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Serum neurofilament light chain in patients with acute cerebrovascular events.

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Title: Serum neurofilament light chain in patients with acute cerebrovascular events.
Authors: De Marchis, G. M., Katan, M., Barro, C., Fladt, J., Traenka, C., Seiffge, D. J., Hert, L., Gensicke, H., Disanto, G., Sutter, R., Peters, N., Sarikaya, H., Goeggel‐Simonetti, B., El‐Koussy, M., Engelter, S., Lyrer, P. A., Christ‐Crain, M., Arnold, M., Kuhle, J., Bonati, L. H.
Source: European Journal of Neurology. Mar2018, Vol. 25 Issue 3, p562-568. 7p. 2 Charts, 2 Graphs.
Subjects: Serum, Cytoplasmic filaments, Cerebrovascular disease patients, Stroke prognosis, Diffusion tensor imaging
Abstract: Background and purpose: Serum neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) and transient ischemic attack (TIA). Methods: Nested within a prospective cohort study, we compared levels of serum neurofilament light chain (sNfL) drawn within 24 h from symptom onset in patients with AIS or TIA. Patients without magnetic resonance imaging on admission were excluded. We assessed whether sNfL was associated with: (i) clinical severity on admission, (ii) diagnosis of AIS vs. TIA, (iii) infarct size on admission magnetic resonance diffusion‐weighted imaging (MR‐DWI) and (iv) functional outcome at 3 months. Results: We analyzed 504 patients with AIS and 111 patients with TIA. On admission, higher National Institutes of Health Stroke Scale (NIHSS) scores were associated with higher sNfL: NIHSS score < 7, 13.1 pg/mL [interquartile range (IQR), 5.3–27.8]; NIHSS score 7–15, 16.7 pg/mL (IQR, 7.4–34.9); and NIHSS score > 15, 21.0 pg/mL (IQR, 9.3–40.4) (P = 0.01). Compared with AIS, patients with TIA had lower sNfL levels [9.0 pg/mL (95% confidence interval, 4.0–19.0) vs. 16.0 pg/mL (95% confidence interval, 7.3–34.4), P < 0.001], also after adjusting for age and NIHSS score (P = 0.006). Among patients with AIS, infarct size on admission MR‐DWI was not associated with sNfL, either in univariate analysis (P = 0.15) or after adjusting for age and NIHSS score on admission (P = 0.56). Functional outcome 3 months after stroke was not associated with sNfL after adjusting for established predictors. Conclusions: In conclusion, among patients admitted within 24 h of AIS or TIA onset, admission sNfL levels were associated with clinical severity on admission and TIA diagnosis, but not with infarct size on MR‐DWI acquired on admission or functional outcome at 3 months. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Serum neurofilament light chain in patients with acute cerebrovascular events.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22De+Marchis%2C+G%2E+M%2E%22&quot;&gt;De Marchis, G. M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Katan%2C+M%2E%22&quot;&gt;Katan, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Barro%2C+C%2E%22&quot;&gt;Barro, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fladt%2C+J%2E%22&quot;&gt;Fladt, J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Traenka%2C+C%2E%22&quot;&gt;Traenka, C.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Seiffge%2C+D%2E+J%2E%22&quot;&gt;Seiffge, D. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hert%2C+L%2E%22&quot;&gt;Hert, L.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gensicke%2C+H%2E%22&quot;&gt;Gensicke, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Disanto%2C+G%2E%22&quot;&gt;Disanto, G.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sutter%2C+R%2E%22&quot;&gt;Sutter, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Peters%2C+N%2E%22&quot;&gt;Peters, N.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sarikaya%2C+H%2E%22&quot;&gt;Sarikaya, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Goeggel‐Simonetti%2C+B%2E%22&quot;&gt;Goeggel‐Simonetti, B.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22El‐Koussy%2C+M%2E%22&quot;&gt;El‐Koussy, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Engelter%2C+S%2E%22&quot;&gt;Engelter, S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lyrer%2C+P%2E+A%2E%22&quot;&gt;Lyrer, P. A.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Christ‐Crain%2C+M%2E%22&quot;&gt;Christ‐Crain, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Arnold%2C+M%2E%22&quot;&gt;Arnold, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kuhle%2C+J%2E%22&quot;&gt;Kuhle, J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Bonati%2C+L%2E+H%2E%22&quot;&gt;Bonati, L. H.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Mar2018, Vol. 25 Issue 3, p562-568. 7p. 2 Charts, 2 Graphs.
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  Data: Background and purpose: Serum neurofilaments are markers of axonal injury. We addressed their diagnostic and prognostic role in acute ischemic stroke (AIS) and transient ischemic attack (TIA). Methods: Nested within a prospective cohort study, we compared levels of serum neurofilament light chain (sNfL) drawn within 24 h from symptom onset in patients with AIS or TIA. Patients without magnetic resonance imaging on admission were excluded. We assessed whether sNfL was associated with: (i) clinical severity on admission, (ii) diagnosis of AIS vs. TIA, (iii) infarct size on admission magnetic resonance diffusion‐weighted imaging (MR‐DWI) and (iv) functional outcome at 3 months. Results: We analyzed 504 patients with AIS and 111 patients with TIA. On admission, higher National Institutes of Health Stroke Scale (NIHSS) scores were associated with higher sNfL: NIHSS score &lt; 7, 13.1 pg/mL [interquartile range (IQR), 5.3–27.8]; NIHSS score 7–15, 16.7 pg/mL (IQR, 7.4–34.9); and NIHSS score &gt; 15, 21.0 pg/mL (IQR, 9.3–40.4) (&lt;italic&gt;P&lt;/italic&gt; = 0.01). Compared with AIS, patients with TIA had lower sNfL levels [9.0 pg/mL (95% confidence interval, 4.0–19.0) vs. 16.0 pg/mL (95% confidence interval, 7.3–34.4), &lt;italic&gt;P&lt;/italic&gt; &lt; 0.001], also after adjusting for age and NIHSS score (&lt;italic&gt;P&lt;/italic&gt; = 0.006). Among patients with AIS, infarct size on admission MR‐DWI was not associated with sNfL, either in univariate analysis (&lt;italic&gt;P&lt;/italic&gt; = 0.15) or after adjusting for age and NIHSS score on admission (&lt;italic&gt;P&lt;/italic&gt; = 0.56). Functional outcome 3 months after stroke was not associated with sNfL after adjusting for established predictors. Conclusions: In conclusion, among patients admitted within 24 h of AIS or TIA onset, admission sNfL levels were associated with clinical severity on admission and TIA diagnosis, but not with infarct size on MR‐DWI acquired on admission or functional outcome at 3 months. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=128132736
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