD in the Chinese Han population. The discrepant results suggest the predictor roles of SNPs have to be determined in different ethnic populations due to genetic heterogeneity of ASD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: 2018
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