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Learning and memory performance following acute intranasal insulin administration in abstinent smokers.

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Title: Learning and memory performance following acute intranasal insulin administration in abstinent smokers.
Authors: Hamidovic, Ajna, Candelaria, Lionel, Rodriguez, Ihsan, Yamada, Mikiko, Nawarskas, James, Burge, Mark R.
Source: Human Psychopharmacology: Clinical & Experimental. Mar2018, Vol. 33 Issue 2, p1-1. 7p.
Subjects: Physiological effects of insulin, Memory, Learning, Smoking cessation, Cigarette smokers, Nicotine, Intranasal administration
Abstract: Abstract: The highest incidence of relapse to smoking occurs within the first 2 weeks of a cessation attempt. In addition to enhanced nicotine craving, this phase of smoking cessation is also marked by learning and memory dysfunction. Many smokers are not able to overcome these symptoms, and they relapse to smoking shortly after trying to quit. In two clinical studies, we evaluated intranasal insulin for efficacy in improving learning and memory function during nicotine withdrawal. Our first study was a crossover evaluation (N = 19) following 20 hr of smoking abstinence. Study 2 was a parallel design study (N = 50) following 16 hr of abstinence. Intranasal insulin (60 IU) dose was administered in both studies and cognitive function was measured using California Verbal Learning Test‐II. Intranasal insulin did not improve learning over the 5 verbal learning trials. In addition, intranasal insulin did not improve either short‐ or long‐delay recall in either study. In summary, the one‐time administration of intranasal insulin does not improve verbal learning and memory in smokers. Whether longer administration schedules may be of benefit should be evaluated in future studies. [ABSTRACT FROM AUTHOR]
Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Learning and memory performance following acute intranasal insulin administration in abstinent smokers.
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  Data: <searchLink fieldCode="AR" term="%22Hamidovic%2C+Ajna%22">Hamidovic, Ajna</searchLink><br /><searchLink fieldCode="AR" term="%22Candelaria%2C+Lionel%22">Candelaria, Lionel</searchLink><br /><searchLink fieldCode="AR" term="%22Rodriguez%2C+Ihsan%22">Rodriguez, Ihsan</searchLink><br /><searchLink fieldCode="AR" term="%22Yamada%2C+Mikiko%22">Yamada, Mikiko</searchLink><br /><searchLink fieldCode="AR" term="%22Nawarskas%2C+James%22">Nawarskas, James</searchLink><br /><searchLink fieldCode="AR" term="%22Burge%2C+Mark+R%2E%22">Burge, Mark R.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Mar2018, Vol. 33 Issue 2, p1-1. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Physiological+effects+of+insulin%22">Physiological effects of insulin</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Learning%22">Learning</searchLink><br /><searchLink fieldCode="DE" term="%22Smoking+cessation%22">Smoking cessation</searchLink><br /><searchLink fieldCode="DE" term="%22Cigarette+smokers%22">Cigarette smokers</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotine%22">Nicotine</searchLink><br /><searchLink fieldCode="DE" term="%22Intranasal+administration%22">Intranasal administration</searchLink>
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  Label: Abstract
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  Data: Abstract: The highest incidence of relapse to smoking occurs within the first 2 weeks of a cessation attempt. In addition to enhanced nicotine craving, this phase of smoking cessation is also marked by learning and memory dysfunction. Many smokers are not able to overcome these symptoms, and they relapse to smoking shortly after trying to quit. In two clinical studies, we evaluated intranasal insulin for efficacy in improving learning and memory function during nicotine withdrawal. Our first study was a crossover evaluation (N = 19) following 20 hr of smoking abstinence. Study 2 was a parallel design study (N = 50) following 16 hr of abstinence. Intranasal insulin (60 IU) dose was administered in both studies and cognitive function was measured using California Verbal Learning Test‐II. Intranasal insulin did not improve learning over the 5 verbal learning trials. In addition, intranasal insulin did not improve either short‐ or long‐delay recall in either study. In summary, the one‐time administration of intranasal insulin does not improve verbal learning and memory in smokers. Whether longer administration schedules may be of benefit should be evaluated in future studies. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/hup.2649
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      – Code: eng
        Text: English
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      – SubjectFull: Physiological effects of insulin
        Type: general
      – SubjectFull: Memory
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      – SubjectFull: Nicotine
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      – SubjectFull: Intranasal administration
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              Text: Mar2018
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