Clinical improvement, relapse and treatment adherence with paliperidone palmitate 1-month formulation: 1-year treatment in a naturalistic outpatient setting.
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| Title: | Clinical improvement, relapse and treatment adherence with paliperidone palmitate 1-month formulation: 1-year treatment in a naturalistic outpatient setting. |
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| Authors: | Di Lorenzo, Rosaria (AUTHOR), Cameli, Michela (AUTHOR), Piemonte, Chiara (AUTHOR), Bolondi, Marisa (AUTHOR), Landi, Giulia (AUTHOR), Pollutri, Gabriella (AUTHOR), Spattini, Ludovica (AUTHOR), Moretti, Valentina (AUTHOR), Ferri, Paola (AUTHOR) |
| Source: | Nordic Journal of Psychiatry. 2018, Vol. 72 Issue 3, p214-220. 7p. |
| Subjects: | People with schizophrenia, Psychotherapy, Pathological psychology, Mental health services, Outpatient medical care |
| Abstract: | Purpose: To evaluate paliperidone palmitate 1-month formulation (PP1M) effectiveness in a naturalistic outpatient psychiatric setting. Materials and methods: We collected data from 50 outpatients affected by schizophrenia disorders treated with PP1M for 12 months in an Italian Mental Health Department. After analyzing selected demographic, clinical and pharmacological variables, we performed mirror analysis to compare psychiatric hospitalizations and urgent consultations required by the same patient 6 and 12 months before and after PP1M implementation (primary outcome). We analyzed clinical improvement in symptom (Clinical Global Impression-severity and improvement) and functioning (Global Assessment of Functioning) scales and drop-out rate during the 12-month PP1M treatment (secondary outcome). Data were statistically analyzed. Results: The mean PP1M dose was 93.5mg (±27.7 SD) with a mean interval between each injection of 27.1 d (±4.5 SD). Twenty-three patients (46%) reported adverse effects (sexual dysfunctions, weight gain and extrapyramidal symptoms).Fifteen patients (30%) dropped out after 137.2 d (±103.1 SD) on average: six due to the lack of therapeutic adherence, six due to inefficacy and three due to adverse events. The drop-out patients presented more severe clinical profile in CGI-S and GAF scores at T0 in comparison with others. At mirror analysis, 12-month but not 6-month PP1M treatment statistically significantly reduced psychiatric hospitalizations (t=2.3, p<.05) and urgent consultations (t=2.1, p<.05). Both scale scores showed statistically significant improvement at T12 in comparison to T0. Conclusions: This naturalistic study indicates that long-term PP1M treatment was safe and effective in preventing hospitalizations and urgent consultations as well as in improving clinical course. [ABSTRACT FROM AUTHOR] |
| Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 128084911 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinical improvement, relapse and treatment adherence with paliperidone palmitate 1-month formulation: 1-year treatment in a naturalistic outpatient setting. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Di+Lorenzo%2C+Rosaria%22">Di Lorenzo, Rosaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cameli%2C+Michela%22">Cameli, Michela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piemonte%2C+Chiara%22">Piemonte, Chiara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bolondi%2C+Marisa%22">Bolondi, Marisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Landi%2C+Giulia%22">Landi, Giulia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pollutri%2C+Gabriella%22">Pollutri, Gabriella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spattini%2C+Ludovica%22">Spattini, Ludovica</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moretti%2C+Valentina%22">Moretti, Valentina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferri%2C+Paola%22">Ferri, Paola</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nordic+Journal+of+Psychiatry%22">Nordic Journal of Psychiatry</searchLink>. 2018, Vol. 72 Issue 3, p214-220. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22People+with+schizophrenia%22">People with schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Psychotherapy%22">Psychotherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+services%22">Mental health services</searchLink><br /><searchLink fieldCode="DE" term="%22Outpatient+medical+care%22">Outpatient medical care</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To evaluate paliperidone palmitate 1-month formulation (PP1M) effectiveness in a naturalistic outpatient psychiatric setting. Materials and methods: We collected data from 50 outpatients affected by schizophrenia disorders treated with PP1M for 12 months in an Italian Mental Health Department. After analyzing selected demographic, clinical and pharmacological variables, we performed mirror analysis to compare psychiatric hospitalizations and urgent consultations required by the same patient 6 and 12 months before and after PP1M implementation (primary outcome). We analyzed clinical improvement in symptom (Clinical Global Impression-severity and improvement) and functioning (Global Assessment of Functioning) scales and drop-out rate during the 12-month PP1M treatment (secondary outcome). Data were statistically analyzed. Results: The mean PP1M dose was 93.5mg (±27.7 SD) with a mean interval between each injection of 27.1 d (±4.5 SD). Twenty-three patients (46%) reported adverse effects (sexual dysfunctions, weight gain and extrapyramidal symptoms).Fifteen patients (30%) dropped out after 137.2 d (±103.1 SD) on average: six due to the lack of therapeutic adherence, six due to inefficacy and three due to adverse events. The drop-out patients presented more severe clinical profile in CGI-S and GAF scores at T0 in comparison with others. At mirror analysis, 12-month but not 6-month PP1M treatment statistically significantly reduced psychiatric hospitalizations (t=2.3, p<.05) and urgent consultations (t=2.1, p<.05). Both scale scores showed statistically significant improvement at T12 in comparison to T0. Conclusions: This naturalistic study indicates that long-term PP1M treatment was safe and effective in preventing hospitalizations and urgent consultations as well as in improving clinical course. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nordic Journal of Psychiatry is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=128084911 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/08039488.2017.1420819 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 214 Subjects: – SubjectFull: People with schizophrenia Type: general – SubjectFull: Psychotherapy Type: general – SubjectFull: Pathological psychology Type: general – SubjectFull: Mental health services Type: general – SubjectFull: Outpatient medical care Type: general Titles: – TitleFull: Clinical improvement, relapse and treatment adherence with paliperidone palmitate 1-month formulation: 1-year treatment in a naturalistic outpatient setting. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Di Lorenzo, Rosaria – PersonEntity: Name: NameFull: Cameli, Michela – PersonEntity: Name: NameFull: Piemonte, Chiara – PersonEntity: Name: NameFull: Bolondi, Marisa – PersonEntity: Name: NameFull: Landi, Giulia – PersonEntity: Name: NameFull: Pollutri, Gabriella – PersonEntity: Name: NameFull: Spattini, Ludovica – PersonEntity: Name: NameFull: Moretti, Valentina – PersonEntity: Name: NameFull: Ferri, Paola IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2018 Type: published Y: 2018 Identifiers: – Type: issn-print Value: 08039488 Numbering: – Type: volume Value: 72 – Type: issue Value: 3 Titles: – TitleFull: Nordic Journal of Psychiatry Type: main |
| ResultId | 1 |
